Physical Sciences and Mathematics Commons^™

Measuring Activity Of Endothelial Nitric Oxide Synthase And Nanodisc Complex Through Nitrate Production, Christopher Verdi, Ghaith Altawallbeh, Mekki Bayachou

Undergraduate Research Posters 2014

Nitric oxide is an important bioregulator generated in various regions throughout the body by a family of isozymes referred to as Nitric Oxide Synthases (NOS). Within vascular endothelial cells, nitric oxide is generated from oxygen and arginine (amino acid) by endothelial nitric oxide synthases (eNOS). Within this environment nitric oxide plays a critical paracrine role, mainly anithrombotic and anti-atherosclerotic. This is accomplished by vessel dilation and prevention of platelet and leukocyte aggregation and adherence to the vessel wall. The activity of the eNOS enzyme has been studied within solution and is well understood. However, the impact that the lipid bilayer …