Physical Sciences and Mathematics Commons^™

Calculator Usage In Secondary Level Classrooms: The Ongoing Debate, Nicole Plummer

Honors College Theses

With technology becoming more prevalent every day, it is imperative that students gain enough experience with different technological tools in order to be successful in the “real-world”. This thesis will discuss the debate and overall support for an increased usage of calculators as tools in the secondary level classroom. When the idea of calculators in the classroom first came to life, many educators were very apprehensive and quite hesitant of this change. Unfortunately, more than 40 years later, there is still hesitation for their usage; and rightfully so. While there are plenty of advantages of calculator use in the classroom, …

Synthesis And Characterization Of New Gd3+-Containing Complexes As Potential Targeted Contrast Agents For Magnetic Resonance Imaging, Sashiprabha Manjari Vithanarachchi

Wayne State University Dissertations

The focus of the research described in this thesis is the study of chemistry relevant to target-specific contrast agents for magnetic resonance imaging (MRI). MRI is a widely used technique in diagnostic medicine and biomedical research to obtain anatomical and physiological details of soft tissues. Contrast agents are used to enhance the contrast of MR images by causing changes to the chemical environment of water molecules. Clinically approved GdIII-containing contrast agents for MRI are non-specific, and consequently, have limited utility. Target-specific contrast agents represent one way to circumvent this limitation. In the research described in this thesis, myelin and Β-amyloid …

Efficient Allocation And Enforcement Of Interfaces In Compositional Real-Time Systems, Farhana Dewan

Wayne State University Dissertations

Compositional real-time research has become one of the emerging trends in embedded and real-time systems due to the increasing scale and complexity of such systems. In this design paradigm, a large system is decomposed into smaller and simpler components, each of which abstracts their temporal requirements via interfaces. Such systems are mostly implemented by resource partitions to ensure that the components receive resources according to their interfaces. Potential implementations of a resource partition are via server-based interfaces or demand-based interfaces. In this context, our thesis in this dissertation is as follows:

Currently, server-based interfaces ensure strong temporal isolation among components …

Adaptive Stochastic Systems: Estimation, Filtering, And Noise Attenuation, Araz Ryan Hashemi

Wayne State University Dissertations

This dissertation investigates problems arising in identification and control of stochastic systems. When the parameters determining the underlying systems are unknown and/or time varying, estimation and adaptive filter- ing are invoked to to identify parameters or to track time-varying systems. We begin by considering linear systems whose coefficients evolve as a slowly- varying Markov Chain. We propose three families of constant step-size (or gain size) algorithms for estimating and tracking the coefficient parameter: Least-Mean Squares (LMS), Sign-Regressor (SR), and Sign-Error (SE) algorithms.

The analysis is carried out in a multi-scale framework considering the relative size of the gain (rate of …

Search For Contact Interactions Using The Dimuon Mass Spectrum In P-P Collisions At Sqrt(S) = 8 Tev At Cms, Chamath Kottachchi

Wayne State University Dissertations

The mass hierarchy problem associated with the standard model suggests that there might be more fundamental particles in nature. If quarks and leptons have substructures, known as preons, the manifestation of compositeness can be a four-fermion contact interaction. The experimental signal for contact interactions is a non-resonant enhancement of the number of events in the high-mass region of the dimuon mass spectrum. This dissertation describes a detailed search strategy for contact interactions using the Compact Muon Solenoid experiment. The dimuon mass spectrum above 300 GeV has been studied using the data collected in 2012 at sqrt(s) = 8 TeV corresponding …

Robust Regression Methods For Massively Decayed Intelligence Data, Akiva Joachim Lorenz

Wayne State University Dissertations

Homeland Security, sponsored by governmental initiatives, has become a vibrant academic research field. However, most efforts were placed with the recognition of threats (e.g. theory) and response options. Less effort was placed in the analysis of the collected data through statistical modeling. In a field that collects more than 20 terabyte of information per minute though diverse overt and covert means and indexes it for future research, understanding how different statistical models behave when it comes to massively decayed data is of vital importance.

Using Monte Carlo methods, three regression techniques (ordinary least squares, least-trimmed, and maximum likelihood) were tested …

Collective Flow And Azimuthally Differential Pion Femtoscopy With The Alice Experiment At The Lhc, Vera Reneee Loggins

Wayne State University Dissertations

Since 2009, the Large Hadron Collider (LHC) at European Organization

for Nuclear Research (CERN) has been conducting experiments in $pp$,

Pb-Pb, as well as $p$-Pb collisions with the center of mass energy

ranging $\sqrt{{s}_{NN}}=0.9-5.05$~TeV. In this thesis, both,

estimates of background correlations in anisotropic flow, $v_1-v_5$,

measurements

in Pb-Pb collisions at

$\sqrt{{s}_{NN}}=2.76$~TeV, and azimuthally differential pion femtoscopy

of Pb-Pb collisions are reported.

Two particle azimuthal correlations are statistically the most precise

method of measuring anisotropic flow. The main drawback of this method

is its sensitivity to the non-flow correlations, which unlike real

flow, do not have geometrical origin. Non-flow contribution …

Hiv-1 Rna Dimerization At Single Molecule Level, Hansini R. Mundigala

Wayne State University Dissertations

The Dimerization Initiation Sequence (DIS) is a conserved hairpin-loop motif on the 5' UTR of the HIV-1 genome. It plays an important role in genome dimerization through formation of a "kissing complex" intermediate between two homologous DIS sequences. This bimolecular kissing complex ultimately leads to the formation of an extended RNA duplex. Understanding the kinetics of this interaction is key to exploiting DIS as a possible drug target against HIV. We wish to report a novel study that makes an important contribution to understanding the dimerization mechanism of HIV-1 RNA in vitro. Our work has employed single-molecule fluorescence resonance energy …

Experimental And Theoretical Studies Of Binding Interactions In Divalent Transition Metal Cation-N-Donor Ligand Complexes: Structures, Sequential Bond Dissociation Energies, Mechanisms And Energetics Of Collision-Induced Dissociation, Holliness Nose

Wayne State University Dissertations

The thesis research described here involves a series of experiments that have been designed to probe the influence of the electronic structure of the metal cation, the nature and number of ligands, as well as the effects of chelation and steric interactions on the geometry and binding strength of transition metal cation-ligand complexes. The experimental studies make use of energy-resolved collision-induced dissociation (CID) techniques that are carried out in a custom-built guided ion beam tandem mass spectrometer (GIBMS) to probe the structures, energetics, and fragmentation behavior of the complexes of interest. Electronic structure theory calculations including several density functional theory …

Software Power Analysis And Optimization For Power-Aware Multicore Systems, Shinan Wang

Wayne State University Dissertations

Among all the factors in sustainable computing, power dissipation and energy consumption, arguably speaking, are fundamental aspects of modern computer systems. Different from performance metric, power dissipation is not easy to measure because hardware instrumentation is usually required. Yet as an indispensable component of a computer system, software becomes a major factor affecting power dissipation besides hardware energy-efficiency and power states. With detailed information on resource usage and power dissipation of an application/software, software developers will be able to leverage algorithms and implementations in order to produce power-efficient solutions. Hardware instrumentation, despite its accuracy, is costly and complicated to set …

Properties Of Nonlinear Randomly Switching Dynamic Systems: Mean-Field Models And Feedback Controls For Stabilization, Guangliang Zhao

Wayne State University Dissertations

This dissertation concerns the properties of nonlinear dynamic systems hybrid with Markov switching. It contains two parts. The first part focus on the mean-field models with state-dependent regime switching, and the second part focus on the system regularization and stabilization using feedback control. Throughout this dissertation, Markov switching processes are used to describe the randomness caused by discrete events, like sudden environment change or other uncertainty.

In Chapter 2, the mean-field models we studied are formulated by nonlinear stochastic differential equations hybrid with state-dependent regime switching. It originates from the phase transition problem in statistical physics. The mean-field term is …

Study On Endurance Of Flash Memory Ssds, Mochan Shrestha

Wayne State University Dissertations

Flash memory promises to revolutionize storage systems because of its massive performance gains, ruggedness, large decrease in power usage and physical space requirements, but it is not a direct replacement for magnetic hard disks. Flash memory possesses fundamentally different characteristics and in order to fully utilize the positive aspects of flash memory, we must engineer around its unique limitations. The primary limitations are lack of in-place updates, the asymmetry between the sizes of the write and erase operations, and the limited endurance of flash memory cells. This leads to the need for efficient methods for block cleaning, combating write amplification …

The Energy Trilogy: An Integrated Sustainability Model To Bridge Wastewater Treatment Plant Energy And Emissions Gaps, A. Adhim A. Altalibi

Wayne State University Dissertations

ABSTRACT

An estimated 4% of national energy consumption is used for drinking water and wastewater services. Despite the awareness and optimization initiatives for energy conservation, energy consumption is on the rise owing to population and urbanization expansion and to commercial and industrial business advancement. The principal concern is since energy consumption grows, the higher will be the energy production demand, leading to an increase in CO2 footprints and the contribution to global warming potential.

This research is in the area of energy-water nexus, focusing on wastewater treatment plant (WWTP) energy trilogy - the group of three related entities, which includes …

Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation, Aaron Kwaku Apawu

Wayne State University Dissertations

Dopamine (DA) neurons in the striatum mediate several functions of the brain and have been linked to a host of neurological disorders including Parkinson's disease and addiction, both of which occur as a result of dysfunction in the DA system. In the present study, our first objective was to understand how the striatal DA system adapts to acute and repeated administration of inhalant toluene. The use of toluene as inhalant, like other drugs of abuse, is known to perturb DA neurotransmission in the brain reward pathway. However, the exact mechanism underling toluene's influence on striatal DA neurotransmission is unknown. The …

On Ranked Approximate Matching Of Large Attributed Graphs, Mohammad Shafkat Amin

Wayne State University Dissertations

Many emerging database applications entail sophisticated graph based query manipulation, predominantly evident in large-scale

scientific applications. To access the information embedded in

graphs, efficient graph matching tools and algorithms have become of prime importance. Although the prohibitively expensive time

complexity associated with exact sub-graph isomorphism techniques has limited its efficacy in the application domain, approximate yet efficient graph matching techniques have received much attention due to their pragmatic applicability. Since public domain databases are noisy and incomplete in nature, inexact graph matching techniques have proven to be more promising in terms of inferring knowledge from numerous structural data repositories.

Contemporary …

Interference Modeling And Control In Wireless Networks, Xin Che

Wayne State University Dissertations

With the successful commercialization of IEEE802.11 standard, wireless networks have become a tight-knit of our daily life. As wireless networks are increasingly applied to real- time and mission-critical tasks, how to ensuring real-time, reliable data delivery emerges as an important problem. However, wireless communication is subject to various dynamics and uncertainties due to the broadcast nature of wireless signal. In particular, co-channel interfer- ence not only reduces the reliability and throughput of wireless networks, it also increases the variability and uncertainty in data communication [64, 80, 77].

A basis of interference control is the interference model which \emph{predicts} whether a …

Networks Of Users And Powers: Blackboard Software Roadmap As Cultural Practice, Diana Gellci

Wayne State University Dissertations

With the rapid growth of eLearning applications - the software providing for learning through the Internet - it has become commonplace to describe those technologies as both simple tools and user-friendly. These two vague yet suggestive terms make the operating of the technology appear as social value and any related issues as a user's problem. Interested neo-liberal groups take a step further when considering eLearning technologies as the solution for the problems faced in the field. STS studies recognize that technology fetishism is strategically employed to justify the latest developments of capitalism as technological and logical.

This doctoral study examines …

Alterations In The Mouse Striatum Following Acute And Repeated Ethanol Exposure, Brooke D. Newman

Wayne State University Dissertations

Brain-derived neurotrophic factor (BDNF) is an important neuromodulator that has implicated in regard to several neurological disorders, including alcohol addiction. BDNF is also an important modulator of dopamine (DA), a neurotransmitter that is heavily implicated in addiction with one of the DA rich brain regions being referred to as the reward center of the brain. One of the focuses in alcohol dependence research includes determining risk factors that make an individual more susceptible to becoming dependent. BDNF has been of interest as a risk factor due to its involvement in ethanol consumption and addiction evidenced in a vast number of …

Moser-Trudinger And Adams Type Inequalities And Their Applications, Nguyen Lam

Wayne State University Dissertations

In this dissertation, we study some variants of the Moser-Trudinger inequalities and Adams inequalities. The proofs of these inequalities relied crucially on the symmetrization arguments in the literature. By proposing new arguments and approaches, we develop successfully the critical versions of these well-known inequalities in many different settings where the rearrangement arguments may not be existed. As applications of our results, we also study in this dissertation the elliptic equations that contain the exponential nonlinearities.

Investigation Into The Binding Interactions Of Klenow Fragment To Dna Modified With Carcinogens Af And Aaf Using Surface Plasmon Resonance, Ashley M. Floyd

Wayne State University Dissertations

The two major forms of DNA adducts from the carcinogen N-acetoxyacetyl-2-aminofluorene, N-(deoxygunanonsin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) and N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF), are both known to impede replication, though in different ways. AAF is a strong block to replication leading to frameshift mutations, while the AF adduct is more easily bypassed, causing base substitutions. Surface plasmon resonance (SPR) was used to study the binding of exonuclease deficient E. coli polymerase I, Klenow fragment (KF), to DNA modified with AF or AAF at two locations: as a templating base or in the last formed base pair. KF binding to the modified DNA bases was also monitored to …

Development Of Silicon-Based Anodes And In-Situ Characterization Techniques For Lithium Ion Batteries, Jinho Yang

Wayne State University Dissertations

Development of lithium ion batteries (LIBs) with higher capacity has been booming worldwide, as growing concerns about environmental issues and increasing petroleum costs. The demands for the LIBs include high energy and power densities, and better cyclic stability in order to meet a wide range of applications, such as portable devices and electric vehicles. Silicon has recently been explored as a promising anode material due to its low discharge potential (<0.4 V) and high specific capacity (4200 mAh g^-1). The capacity of silicon potentially exceeds more than 10 times of the conventional graphite anode (372 mAh g^-1). However, the silicon anode experiences huge volume …

Using Large-Angle Beamstrahlung To Detect And Diagnose Colliding Beams For Luminosity Optimization, Hussein Farhat

Wayne State University Dissertations

The large-angle-beamstrahlung is a very effective technique that can be used to monitor two crossing beams. Monitoring the beam helps in analyzing and studying the beams profiles, allowing beams adjustments, and eventually leading to a perfect beams collision. The perfect beam collision results in a higher luminosity; as a result, a high particles production rate and new physics can be discovered.

Algorithms And Tools For Computational Analysis Of Human Transcriptome Using Rna-Seq, Nan Deng

Wayne State University Dissertations

Alternative splicing plays a key role in regulating gene expression, and more than 90% of human genes are alternatively spliced through different types of alternative splicing. Dysregulated alternative splicing events have been linked to a number of human diseases. Recently, high-throughput RNA-Seq technologies have provided unprecedented opportunities to better characterize and understand transcriptomes, in particular useful for the detection of splicing variants between healthy and diseased human transcriptomes.

We have developed two novel algorithms and tools and a computational workflow to interrogate human transcriptomes between healthy and diseased conditions. The first is a read count-based Expectation-Maximization (EM) algorithm and tool, …

Development Of Elisa-Based Hdac Activity Assay For Identification Of Isoform Selective Hdac Inhibitors, Geetha Padige

Wayne State University Dissertations

Cancers are one of the leading causes of death in United States, effecting roughly 20% of the population. To develop effective anti-cancer agents, vast research is in progress that targets various factors leading to cancer. One such area of cancer research is developing drugs that inhibit histone deacetylase (HDAC) proteins. HDACs are histone modifying enzymes that regulate transcription of genes. Aberrant recruitment of HDACs to the transcription factors leads to tumor onset and growth. Because of their potential anti-cancer therapeutic interest, several HDAC inhibitors are in various stages of clinical trials. SAHA and Romidepsin are FDA-approved drugs for the treatment …

Building A Scalable And High-Performance Key-Value Store System, Yuehai Xu

Wayne State University Dissertations

Contemporary web sites can store and process very large amounts of data. To provide timely service to their users, they have adopted key-value (KV) stores, which is a simple but effective caching infrastructure atop the conventional databases that store these data, to boost performance. Examples are Facebook, Twitter and Amazon. As yet little is known about the realistic workloads outside of the companies that operate them, this dissertation work provides a detailed workload study on Facebook's Memcached, which is one of the world's largest KV deployment. We analyze the Memcached workload from the perspective of server-side performance, request composition, caching …

Correlation Effects In Nanoparticle Composites: Percolation, Packing And Tunneling, Rupam Mukherjee

Wayne State University Dissertations

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Environmental Stressors: Pathways Of Exposure And Aquatic Invertebrate Response, Carly Jean Nowicki

Wayne State University Dissertations

The need to monitor freshwater and detect impairments prior to observable impacts is crucial to maintain species diversity and ecosystem function. Therefore, understanding the contribution of various matrices (i.e., sediment and water) to chemical exposure is critical for remediation of impacted sites.

To evaluate various matrices of chemical exposure, I focused on the organic pollutant polychlorinated biphenyls (PCBs) due to their relatively ubiquitous nature, high toxicity, and adverse effects on humans and wildlife. In complementary laboratory and field experiments, I compared the effects of aqueous versus sedimentary exposure of PCBs on invertebrates. In the laboratory, organisms exposed to PCB-contaminated sediments …

Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media, Derek James Averill

Wayne State University Dissertations

The formation of carbon-carbon bonds is of great interest to synthetic chemists because these bonds make up the majority of biologically active compounds. The Mukaiyama aldol reaction is a Lewis-acid-catalyzed carbon-carbon bond-forming reaction that has the ability to produce optically active β-hydroxy carbonyls which can be found in many pharmaceuticals and natural products. Because of precatalyst instability towards hydrolysis, anhydrous solvents are commonly used. Recent efforts have focused on water-tolerant versions of enantioselective Mukaiyama aldol reactions because of the financial and environmental benefits of using aqueous media. Consequently, the Lewis-acidic and water-tolerant features of Ln³⁺ ions have aroused great …

Probing Proteasome Inhibition By Metal Copmplexes As A New Route For Anticancer Therapy, Dajena Tomco

Wayne State University Dissertations

The scope of this thesis is focused towards the development of metal-containing coordination compounds as potential therapeutic agents. Efforts of this research involve the design, synthesis, and purification of these complexes, as well as their evaluation by spectroscopic, spectrometric, and electrochemical characterization. The antineoplastic properties of these metal-containing pro-drugs are tested against the inhibition activity of the 26S proteasome. Selected metal ions ranging from transition to main group elements have been incorporated in various ligand systems containing phenolate and pyridyl donor sets. The mechanistic behavior of these complexes in solution has been thoroughly investigated along with their in vitro anticancer …

Theoretical And Experimental Studies Of Noncovalent Metal Cation Binding And Base Pairing Interactions Of Cytosine And Modified Cytosines, Bo Yang

Wayne State University Dissertations

ABSTRACT

THEORETICAL AND EXPERIMENTAL STUDIES OF NONCOVALENT METAL CATION BINDING AND BASE PARING INTERACTIONS OF CYTOSINE AND MODIFIED CYTOSINES

by

BO YANG

December 2014

Advisor: Professor Mary T. Rodgers

Major: Analytical Chemistry

Degree: Doctor of Philosophy

Binding of metal cations to the nucleobases can lead to formation of rare tautomers of the nucleobases. The infrared multiple photon dissociation (IRMPD) action spectroscopy of five alkali metal cation-cytosine complexes, M⁺(cytosine), where M⁺ = Li⁺, Na⁺, K⁺, Rb⁺, and Cs⁺, are examined using a Fourier transform ion cyclotron resonance mass …