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Design And Synthesis Of New Non-Steroidal Anti-Inflammatory Drugs With Anti-Cancer Activity On Colon Rectal Cancer Cell Lines Hct-116 And Caco-2, Wanda Ivette Rodríguez Rivera
Design And Synthesis Of New Non-Steroidal Anti-Inflammatory Drugs With Anti-Cancer Activity On Colon Rectal Cancer Cell Lines Hct-116 And Caco-2, Wanda Ivette Rodríguez Rivera
Dissertations
Colon rectal cancer is one of the most common types of cancer and is the third leading cause of cancer related deaths among western countries. Current chemotherapy treatments are highly toxic and mostly result in only a low percentage of tumor reduction; therefore an effective treatment with low toxicity is needed.
In this study, different innovative new COX-2 inhibitors were synthesized using the frame of biologically active chalcones to which active COX-2 pharmacophores SO2CH3, SO2NH2, SO2NHCOCH3 were added. Additionally, the effect of different alkyl chain lengths and the effect …