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Articles 1 - 12 of 12
Full-Text Articles in Physical Sciences and Mathematics
A Novel Defense Mechanism Against Web Crawler Intrusion, Alireza Aghamohammadi
A Novel Defense Mechanism Against Web Crawler Intrusion, Alireza Aghamohammadi
Master's Theses and Doctoral Dissertations
Web robots also known as crawlers or spiders are used by search engines, hackers and spammers to gather information about web pages. Timely detection and prevention of unwanted crawlers increases privacy and security of websites. In this research, a novel method to identify web crawlers is proposed to prevent unwanted crawler to access websites. The proposed method suggests a five-factor identification process to detect unwanted crawlers. This study provides the pretest and posttest results along with a systematic evaluation of web pages with the proposed identification technique versus web pages without the proposed identification process. An experiment was performed with …
Synthesis Of Environmentally-Friendly Polyurethane Dispersions Based On Soybean Oil- Derived Polyols And Their Applications In Advanced Water-Based And Uv-Cure Coatings, Senthikumar Rengasamy
Synthesis Of Environmentally-Friendly Polyurethane Dispersions Based On Soybean Oil- Derived Polyols And Their Applications In Advanced Water-Based And Uv-Cure Coatings, Senthikumar Rengasamy
Master's Theses and Doctoral Dissertations
Polyurethane dispersions (PUD) have established themselves as most versatile polymeric binder in coating, adhesive, sealant, and elastomer industries. Like any other polymers, PUDs also have certain limitations, such as hydrolytic stability, water resistance, and oil resistance. In order to develop these properties, two different polyol families were synthesized. The first polyol can be used in ambient curable systems, and the second can be utilized in ultraviolet radiation cure coatings. For ambient curable systems polyether chemistry based soy-polyol was developed from epoxidized soy fatty acid methyl ester (ESFAME). The cationic ring opening of oxirane oxygen groups from ESFAME resulted in polyol …
Chemoenzymatic Synthesis Of An Analogue Of The Potent Antifungal Mycosubtilin, Mayank Srivastava
Chemoenzymatic Synthesis Of An Analogue Of The Potent Antifungal Mycosubtilin, Mayank Srivastava
Master's Theses and Doctoral Dissertations
Mycosubtilin is a naturally occurring antifungal obtained from Bacillus subtilis that also displays limited antibiotic activity. Structurally, mycosubtilin is a macrocycliclipoheptapeptide of sequence Asn-Tyr-Asn-Gln-Pro-Ser-Asn, with the N-terminal Asn joined by a β-amino fatty acid. Besides the antifungal and antibiotic activities,these molecules are also hemolytic in nature. Hence, the purpose of this study is to synthesize a potent antifungal analogue of mycosubtilin, with a modified β-amino fatty acid, devoid of any hemolytic activity. A chemoenzymatic approach was used to synthesize the cyclic peptide, which involved the synthesis of the linear peptide chain of desired amino acid sequence, thiophenylderivatization of the peptide …
Characterization Of Short Chain Fatty Acids In Microbial Cultures By Dart-Ms And Gc-Ms, Shilpa Boppana
Characterization Of Short Chain Fatty Acids In Microbial Cultures By Dart-Ms And Gc-Ms, Shilpa Boppana
Master's Theses and Doctoral Dissertations
Colonic bacterial degradation of starch and other carbon sources produces short-chain fatty acids (SCFA) such as butyrate and lactate, which are important in human health and disease. Analysis of the results of mono- and co-cultures in in vitro systems has led to the conclusion that diverse microbial organisms may each contribute in part to the complete metabolism to produce SCFA. GC- MS and DART- MS were investigated as analytical tools in the present study to evaluate the production of butyrate and lactate in a test tube and bioreactor mono- and co-cultures. The overall research goal is to investigate biological model …
Use Of Support Vector Machines And Fabry-Perot Interferometry To Classify States Of A Laser, John Motley Mckinnon
Use Of Support Vector Machines And Fabry-Perot Interferometry To Classify States Of A Laser, John Motley Mckinnon
Master's Theses and Doctoral Dissertations
This thesis develops an algorithm that can determine if a laser is functioning correctly over a long period of time. A Fourier fit is created to model fringe profiles from a Fabry-Perot interferometer, and singular value decomposition is used to reduce noise in each signal. Levenberg-Marquardt gradient descent is performed to correctly locate the center of each image and to optimize each fit with respect to the spatial frequency. The Fourier fit is used to extract important information from each image to be used for separating the image types from one another. Principal component analysis is used to reduce the …
Arachidonate Oxidation Metabolite Profiles For Myoglobin And A Structurally Altered Form Of Myoglobin Produced In Muscle Disease Or Trauma, Kathryn Rae Lawrence
Arachidonate Oxidation Metabolite Profiles For Myoglobin And A Structurally Altered Form Of Myoglobin Produced In Muscle Disease Or Trauma, Kathryn Rae Lawrence
Master's Theses and Doctoral Dissertations
Myoglobin (Mb) and Myoglobin-H (Mb-H) react with glycerophosphocholine (GPC) lipid in the presence of oxygen. This reaction allows the heme group in the protein the chance to induce peroxidation reactions with the lipid. Several aldehyde products of this type of reaction with arachadonic acid have previously been determined, with Mb generating greater quantities of aldehyde products than Mb-H. The focus of this research was to establish the presence of some products from the reactions of Mb and Mb-H with GPC (which contains arachadonic acid) that are more prevalent from Mb-H than Mb, or that only form from the reaction of …
Protein-Protein Interaction Between Multi-Functional Protein Cad And Protein Phosphastase 1 (Pp1), Meenal Mhaskar
Protein-Protein Interaction Between Multi-Functional Protein Cad And Protein Phosphastase 1 (Pp1), Meenal Mhaskar
Master's Theses and Doctoral Dissertations
Uncontrolled cell proliferation, a hallmark of cancer, is associated with activation of CAD, a multifunctional protein that catalyzes the first three steps in pyrimidine biosynthesis. The cell cycle dependent regulation of pyrimidine biosynthesis is a consequence of sequential phosphorylation of CAD Thr-456 and Ser-1406 by the MAP kinase and PKA cascades, respectively. The mechanism that controls the timing of these events is not well understood. Our hypothesis is that timing of the activation and nucleocytoplasmic dynamics of CAD is controlled by signaling complexes with kinases and phosphatases. Interestingly, a consensus sequence for PP1 targeting proteins is located immediately adjacent to …
Exploration Of Non-Specific Peptide Inhibitors Of Amylin Aggregation In Type-2 Diabetes, Hector Figueroa
Exploration Of Non-Specific Peptide Inhibitors Of Amylin Aggregation In Type-2 Diabetes, Hector Figueroa
Senior Honors Theses and Projects - Chemistry
Polypeptide aggregation is seen in a variety of diseases (termed amyloidoses) but remains poorly understood. This study uses the polypeptide amylin to investigate how nonspecific interactions between peptides can inhibit aggregation. A set of 5 heptapeptides was assessed for its ability to impact amylin-induced membrane damage and aggregation. Solvent effects precluded accurate assessment of the impact on membrane damage; however a method of subtracting out the solvent effect is offered. The two most hydrophobic compounds showed the ability to substantially slow amylin aggregation, while those compounds carrying charged side chains tended to increase the rate of aggregation. Only one compound …
Short Chain Fatty Acid Production By Probiotic Organisms In The Gastrointestinal Tract, Elyssa Rautiola
Short Chain Fatty Acid Production By Probiotic Organisms In The Gastrointestinal Tract, Elyssa Rautiola
Senior Honors Theses and Projects
Interest in determining the mechanism by which pro biotic bacteria in the gastrointestinal tract produce short chain fatty acids (SCFA) has increased over the past few years. This study uses gas chromatography and mass spectrometry to characterize lactate production in aerobic test tube cultures, aerobic bioreactor cultures, and anaerobic bioreactor cultures. To collect anaerobic bioreactor samples, a novel in vitro anaerobic model was developed. The pH and colony forming units of each bacterial sample was also measured in order to understand the correlation between lactate production and bacterial growth. The purpose of this study was to analyze production of SCFA …
Synthesis Of 1-Pyrenyldiazomethane For Derivatization Of Short-Chain Fatty Acids, Mary E. Kalvaitis
Synthesis Of 1-Pyrenyldiazomethane For Derivatization Of Short-Chain Fatty Acids, Mary E. Kalvaitis
Senior Honors Theses and Projects
Use of I-pyrenyldiazomethane (PDAM) for derivatizing short-chain fatty acids (SCFA) is a successful way to analyze complex SCF A samples quickly and with minimal sample preparation. The costs associated with ordering PDAM from a commercial source can be high, typically more than $300 not including shipping costs. This project developed a simple two-step synthesis procedure that can be used in undergraduate chemistry laboratories. We found that the PDAM produced by this procedure is pure enough to use for our derivatization needs without further purification. This synthesis can be used to further explore the use of PDAM for fast and simple …
Study Of The Reaction Of Nitriles With Dialkyl Phosphites For Synthesis Of A-Amino-Bis-Phosphonates, Prasanna Vanja
Study Of The Reaction Of Nitriles With Dialkyl Phosphites For Synthesis Of A-Amino-Bis-Phosphonates, Prasanna Vanja
Master's Theses and Doctoral Dissertations
Amino bisphosphonate compounds are found in a vast array of products from water chelators to flame retardants to pharmaceuticals. Previous methods to synthesize these compounds involved the use of protic acids, which don’t provide ideal conditions for the starting materials containing acid labile functional groups in pharmaceutical compounds. The present study adopts a new synthetic route in which diethyl phosphite addition to the nitrile would be effected in the presence of a Lewis acid catalyst. This study utilized lanthanum trifluoromethane sulfonate as the Lewis acid catalyst, facilitating the addition of the P-H bond across the nitrile triple bond. Product purification …
The Tilt Of The Boron Triangle In Tourmaline, Charles J. Badgerow
The Tilt Of The Boron Triangle In Tourmaline, Charles J. Badgerow
Senior Honors Theses and Projects
The tourmaline mineral group has a highly complex chemical composition and provides a wealth of information on Earth's processes. Past research has revealed numerous mysteries regarding the structure of the boron triangle within tourmaline, especially as it bonds to the Z- and Z'- cation sites. Although the Z- and Z' - are nominally the same site, the Z'-site has a greater effect on the stereochemistry of the boron triangle. Further, the Z' -site has a shorter bond-length with the boron triangle than the Z-site. We hypothesize that this variation affects the stereochemistry of the boron triangle, and have analyzed a …