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Full-Text Articles in Physical Sciences and Mathematics
Chemical Processes Governing The Equilibrium Between Organic And Inorganic Carbon: Probing The Mechanisms Of Iron Catalyzed Reactive Oxygen Species Production, Joy Kelechi Ihekweazu
Chemical Processes Governing The Equilibrium Between Organic And Inorganic Carbon: Probing The Mechanisms Of Iron Catalyzed Reactive Oxygen Species Production, Joy Kelechi Ihekweazu
Theses and Dissertations
This study examines the oxidation of organic carbon that occurs concurrently with the autoxidation of Fe(II) to determine the role that geochemical constituents have on both the autoxidation of Fe(II) and subsequent ROS production. The reaction between reduced carbon and oxygen is thermodynamically favorable, but kinetically proceeds slowly. Fe(II) facilitates the equilibration of reduced carbon and oxygen. This equilibration occurs naturally in saline estuaries, where oxygen rich seawater mixes with anoxic groundwater. We characterized a saline estuary at the Baruch Institute and used those characterizations to recreate natural water conditions in the lab. Using simulated natural water we then examined …
The Role Of Intermembrane Space Redox Factors In Glutathione Metabolism And Intracellular Redox Equilibrium, Hatice Kubra Ozer
The Role Of Intermembrane Space Redox Factors In Glutathione Metabolism And Intracellular Redox Equilibrium, Hatice Kubra Ozer
Theses and Dissertations
The mitochondrial intermembrane space (IMS) is a unique subcellular compartment that houses key thiol-dependent redox pathways such as protein transport, mitochondrial respiration, and detoxification of ROS (reactive oxygen species). These pathways are all dependent on cysteine-rich proteins, thus maintaining thiol-disulfide balance in this organelle is crucial for cellular functions. An IMS protein import pathway called the Mia40-Erv1 disulfide relay system uses disulfide bond formation for the import and retention of substrate proteins in the IMS. Erv1 is also suggested to be involved in maturation of cytosolic Fe-S cluster proteins and regulation of iron homeostasis in S. cerevisiae. However, these studies …