Physical Sciences and Mathematics Commons^™

Determination Of Thiamine In Solution By Uv-Visible Spectrophotometry: The Effect Of Interactions With Gold Nanoparticles, Michael Vincent Zielinski

Master's Theses and Doctoral Dissertations

The method presented here provides the foundation for a simple and selective qualitative determination of thiamine in solution. Gold nanoparticles in the presence of thiamine results in the formation of a secondary peak in the absorbance spectrum of the mixture. This peak can be used as an indicator of thiamine, which is useful for the qualitative analysis of solutions, and may provide an alternative to other methods for evaluating thiamine in blood and other biological systems. This method uses gold nanoparticles of a size around 20 to 30 nm and involves their selective interaction with thiamine, compared to selected amino …

Design, Synthesis And Evaluation Of Small Molecules As Inhibitors Of Plasminogen Activator Inhibitor-1, Darshani Avanthi Weerakoon

Master's Theses and Doctoral Dissertations

Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. Excessive levels of PAI-1 inhibit urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), which regulates fibrinolysis as well as the development of different pathological diseases like obesity, metabolic syndrome, tumor invasion and metastasis, and coronary heart disease. Currently, there is no Food and Drug Administration approval for inactivating higher levels of PAI-1. Therefore, PAI-1 is considered an attractive drug target. Due to PAI-1’s different structural conformations and multiple binding domains, development of PAI-1 inhibitors is a challenging situation. In this research study, we describe …

Technological, Organizational, And Environmental Factors Affecting The Adoption Of Cloud Enterprise Resource Planning (Erp) Systems, John Njenga Kinuthia

Master's Theses and Doctoral Dissertations

The purpose of this study was to determine the differences between organizations that adopted Cloud Enterprise Resource Planning (Cloud ERP) systems and organizations that did not adopt Cloud ERP systems based on the Technological, Organizational, and Environmental (TOE) factors. Relevant technological factors were identified as relative advantage of Cloud ERP systems, compatibility of Cloud ERP systems, and security concern of Cloud ERP system environment. Organizational factors included top management support, organizational readiness, size of the organization, centralization, and formalization. External environment factors were identified as competitive pressure and vendor support.

A survey was developed using constructs from existing studies of …

Design, Synthesis, And Biological Evaluation Of Non-Symmetric Smal, Himabindu Anumala

Master's Theses and Doctoral Dissertations

Plasminogen activator inhibitor-1 (PAI-1) is a member of the serpin family of proteins, a primary inhibitor of both tissue-type and urokinase-type plasminogen activators in plasma, and is a well-established risk factor in various disease conditions. Increased levels of active PAI-1 in plasma are correlated with the development of atherosclerosis, diabetes, stroke, and other maladies. In the present study, we describe the synthesis of two new series of compounds that aim to reduce physiologically active PAI-1 levels. These molecules are related to a series of bis-arylsulfonimides and arylsulfonamides connected by short linking diamines, and to a series of hydrazine-based analogues. These …

Advancements In The Diastereoselective Synthesis Of Acyl Pyrrolidines Via The Tandem Aza-Cope—Mannich Cyclization Pathway, Danielle St. Germaine

Master's Theses and Doctoral Dissertations

We have developed a Lewis-acid catalyzed, diastereoselective aza-Cope rearrangement— Mannich cyclization to form acyl pyrrolidines from conformationally mobile substrates. In earlier studies from our lab, Brønsted acid-catalyzed reactions to form the same acyl pyrrolidines resulted in diastereoselectivities of 8:1 trans to cis at elevated temperatures (60 °C) over the course of 150 minutes. We have demonstrated an improvement in our method yielding exclusively the trans isomers at ambient temperature with substoichiometric amounts of BF₃•OEt₂ within 3 minutes. Catalyst loadings as low as 0.05 equivalents of BF₃•OEt₂ initiate this transformation. Our synthetic method employs the …

Modeling Of An Upper Midwest Forest Boundary Layer And Vehicle Indoor Air Quality, Phillip Stratton

Master's Theses and Doctoral Dissertations

The key to understanding tropospheric chemistry begins with the hydroxyl and hydroperoxy radicals. Recent research suggests that there is still considerable uncertainty in our understanding of the sources of these radicals and their role as sinks. The work detailed in this thesis describes a computational approach to modeling the hydroxyl and hydroperoxy radicals in a forest environment and attempts to shed further light on the radical budget in a typical Northern Hardwood forest. Additionally, research was conducted with United States Council for Automotive Research in collaboration with Ford, General Motors, and Chrysler to develop a global standard for vehicle indoor …

Mobile Device Vulnerabilities & Securities, Luke Rondeau

Senior Honors Theses and Projects

An investigation on current mobile vulnerabilities and research into security. Also, a proof of concept to show the ease of injecting an Android phone with a virus.

An Investigation Of The User Satisfaction Of Customer Relationship Management Program, Sangeun Lee

Senior Honors Theses and Projects

The thesis investigates user satisfaction for Microsoft Dynamics CRM 2011 by conduction surveys to graduate level students. The training manual was developed to guide the way to follow instructions to create an order and an invoice.

From Climate Action To Coalition: Ypsilanti And Emu As Models For Sustainability, Erica Mooney

Senior Honors Theses and Projects

Inspired by leading EMU's engagement with Ypsilanti's climate Action Plan in 2011, a journey began to discovering ways to cultivate healthy relationships through sustainability. How have other universities addressed climate change? How have other municipalities work with schools addressing sustainability? I explored national programs as well as a thorough review of Michigan's other public universitites. This thesis is a mix of best practices research and a proposal to both city and school administrators and stakeholders. Reviewing what other campuses and towns have done to address environmental and social justice, and the complex realms of economic and community development, a coalition …