Physical Sciences and Mathematics Commons^™

Design And Synthesis Of Tlr2 And Tlr6 Heterodimer Ligands, A Triply Functionalized Α-Galcer Derivative For Identifying Proteins Involved In Glycolipid Trafficking, And The Disaccharide Of Staphylococcus Aureus Cp8 Towards A Self-Adjuvanting Vaccine, Sara Mayeth Mata

Theses and Dissertations

Toll like receptors (TLRs) are found on B cells, macrophages, monocytes, and dendritic cells, and these cells belong to the innate immune system that recognizes antigens and induces multiple cell responses through the release of cytokines. TLR1, TLR2 and TLR6 function as heterodimers, either as TLR1/TLR2 or TLR2/TLR6 to recognize lipopeptides. TLR1/2 dimer activation releases inflammatory cytokines, while TLR2/TLR6 dimer activation releases immunomodulatory cytokines. Based on the size of the binding pocket between TLR2 and TLR6, it was hypothesized that lipopeptides, such as FSL1, could be simplified while keeping overall activity. FSL1 is a lipopeptide first isolated from Mycoplasma salivarum …