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Full-Text Articles in Physical Sciences and Mathematics
Cancerous Male And Female Gene Expression, Clarissa Farmer, E. Shannon Tass
Cancerous Male And Female Gene Expression, Clarissa Farmer, E. Shannon Tass
Journal of Undergraduate Research
Genetic diagnosing is becoming more popular, as well as more and more accurate. However, many genetic diseases have complex genetic effects and are still not fully understood. Transthyretin Amyloidosis (ATTR; also known as familial or hereditary amyloidosis) is a terminal genetic disease. It is caused by unstable transthyretin proteins that fold improperly, and then deteriorate. The fragmented proteins are deposited outside of the cell and build up in the tissues over time, forming insoluble oligomers. The oligomers continue to grow into Amyloid fibrils, which adversely affect many organs in the body, eventually causing their failure. In order to accurately diagnose, …
Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen
Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen
Journal of Undergraduate Research
The resistance of tumor cells to chemotherapy is a critical problem in the clinic and is a common cause of mortality in cancer. Emerging data suggests that resistance to chemotherapy is caused by a tumor-expressed protein called 14-3-3ζ, yet the mechanism to explain 14-3-3ζ-mediated chemoresistance is not completely understood (1). Rapid growing tumors often outgrow their blood supply resulting in regions of hypoxia (low glucose and oxygen). These cells must adapt or die and those that do adapt often become metastatic and chemoresistant. A recently proposed mechanism by which cancer cells are able to adapt to hypoxia is via autophagy, …