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Full-Text Articles in Physical Sciences and Mathematics
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Dissertations, Theses, and Capstone Projects
The cost of bringing a drug to market is astounding and the failure rate is intimidating. Drug discovery has been of limited success under the conventional reductionist model of one-drug-one-gene-one-disease paradigm, where a single disease-associated gene is identified and a molecular binder to the specific target is subsequently designed. Under the simplistic paradigm of drug discovery, a drug molecule is assumed to interact only with the intended on-target. However, small molecular drugs often interact with multiple targets, and those off-target interactions are not considered under the conventional paradigm. As a result, drug-induced side effects and adverse reactions are often neglected …
Rationality, Parapsychology, And Artificial Intelligence In Military And Intelligence Research By The United States Government In The Cold War, Guy M. Lomeo
Theses and Dissertations
A study analyzing the roles of rationality, parapsychology, and artificial intelligence in military and intelligence research by the United States Government in the Cold War. An examination of the methodology behind the decisions to pursue research in two fields that were initially considered irrational.
Cross-Talk: A Shared Parameter Space For Gesturally Extended Human/Machine Improvisation, William Brent, Adam James Wilson
Cross-Talk: A Shared Parameter Space For Gesturally Extended Human/Machine Improvisation, William Brent, Adam James Wilson
Publications and Research
This paper describes Cross-talk, a piece of music and performance system for two instruments augmented with infrared motion-tracking capability, and an artificial software improviser. Cross-talk was commissioned by the Ammerman Center for Arts and Technology at Connecticut College, for the 13th Biennial Symposium on Arts and Technology. The work is part of an ongoing collaboration focused on developing integrated hardware and software performance systems to extend the timbral and expressive capabilities of traditional musical instruments and to generate musical structure in response to information retrieved from human performers in real-time. Artistic motivations and prior related work are presented here, along …