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Characterization Of Sufs And Sufe Of Suf Pathway For Fe-S Cluster Assembly In Escherichia Coli, Guangchao Dong
Characterization Of Sufs And Sufe Of Suf Pathway For Fe-S Cluster Assembly In Escherichia Coli, Guangchao Dong
Theses and Dissertations
Fe-S clusters are one major type of the sulfur-containing cofactors, which conduct essential functions in organisms. The Suf pathway is one of the three main pathways for the biosynthesis of Fe-S clusters. In E. coli, the Suf pathway is utilized under iron limitation and oxidative stress. This ability is important for pathogens to survive. Also, the Suf pathway is found to be exclusive in bacteria, so it is a good target for novel antibiotic design. SufS is a cysteine desulfurase in the Suf pathway to extract sulfur from L-cysteine. It needs the enhancement of SufE. To better understand the catalytic …
Characterization Of The Suf Fe-S Pathway In Escherichia Coli, Naimah Bolaji
Characterization Of The Suf Fe-S Pathway In Escherichia Coli, Naimah Bolaji
Theses and Dissertations
Iron is an essential transition metal required by almost all organisms for use as a cofactor in many metabolic processes such as respiration and photosynthesis. Iron can be combined with elemental sulfur to form an iron-sulfur (Fe-S) cluster. In bacterial pathogens, Fe-S cluster cofactors carry out critical functions and the Fe-S cluster biogenesis pathway is essential for their survival. In E. coli, the Suf pathway assembles Fe-S clusters under conditions of iron starvation and oxidative stress. While some mechanistic details of the Fe-S cluster biogenesis have been well-characterized, the process of in vivo iron donation remains unclear. Iron storage proteins …