Physical Sciences and Mathematics Commons^™

Design And Analysis Of Algorithms For Similarity Search Based On Intrinsic Dimension, Xiguo Ma

Dissertations

One of the most fundamental operations employed in data mining tasks such as classification, cluster analysis, and anomaly detection, is that of similarity search. It has been used in numerous fields of application such as multimedia, information retrieval, recommender systems and pattern recognition. Specifically, a similarity query aims to retrieve from the database the most similar objects to a query object, where the underlying similarity measure is usually expressed as a distance function.

The cost of processing similarity queries has been typically assessed in terms of the representational dimension of the data involved, that is, the number of features used …

Role Of Amyloid Beta Assembly State In The Human Immune Response, Deepa Viswanathan

Dissertations

Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disease that leads to dementia. Histopathological hallmarks that characterize AD are senile plaques formed by extracellular deposition of Amyloid beta (Aβ) peptide and intracellular aggregates of hyperphosphorylated tau protein. The plaques, which are found in the brain parenchyma, comprise both 40 and 42 residue Aβ. Aggregation of Aβ is an established pathogenic mechanism in AD, but little is known about the initiation of this process in vivo. Several studies have revealed significant inflammatory markers such as activated microglia and cytokines surrounding the plaques. Plaques are a hallmark of AD, but they are …

Activation Of The Innate Immune Response By The Alzheimer's Amyloid Beta Protein Via Toll-Like Receptors, Udan Lourdes Maria

Dissertations

Alzheimer’s Disease (AD) is the most common form of neurodegenerative disease characterized by the generation and deposition of amyloid beta plaques and the formation of neurofibrillary tangles. A wealth of data now demonstrate that inflammation is a prominent feature in AD pathology and a potential therapeutic target for the treatment and prevention of the disease. The emergence of evidence linking amyloid beta protein (Aβ), the primary component of senile plaques, to inflammation has led to new insights into understanding AD pathology. Aβ, a protein fragment resulting from cleavage of human amyloid precursor protein (APP), primarily exists in two forms: a …