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Articles 1 - 8 of 8
Full-Text Articles in Physical Sciences and Mathematics
Determination Of The Wavelength Dependence On The Metal Catalyzed Degradation Of The Herbicide Atrazine, Timothy Bertram
Determination Of The Wavelength Dependence On The Metal Catalyzed Degradation Of The Herbicide Atrazine, Timothy Bertram
Honors Theses
Since the advent of modern herbicide use in the early twentieth century, researchers have been plagued with the obvious problem of herbicide disposal. Most herbicides are specifically designed to resist natural degradation processes so that they can remain effective in the field for a substantial amount of time. In addition, they are also made water soluble so that they can be easily applied to crops. Finally, they are specifically produced to kill undesirable plant species in the quickest and often crudest fashions. Due to these specific properties herbicides pose a general threat to other organisms living in the same geographic …
Designing A Remote Navigation System, Jared P. Lazzaro
Designing A Remote Navigation System, Jared P. Lazzaro
Senior Scholar Papers
This project involves the design and implementation of a global electronic tracking system intended for use by trans-oceanic vessels, using the technology of the U.S. Government's Global Positioning System (GPS) and a wireless connection to a networked computer.
Traditional navigation skills are being replaced with highly accurate electronics. GPS receivers, computers, and mobile communication are becoming common among both recreational and commercial boaters. With computers and advanced communication available throughout the maritime world, information can be shared instantaneously around the globe. This ability to monitor one's whereabouts from afar can provide an increased level of safety and efficiency.
Current navigation …
Cisplatin Interstrand Cross-Linking Of Defined Sequence Nucleosomal Dna, Erin Elizabeth Wilkes
Cisplatin Interstrand Cross-Linking Of Defined Sequence Nucleosomal Dna, Erin Elizabeth Wilkes
Honors Theses
DNA interstrand cross-linking agents have been recognized for many years to be powerful antitumor chemotherapeutics. While the interactions between free DNA and many anticancer drugs have been explored extensively, there is less infonnation available about these interactions with nucleosomal DNA. Nitrogen mustards have been reported to exhibit relatively similar cross-linking sites and efficiencies of binding in free and nucleosomal DNA, but mitomycin C exhibits markedly reduced cross-linking near the center of nucleosomal DNA. This current study focuses on cisplatin interstrand cross-linking of the 154 base pair 55 rRNA gene fragment of Xenopus borealis reconstituted with histones from chicken erythrocytes. The …
A Computational Approach To Determining Stability Constants For Transition Metal Ion Complexes, Jason St. Clair
A Computational Approach To Determining Stability Constants For Transition Metal Ion Complexes, Jason St. Clair
Honors Theses
The complexation of metal ions in natural waters plays a critical role in defining the metal's biogeochemistry, Numerous investigators have used various experimental techniques to measure complexation constants in the laboratory, but many constants are still poorly undefined or have yet to be investigated due to the difficulty of some of the experiments. A computational approach to obtaining these constants for complexes of Fe(lII), Fe(D), Cr(lli), Cu(lI), Zn(II), and Cd(II) was explored with varying degrees of success. Calculated Gibbs Free Energies were compared to experimental stability constants. Calculations were performed using Spartan's DFT package at the pEP level and with …
Land Use Patterns In Relation To Lake Water Quality In The Lake Wesserunsett Watershed, Problems In Environmental Science Course (Biology 493), Colby College, Colby Environmental Assessment Team, Colby College
Land Use Patterns In Relation To Lake Water Quality In The Lake Wesserunsett Watershed, Problems In Environmental Science Course (Biology 493), Colby College, Colby Environmental Assessment Team, Colby College
Colby College Watershed Study: Other Area Studies
The Colby Environmental Assessment Team (CEAT) engaged in an extensive data collection and analysis effort from September to December of 2000 to produce a comprehensive evaluation of the ecological health of the Lake Wesserunsett ecosystem. CEAT examined several factors related to lake water quality, including land use within the watershed, the impacts of residential and commercial development, and physical and chemical measurements of the lake itself. Lake water quality was the primary focus of the study due to its predictive value regarding overall watershed function and viability. The accumulation of nutrients in a lake due to surface runoff and erosion …
Interactions Of Ti(Iv) And Sn(Iv) Organometallic Complexes With Double-Stranded Dna, Katherine Macdonald Davies
Interactions Of Ti(Iv) And Sn(Iv) Organometallic Complexes With Double-Stranded Dna, Katherine Macdonald Davies
Honors Theses
In order to understand further the interactions that exist between specific organometallic complexes and DNA, reactions of double-stranded calf-thymus DNA with bis(cyclopentadienyl)titanium dichloride [Cp₂TiC1₂] (TDC), bis(t-butylcyclopentadienyl)titanium dichloride [(C₄H₉Cp)₂TiC1₂] (r-butyl TDC), bis(i-propylcyclopentadienly)titanium dichloride [(C₃H₆Cp)2TiCl₂ a-propyl mc), bis(pentamethylcyclopentadienyl) titanium dichloride [(Cp"₂TiC1₂ (pentarnethyl TDC), triphenyltin chloride (Ph₃SnCl), diphenylrin dichloride (Ph₂SnC1₂) , and triphenyltin acetate (Ph₃SnOAc) were performed. The goal of this research is to establish how the fundamental structure and composition of these compounds determine the effecti veness of their DNA interactions. Each metal compound was incubated with calf thymus DNA at several metal: DNA ratios and reactions were maintained at 37°C at …
Determination Of Nizatidine-Guest Complexation Constants And Computer Aided Molecular Design, Carolyn J. Mordas
Determination Of Nizatidine-Guest Complexation Constants And Computer Aided Molecular Design, Carolyn J. Mordas
Honors Theses
Nizatidine, N-[2-[[[2-[(dimethylamino)methyl]-4-thiazoly]]methy1]thio]ethyl]-N'- methyl- 2-nitro-I,l, ethenediamine, has been investigated for its potential to act as a host to small molecules through hydrogen bonding and pi-pi interactions. In previous work, pyridoxine (vitamin B6) was hypothesized to have a high guest-host binding constant with nizatidine. This was supported through experimental methods involving one and two dimensional NMR spectroscopy, UV-visible spectroscopy, and high performance liquid chromatography. Computer aided molecular design and three dimensional conformationally flexible database searching led to the discovery of other possible guests, including albuterol, which has exhibited even higher binding constants from HPLC.
A Catechol Approach To Natural Product Synthesis, Michelle E. Weber
A Catechol Approach To Natural Product Synthesis, Michelle E. Weber
Honors Theses
This research has focused on the total synthesis of the iron--chelating natural product 1-(2,3-hydroxyphenyl)-4-methoxy-I-butanone. An extract of the iron-cleficient fungus Gleophyllwn lraebeum, this molecule is thought to bind to Fe3+ in a hexacoordinate system to aid in transport through cell walls in order to help regulate iron levels in such iron-deficient fungi. Since the proposed structure of the molecule is based only on the spectral data of a very small sample, our hope is to synthesize and confirm its structure as the extract of the brown rot fungus. We have developed a relatively short retrosynthesis for our work on this …