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Full-Text Articles in Physical Sciences and Mathematics
Chemoenzymatic Synthesis Of An Analogue Of The Potent Antifungal Mycosubtilin, Mayank Srivastava
Chemoenzymatic Synthesis Of An Analogue Of The Potent Antifungal Mycosubtilin, Mayank Srivastava
Master's Theses and Doctoral Dissertations
Mycosubtilin is a naturally occurring antifungal obtained from Bacillus subtilis that also displays limited antibiotic activity. Structurally, mycosubtilin is a macrocycliclipoheptapeptide of sequence Asn-Tyr-Asn-Gln-Pro-Ser-Asn, with the N-terminal Asn joined by a β-amino fatty acid. Besides the antifungal and antibiotic activities,these molecules are also hemolytic in nature. Hence, the purpose of this study is to synthesize a potent antifungal analogue of mycosubtilin, with a modified β-amino fatty acid, devoid of any hemolytic activity. A chemoenzymatic approach was used to synthesize the cyclic peptide, which involved the synthesis of the linear peptide chain of desired amino acid sequence, thiophenylderivatization of the peptide …
Synthesis And Purification Of Potential Antimicrobial Peptides, Christopher Ryan Snyder
Synthesis And Purification Of Potential Antimicrobial Peptides, Christopher Ryan Snyder
Master's Theses and Doctoral Dissertations
No abstract provided.