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Full-Text Articles in Physical Sciences and Mathematics
Lomustine Analogous Drug Structures For Intervention Of Brain And Spinal Cord Tumors: The Benefit Of In Silico Substructure Search And Analysis, Ronald Bartzatt
Lomustine Analogous Drug Structures For Intervention Of Brain And Spinal Cord Tumors: The Benefit Of In Silico Substructure Search And Analysis, Ronald Bartzatt
Chemistry Faculty Publications
Lomustine is a nitrosourea anticancer agent shown to be effective for treatment of childhood medulloblastoma. In silico substructure searches produced 17 novel nitrosourea agents analogous to lumustine and retaining activity for DNA alkylation and cytotoxic activity. The mean values for Log P, polar surface area, formula weight, number of oxygens & nitrogens, and rotatable bonds were 2.524, 62.89 Anstroms2, 232.8, 5, and 2, respectively. All 17 agents have formula weight less than 450 and Log P less than 5, two criteria preferred for blood-brain barrier penetration.These agents have a polar surface area less than 90 Angstroms2. Each show zero violations …
Test Selection On Extended Finite State Machines With Provable Guarantees, Bo Guo, Mahadevan Subramaniam
Test Selection On Extended Finite State Machines With Provable Guarantees, Bo Guo, Mahadevan Subramaniam
Chemistry Faculty Publications
Building high confidence regression test suites to validate new system versions is a challenging problem. A model- based approach to build a regression test suite from a given test suite is described. The generated test suite includes every test that will traverse a change performed to produce the new version, and consists of only such tests to reduce the testing costs. Finite state machines extended with typed variables (EFSMs) are used to model systems and system changes are mapped to EFSM transition changes adding/deleting/replacing EFSM transitions and states. Tests are a sequence of input and expected output messages with concrete …