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Full-Text Articles in Physical Sciences and Mathematics
Goes-R Supervised Machine Learning, Ronald Adomako
Goes-R Supervised Machine Learning, Ronald Adomako
Dissertations and Theses
The GOES-R series is a product line of four satellite, with two currently on-orbit (GOES-16 “East” and GOES-17 “West”). GOES-17 is susceptible to a Loop-Heat-Pipe (LHP) phenomenon where during Fall and Spring seasons, there are times of day where some of the infrared bands records inaccurate readings from the Advanced Baseline Imager (ABI). This occurs from joint astronomical behavior and position of the GOES-17. This calibration issue occurs when the LHP instrument fails to radiate the heat of the sun out of ABI. Predictive Calibration (pCal) is an algorithm developed by instrument vendors for the National Oceanic Atmospheric Agency (NOAA) …
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Dissertations, Theses, and Capstone Projects
The cost of bringing a drug to market is astounding and the failure rate is intimidating. Drug discovery has been of limited success under the conventional reductionist model of one-drug-one-gene-one-disease paradigm, where a single disease-associated gene is identified and a molecular binder to the specific target is subsequently designed. Under the simplistic paradigm of drug discovery, a drug molecule is assumed to interact only with the intended on-target. However, small molecular drugs often interact with multiple targets, and those off-target interactions are not considered under the conventional paradigm. As a result, drug-induced side effects and adverse reactions are often neglected …