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Full-Text Articles in Physical Sciences and Mathematics
Solid Phase Amide Synthesis Using Staudinger-Vilarrasa Coupling And Microwave Irradiation, Ryan Patrick Schmidtz
Solid Phase Amide Synthesis Using Staudinger-Vilarrasa Coupling And Microwave Irradiation, Ryan Patrick Schmidtz
Undergraduate Honors Thesis Collection
Amide bond formation is an already well documented area of organic chemistry, and is very useful in its application in medicine and pharmaceuticals. However, current methods have not been investigated with regards to optimization of reaction times, solvents, and energy sources. In addition, current methods also utilize toxic solvents to cleave the peptide from the solid phase resin. In our study, we combine the Staudinger and Vilarrasa coupling reactions with microwave irradiation to develop and optimize the synthesis of amide bonds through the use of a solid support. Instead of attaching the peptide to the solid support, our amide bond …
Investigating Ring Closing Metathesis Product Favorability By Varying The Alkyne Substituent On A Dienyne, Meagan E. Hinze
Investigating Ring Closing Metathesis Product Favorability By Varying The Alkyne Substituent On A Dienyne, Meagan E. Hinze
Undergraduate Honors Thesis Collection
Diene metathesis, which is also known as an olefin metathesis, has been very important for the development of synthetic strategies in organic chemistry since it's inception in the 1950s. The olefin metathesis reaction is when two alkenes exchange the carbons on their double bonds, thus producing two new carbon□arbon double bonds.
Optimization Of A Polydimethylsiloxane Based Passive Sampler Of Common Household Volatile Organic Compounds, Jennifer Lynn Osborne
Optimization Of A Polydimethylsiloxane Based Passive Sampler Of Common Household Volatile Organic Compounds, Jennifer Lynn Osborne
Undergraduate Honors Thesis Collection
Dangerous volatile organic compounds, or VOCs, can accumulate as indoor air pollution within homes causing health problems in the habitants. In order to determine the concentration of VOCs in such areas a field-deployable sampler is necessary. The focus of this work has been to develop an inexpensive, reusable, sensitive fielddeployable passive sampler for monitoring VOCs in indoor air. We have devised a sampler that uses polydimethylsiloxane (PDMS), which is a common inexpensive, nonpolar adsorbent. The sampler is comprised of an aluminum bottle coated with the PDMS. In operation, the coated portion is exposed to the air to be sampled. The …
Liquid Carbon Dioxide Extraction Of Various Food Flavors: Evaluation And Analysis, Deven Lee Shinholt
Liquid Carbon Dioxide Extraction Of Various Food Flavors: Evaluation And Analysis, Deven Lee Shinholt
Undergraduate Honors Thesis Collection
Sub- and supercritical carbon dioxide has been utilized as an extraction solvent for a variety of natural compounds. This requires the use of specialized high-pressure vessels. It was reported recently that common laboratory apparatus (centrifuge tubes) could be utilized in liquid carbon dioxide extractions obviating the need for specialized equipment. Various herbs and spices (including orange, lemon, lime, and grapefruit zest, oregano, rosemary, sage, spearmint, nutmeg, black peppercorns, cloves, caraway seeds, and vanilla beans) were used as substrates for liquid carbon dioxide extractions by this straightforward technique. The extracted oils, containing terpenes and terpenoids, were then analyzed through GC/MS. Liquid …
A Comparison Of The Surface Adsorption Characteristics Of Reduced And Oxidized Cytochrome C On A Fused Silica Surface Via Attenuated Total Internal Reflection Spectroscopy, Casey M. Kraning
Undergraduate Honors Thesis Collection
No abstract provided.
Adsorption Studies Of Cytochrome C On A Silica Nanoparticle Surface, Carrie Ann Hedge
Adsorption Studies Of Cytochrome C On A Silica Nanoparticle Surface, Carrie Ann Hedge
Undergraduate Honors Thesis Collection
This honors thesis investigated the conformational changes in cytochrome c when it is adsorbed to silica nanoparticle surfaces before denaturant as well as when it is exposed to denaturant and then allowed to adsorb to silica nanoparticles.
Synthesis Of Hydroxycyclopentenones Via Titanium Complexes, Joeseph David Frasca
Synthesis Of Hydroxycyclopentenones Via Titanium Complexes, Joeseph David Frasca
Undergraduate Honors Thesis Collection
The electronegativity difference in the titanium-carbon bond has provided a synthetic framework in the formation of a wide range of organic products. Hydroxycyclopentenones are examples of such products and can be synthesized through a titanacyclobutene intermediate via a one-pot procedure. The process involves the incorporation of carbon monoxide into the titanacyclobutene ring with a concomitant addition of an alkyl halide in the presence of samarium diiodide. The synthetic utility of this reaction was explored by varying the alkyl halide. The results of such explorations show a variable tolerance for particular alkyl groups. The details of this project will be discussed.
Nontraditional Synthesis Of Organometallic Compounds And Allylic Alcohols, Andrew J. Hesse
Nontraditional Synthesis Of Organometallic Compounds And Allylic Alcohols, Andrew J. Hesse
Undergraduate Honors Thesis Collection
One of the central dogmas of chemistry is the use of convection heating to increase rate and yields of reactions. However, other methods for the impartation of energy do exist. Microwave irradiation uses high power waves to directly excite molecule into higher energy states. This speeds up the kinetics of the reaction and thermodynamically favorable products are formed at a higher rate. This project successfully uses microwave irradiation to perform organometallic syntheses of iron based compounds such as ferrocene and iron diene tricarbonyls. Another alternative method involves using mechanical energy as a substitute for thermal energy. By rapidly colliding reactants …