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Full-Text Articles in Physical Sciences and Mathematics
Multiblock Discriminant Analysis For Integrative Genomic Study, Mingon Kang, Dong-Chul Kim, Chunyu Liu, Jean Gao
Multiblock Discriminant Analysis For Integrative Genomic Study, Mingon Kang, Dong-Chul Kim, Chunyu Liu, Jean Gao
Computer Science Faculty Publications and Presentations
Human diseases are abnormal medical conditions in which multiple biological components are complicatedly involved. Nevertheless, most contributions of research have been made with a single type of genetic data such as Single Nucleotide Polymorphism (SNP) or Copy Number Variation (CNV). Furthermore, epigenetic modifications and transcriptional regulations have to be considered to fully exploit the knowledge of the complex human diseases as well as the genomic variants. We call the collection of the multiple heterogeneous data “multiblock data.” In this paper, we propose a novel Multiblock Discriminant Analysis (MultiDA) method that provides a new integrative genomic model for the multiblock analysis …
Universal Computation With Arbitrary Polyomino Tiles In Non-Cooperative Self-Assembly, Sándor P. Fekete, Jacob Hendricks, Matthew J. Patitz, Trent A. Rogers
Universal Computation With Arbitrary Polyomino Tiles In Non-Cooperative Self-Assembly, Sándor P. Fekete, Jacob Hendricks, Matthew J. Patitz, Trent A. Rogers
Computer Science Faculty Publications and Presentations
In this paper we explore the power of geometry to overcome the limitations of non-cooperative self-assembly. We define a generalization of the abstract Tile Assembly Model (aTAM), such that a tile system consists of a collection of polyomino tiles, the Polyomino Tile Assembly Model (polyTAM), and investigate the computational powers of polyTAM systems at temperature 1, where attachment among tiles occurs without glue cooperation (i.e., without the enforcement that more than one tile already existing in an assembly must contribute to the binding of a new tile). Systems composed of the unit-square tiles of the aTAM at temperature 1 …