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Full-Text Articles in Physical Sciences and Mathematics
Electrochemiluminescence Mechanisms Investigated With Smartphone-Based Sensor Data Modeling, Parameter Estimation And Sensitivity Analysis, Elmer Ccopa Rivera, Rodney Lee Summerscales, Padma P. Tadi Uppala, Hyun J. Kwon
Electrochemiluminescence Mechanisms Investigated With Smartphone-Based Sensor Data Modeling, Parameter Estimation And Sensitivity Analysis, Elmer Ccopa Rivera, Rodney Lee Summerscales, Padma P. Tadi Uppala, Hyun J. Kwon
Faculty Publications
The present study introduces a unified framework combining a mechanistic model with a genetic algorithm (GA) for the parameter estimation of electrochemiluminescence (ECL) kinetics of the Ru(bpy)32+/TPrA system occurring in a smartphone‐based sensor. The framework allows a straightforward solution for simultaneous estimation of multiple parameters which can be, otherwise, time‐consuming and lead to non‐convergence. Model parameters are estimated by achieving a high correlation between the model prediction and the measured ECL intensity from the ECL sensor. The developed model is used to perform a sensitivity analysis (SA), which provides quantitative effects of the model parameters on the …
Development Of Smartphone-Based Ecl Sensor For Dopamine Detection: Practical Approaches, Hyun J. Kwon, Elmer Rivera, Mabio R. Cohelo Neto, Daniel Marsh, Jonathan Swerdlow, Rodney Lee Summerscales, Padma P. Tadi Uppala
Development Of Smartphone-Based Ecl Sensor For Dopamine Detection: Practical Approaches, Hyun J. Kwon, Elmer Rivera, Mabio R. Cohelo Neto, Daniel Marsh, Jonathan Swerdlow, Rodney Lee Summerscales, Padma P. Tadi Uppala
Faculty Publications
In this work, a compact, mobile phone-based ECL sensor apparatus was developed using the phone cameras, screen-printed electrodes (SPE), and mobile app for dopamine detection. Methods of DC voltage application for ECL reaction were comprehensively studied from the mobile phone itself or external power. Under optimized sensing conditions, with disposable carbon SPE and 20 mM coreactant tri-n-propylamine (TPrA), acceptable repeatability and reproducibility were achieved in terms of relative standard deviation (RSD) of intra- and interassays, which were 6.7 and 5.5%, respectively. The biochemical compound dopamine was measured due to its ECL quenching characteristics and its clinical importance. The …