Physical Sciences and Mathematics Commons^™

The Synthesis Of Deuterated Arylamine Dna Adducts For Use In The Development Of An Isotope Dilution Lc/Ms/Ms Method, Philip Dmitri Olsen

LSU Doctoral Dissertations

Polycyclic aromatic amines (arylamines) are a class of chemical carcinogens that are prevalent in environmental and industrial settings. In order to study the mechanism of their toxicity a quantitative and qualitative detection method was developed to measure the C8-adenine adducts of benzidine and 2-aminofluorene in DNA samples. To do this a novel synthetic method using a palladium catalyst was developed to prepare authentic and deuterated arylamine adducts to serve as standards. These standards were then used to develop a high performance liquid chromatography, electrospray, tandem mass spectrometry, isotope dilution, detection method. To demonstrate the validity of this method two spike …

Artin-Schreier Families And 2-D Cycle Codes, Cem Guneri

LSU Doctoral Dissertations

We start with the study of certain Artin-Schreier families. Using coding theory techniques, we determine a necessary and sufficient condition for such families to have a nontrivial curve with the maximum possible number of rational points over the finite field in consideration. This result produces several nice corollaries, including the existence of certain maximal curves; i.e., curves meeting the Hasse-Weil bound.We then present a way to represent two-dimensional (2-D) cyclic codes as trace codes starting from a basic zero set of its dual code. This representation enables us to relate the weight of a codeword to the number of rational …

Numerical Simulations Of Dynamical Mass Transfer In Binaries, Patrick Michael Motl

LSU Doctoral Dissertations

We present results from investigations of mass transfer instability in close binary star systems. By unstable mass transfer we mean the exchange of material where the response of the binary to the initial Roche lobe overflow causes the donor to loose even more material. Our work is guided by approximate arguments that dictate the stability boundaries for binary star systems. To proceed further one must explicitly treat extended mass and velocity distributions that are both nitially, and through their subsequent evolution in time, self-consistent. In this dissertation, we present the first three-dimensional, fully self-consistent treatment of mass transfer in close …

Bounding The Wild Set (Counting The Minimum Number Of Wild Primes In Hilbert Symbol Equivalent Number Fields), Marius M. Somodi

LSU Doctoral Dissertations

This dissertation makes a contribution to the study of Witt rings of quadratic forms over number fields. To every pair of algebraic number fields with isomorphic Witt rings one can associate a number, called the minimum number of wild primes. The situation is particularly nice when this number is 0; often it is not 0. Earlier investigations have established lower bounds for this number. In this dissertation an analysis is presented that expresses the minimum number of wild primes in terms of the number of wild dyadic primes. This formula not only gives immediate upper bounds, but can be considered …

Analysis Of Inorganic Materials Using Advanced Nmr And Nqr Techniques, Anthony Adrian Mrse

LSU Doctoral Dissertations

Several advanced solid-state nuclear magnetic resonance (NMR) and nuclear quadrupole resonance (NQR) techniques have been applied to inorganic materials of commercial interest. The specific techniques applied to each system were chosen to solve specific obstacles which impeded the flow of industrial science.

First, the dispersion of brominated flame retardants in polymers is monitored using pulsed ⁸¹Br NQR (nuclear quadrupole resonance) techniques. The NQR spectrometer consists of a homemade NMR console and an automatically tuned loop-gap resonator probe. The two factors which affect the ⁸¹Br NQR transition frequencies of brominated aromatics are: electron-donating and withdrawing substituents on the ring …

Analysis Of Near-Infrared Dye-Labeled Sanger Sequencing Fragments With Gel Electrophoresis Using The Time-Resolved Flourescence Lifetime Indentification Methods, Suzanne Jeanel Lassiter

LSU Doctoral Dissertations

The research presented in this dissertation involves the identification of sequencing fragments with time-resolved methods. For this application, near-infrared heavy-atom tricarbocyanine dyes were developed in our laboratory, which can be excited with a single laser and emission collected using a single detection channel. The dyes have four spectroscopically unique, but relatively short lifetimes that can be altered by the intramolecular heavy-atom they contain. The work described here involves the optimization of dye-primer chemistry for preparing Sanger sequencing reactions for longer reads and the optimization of the separation matrix for capillary gel electrophoresis that produces favorable statistical analysis of the aforementioned …