Physical Sciences and Mathematics Commons^™

Synthesis And Characterization Of Imidazolium Salt Derivatives For Anti-Tumor Activity, Ryan W. Pearce

Williams Honors College, Honors Research Projects

Several aldehydes (butanal, pentanal, hexanal, 4-hydroxybenzaldehyde) were reacted with 1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (1) to produce novel C² substituted imidazolium salts for the potential use against non-small cell lung cancer in humans. Compounds 2-(1-hydroxypentyl)-1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (3) and 2-(1-hydroxyhexyl)-1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (5) were successfully synthesized with structures supported by NMR and mass spectrometry. Characterization by ¹H NMR showed evidence of 1 in both compounds. The tumor cell growth inhibition of 3 against non-small cell lung cancer lines NCI-A549, NCI-H460, HCC827, and NCI-H1975 was tested and found to be comparable to cisplatin as measured by MTT assay. …

In Game Engine Documentation, Zachary A. Pierce

Williams Honors College, Honors Research Projects

The In Game Engine is a game that simulates the functionality of a game engine through simple tasks such as entity creation, interaction, management, and behavior through a user interface. The project was created in the Unreal Engine and utilizes the Blueprints Visual Scripting system to handle these tasks for developers.

Electronic Health Record Simulator, Samuel M. Brown

Williams Honors College, Honors Research Projects

The Electronic Health Record Simulator is exactly that; it is meant to simulate an EHR (like those found in hospitals and clinics) for use in an academic setting. Its purpose is to familiarize students with the operation of real-world EHRs in order to better prepare them for the workforce. It allows instructors to create fictional patients (with full lab values), and allows students to fill in information as in a real EHR.

Determination Of The Structure Of Sphingomyelin By Tandem Mass Spectrometry And Matrix - Assisted Laser Desorption/Ionization, Antonio Ganios

Williams Honors College, Honors Research Projects

Mass spectrometry is a method that uses masses to determine the structure of a compound. This is completed by first charging the compound until it is a cation or anion, and then its molecular weight can be determined by measuring a mass to charge ratio. The focus of this study was determination of sphingomyelin’s structure. The purpose of this was that sphingomyelin has been shown to play a critical role in many biological pathways and being able to identify this lipid could prove to be beneficial for preventative medicine. Utilizing electrospray ionization (ESI) Quadruple-Time-of-flight (Q-TOF) mass spectrometry on a Waters …

Enhanced Child’S Play Lan Design, Nicholas B. Bordo

Williams Honors College, Honors Research Projects

Child’s Play is a charity event hosted by the student chapter of the Association for Computing Machinery at the University of Akron. This event allows people to compete in various video game tournaments while simultaneously raising money for charity. In order to make this possible, a network is crucial. However, in previous years, the performance has been poor. The goal of this project is to implement a new network design which will offer more functionality and reliability than in previous years. This network will be able to operate completely inside of an existing network on a temporary basis. This design …

Biodegradable Poly(Ester Urea's) Scaffold Sponges Containing Platelet-Rich Plasma For Targeted Tendon-Bone Fixation, Alex B. Ellenberger Mr.

Williams Honors College, Honors Research Projects

In this report the synthesis and characterization of L-valine and L-isoleucine poly(ester ureas) (PEUs) for future use in the synthesis of biodegradable PEUs sponges will be discussed. The method of monomer and polymer synthesis will be explained along with the characterization of the monomer and polymer products. This characterization will be done by the use of Nuclear Magnetic Resonance (NMR) and Size Exclusion Chromatography (SEC). NMR is a quick and convenient method for determining structure and purity of the monomer and polymer products. SEC gives the number average molecular weight, which is the statistical average molecular weight of all the …

An Examination Of Mathematical Models For Infectious Disease, David M. Jenkins

Williams Honors College, Honors Research Projects

Starting with the original 1926 formulation of the SIR (Susceptible-Infected-Removed) model for infectious diseases, mathematical epidemiology continued to grow. Many extensions such as the SEIR, MSIR, and MSEIR models were developed using SIR as a basis to model diseases in a variety of circumstances. By taking the original SIR model, and reducing the system of three first-order equations to a single first-order equation, analysis shows that the model predicts two possible situations. This analysis is followed by discussion of an alternative use of the SIR model which allows for one to track the amount of sustainable genetic variation in a …

Application Of Lipid Styryl Dye For Staining Intracytoplasmic Membranes In Gram-Negative Bacteria, Theodore J. Hammer

Williams Honors College, Honors Research Projects

Intracytoplasmic membranes are structures that form within cells which help facilitate a variety of different metabolic processes. This feature of intracellular membranes makes them particularly valuable for studying compartmentalization and cell dynamics in bacteria. In the past, transmission electron microscopy has been the primary method for imaging bacteria with intracytoplasmic membranes. Because transmission electron microscopy takes images of a cell in fixed slices, it’s impossible to follow a cell’s growth and development over time. Fluorescence microscopy is a particularly effective method of measurement that can combat these issues when evaluating live bacterial cells. Here, standard biochemical laboratory procedures were used …

Humidity And Rest Period Effects On Viscid Silk Recovery, Catherine Donley

Williams Honors College, Honors Research Projects

Spider silk applications, and applications of composite materials generally, are limited due to lack of recovery once damaged. Viscid silk, however, is known to have self-healing capabilities which restore, at least partially, its initial properties. If maximized, this ability could potentially increase viscid silk’s practicality and ultimately, provide insight into a self-healing system of use in synthetics. To that end, samples of viscid silk spun by female Larinioides cornutus spiders were tested via cyclical loading at 3 different relative humidities, with 3 different rest period lengths between complete cycles. Data from previously-performed tensile tests conducted at the same 3 humidities …

An Investigation In Implementing A C++ Voxel Game Engine With Destructible Terrain, Michael W. Wilder

Williams Honors College, Honors Research Projects

In video games today, world geometry is often represented as a polygon mesh. While this representation is able to represent terrain, it must be done so using an elevation grid. For each X and Z location, an elevation grid stores the height of the terrain at that location. This has a major drawback: it is unable to allow terrain with overhangs and caves, and is unable to allow for destructible terrain. In this project, an alternative technique using voxels is explored to overcome these limitations for a game engine. A voxel is the 3D equivalent of a pixel and allows …

Synthesis, Characterization And Anti-Proliferative Activity Of An Imidazolium Salt And Its Silver Carbene Complex: Utilization Of Picolyl And Quinolylmethyl Substituents, Cari E. Molnar

Williams Honors College, Honors Research Projects

The imidazolium salt (IS) and silver carbene complex (SCC) studied in this report are 3-(pyridin-2-ylmethyl)-1-(quinolin-2-ylmethyl)imidazolium chloride (1) and 3-(pyridin-2-ylmethyl)-1-(quinolin-2-ylmethyl)imidazole – silver acetate complex (2). It was anticipated that the anti-proliferative activity of 1 and 2 would be similar to other characterized ISs while having increased solubility. The SCC (2) was synthesized in order to simulate the ligand-metal coordination similar to that of cisplatin.

The success of the synthetic processes of 1 and 2 were determined by ¹H NMR (300 MHz) spectroscopy. In addition, 1 was also characterized by ¹H NMR (500 MHz) …

The Effects Of Substrate Roughness In Air And Water On The Gecko Adhesive System, Amanda Palecek

Williams Honors College, Honors Research Projects

In an effort to better understand the fascinating gecko adhesive system, scientists have long tested the abilities of the gecko in controlled conditions that mimic the gecko’s native environment. The effects of humidity, environmental temperature, and exposure to water have all been tested. Roughness, however has not been studied in great detail. Surfaces of varying roughnesses are all over the gecko’s natural environment. We tested geckos on hydrophilic silicon carbide sandpapers of varying roughnesses in both air and water to attempt to better study the effects of roughness on gecko adhesion. When tested on the rougher (1 µm) surface, the …

Evaluation Of The Signature Molecular Descriptor With Blosum62 And An All-Atom Description For Use In Sequence Alignment Of Proteins, Lindsay M. Aichinger

Williams Honors College, Honors Research Projects

This Honors Project focused on a few aspects of this topic. The second is comparing the molecular signature kernels to three of the BLOSUM matrices (30, 62, and 90) to test the accuracy of the mathematical model. The kernel matrix was manipulated in order to improve the relationship by focusing on side groups and also by changing how the structure was represented in the matrix by increasing the initial height distance from the central atom (Height 1 and Height 2 included).

There were multiple design constraints for this project. The first was the comparison with the BLOSUM matrices (30, 62, …

Synthesis And Anti-Proliferative Activity Of N,N’-Bis(Arylmethyl)Benzimidazolium Salts, Travis M. Williams

Williams Honors College, Honors Research Projects

A series of N,N’-bis(arylmethyl)benzimidazolium salts with hydrophilic and lipophilic substituents have been synthesized, characterized, and tested against select non-small cell cancer cell lines. Substituent variations on the imidazole ring have shown that lipophilicity and hydrophilicity can influence the imidazolium salts’ anti-proliferative activity and aqueous solubility.

Characterization Of Noncovalent Complexes Of Polyelectrolytes By Mass Spectrometry, Anthony J. Marino

Williams Honors College, Honors Research Projects

Various ions of poly-L-lysine and polystyrene sulfonic acid were successfully observed first within a matrix-assisted laser desorption/ionization mass spectrometer and subsequently in an electrospray ionization mass spectrometer. The successful ionization of these polymers allowed for studies to be performed on the noncovalent interactions between the two. Noncovalent interactions were effectively studied on both instruments, but further quantified using tandem mass spectrometry found within the MALDI system and ion-mobility mass spectrometry found within the electrospray ionization system. As a result of employing the use of ion-mobility, various different stoichiometries and charges of polyelectrolyte complexes could be distinguished.

Origins Of Life On Earth: Mineral Effects On Vesicle Formation And Permeability, Jacob Morris

Williams Honors College, Honors Research Projects

Understanding how life could have emerged on Earth is a very old problem that is still far from being resolved. Minerals have long been proposed to play a role in the formation of the first cell, but only few experimental data were reported concerning the mineral-lipid interactions. In the present work, calcein leakage assay, a fluorescence based experiment, and dynamic light scattering measurements were used to examine the effects of mineral properties and of MgCl₂ on the formation and the stability of vesicles formed from single-chain amphiphiles (SCA), which are believed to have been present on early Earth. The …

Philosophy Of Mathematics: Theories And Defense, Amy E. Maffit

Williams Honors College, Honors Research Projects

In this paper I discuss six philosophical theories of mathematics including logicism, intuitionism, formalism, platonism, structuralism, and moderate realism. I also discuss problems that arise within these theories and attempts to solve them. Finally, I attempt to harmonize the best features of moderate realism and structuralism, presenting a theory that I take to best describe current mathematical practice.

Honors Project Database Ui Redesign, Fred L. Johnson Jr.

Williams Honors College, Honors Research Projects

For my Honors Project I designed a new user interface for the Honors Project Database on the Honors College website. I also developed training materials for the Honors College staff and facilitated a training session for them that showed them how to keep the database updated.

Creation Of A Portable, 3d-Printable, Iphone-Compatible Spectrophotometer, Elise K. Grasse

Williams Honors College, Honors Research Projects

Spectroscopy is a widely used chemical and medical analysis tool. While spectrophotometers are commonly found in many universities and laboratories, they are not available to all high schools or laboratories in developing countries. The objective of this project was to design a high-quality, 3D-printable, iPhone-compatible spectrophotometer that uses a cell phone camera and interface to collect data. The created 3D-print file will be available to anyone with access to a 3D printer which are increasingly found in many laboratories and schools across the country. A low cost pre-printed kit will also be made for those without access to a 3D …

Analysis Of Password Cracking Methods & Applications, John A. Chester

Williams Honors College, Honors Research Projects

This project examines the nature of password cracking and modern applications. Several applications for different platforms are studied. Different methods of cracking are explained, including dictionary attack, brute force, and rainbow tables. Password cracking across different mediums is examined. Hashing and how it affects password cracking is discussed. An implementation of two hash-based password cracking algorithms is developed, along with experimental results of their efficiency.

Investigating Use Of Beta Coefficients For Stock Predictions, Jeffrey Swensen

Williams Honors College, Honors Research Projects

By using previous stock market data, investors can get a good sense of how to invest for the future. A common way to determine what stocks are riskier than others is by using the beta coefficient. This paper investigates the relationship between the overall S&P 500 market and certain individual stocks to see if we can use past stock return data to predict the future riskiness of certain stocks. Correlation between the individual stocks and the S&P 500 will allow us to determine the relationship between the two. Finding the beta coefficients for the individual stock market will allow investors …

Constrained Templates In C++, Braden L. Obrzut

Williams Honors College, Honors Research Projects

This paper seeks to answer what C++ concepts are, the benefit they provide to C++ programmers, and where we would like to go looking ahead. To accomplish this, it will examine the current state of generic programming in C++, look at what other languages do to avoid the issue, and how concepts can be used to solve the problem in a manner which provides more freedom to the programmer. In the general sense, concepts allow the programmer to specify preconditions which must be satisfied on the inputs to generic code. The desire being to fully describe what is required by …

Sharp Rna Recognition Motif Optimizations, Extensions, And Mutations For Use In 2d And 3d Nmr Experiments, Shaun M. Christie

Williams Honors College, Honors Research Projects

SMRT/HDAC Associated Repressor Protein interacts with the long noncoding RNA, produced by SRA, by binding at the RRMs. Three projects were done to prepare the truncated proteins for use in 2D and 3D NMR experiments. The first focuses on RRM 3 and its optimization during the purification process. The second focuses on RRM 2-4, which was found to be missing two alpha helices that may be important for protein stability. These helices can also interact with RRM 3 as well due to the tight association of RRMs 3 and 4. The two step PCR extension of RRM 2-4 was assumed …

Gene Expression Of Tissue-Engineered Distal Phalanx Models Utilizing Polymer Scaffolds With Hydroxyapatite And Beta-Tricalcium Phosphate, Kristrun H. Kristinsdottir, William J. Landis Ph.D., Robin Jacquet M.S.

Williams Honors College, Honors Research Projects

Tissue engineering is a scientific methodology that provides the means for fabrication of vital tissues in a laboratory with the ultimate goal of translating the tissue to a patient in a clinic. It is a desirable technique in clinical medicine because it eliminates the need for patient tissue grafts and transplants, which have the potential for donor site morbidity and rejection. In tissue engineering, the scaffolding material, typically a polymer upon which tissue is grown, is important. The goal of this research is to investigate optimization of tissue-engineered polymer scaffold constructs for cell proliferation and gene expression. This work includes …

The Relationship Among Math Anxiety, Mathematical Performance, And Math Education In Undergraduate Nursing Students, Joshua D. Beall, Troy Roebuck, Paul Penkalsky

Williams Honors College, Honors Research Projects

Although nurses spend up to 40% of their day calculating and administering medication doses, undergraduate nursing students often perform poorly on nursing math exams. The purpose of this study was (a) to examine the relationship among mathematical education, performance, and anxiety and (b) to compare the mathematical education, performance, and anxiety in sophomore and senior baccalaureate nursing students at a public university in the Midwest. This cross-sectional, descriptive study was guided by Bandura's self-efficacy theory. Math performance was measured with an 11-item math instrument, math education was measured with number of math courses, and math anxiety was measured with Fennema–Sherman …

Reactions Of Hexachlorocyclotriphosphazene And Lewis Bases To Produce [Pon]3: Methanesulfonic Acid And Dimethylformamide Reactions With [Pcl2n]3, Savannah R. Snyder

Williams Honors College, Honors Research Projects

Several chlorine/oxygen exchange reactions of [PCl₂N]₃ were investigated with the goal of forming [PON]₃, a precursor to PON materials. The reaction of MeSO₃H and Et₃N with hexachlorocyclotriphosphazene ([PCl₂N]₃) has been claimed to produce a [PON]₃ single molecule. This reaction could not be reproduced. Only partially oxygenated phosphazenes have been obtained. Similarly, in the reaction of [PCl₂N]₃ and dimethylformamide (DMF) both partial and full oxygenation occurs. Stoichiometry appears to be crucial in determining the species that is produced in both reactions. These products were …

Modeling The Progress And Retention Of International Students Using Markov Chains, Lucas Gagne

Williams Honors College, Honors Research Projects

International students are a small and diverse student population present in any sizable American university. One of the greatest obstacles in their path is the acquisition of the English language. English for Academic Purposes (EAP) programs, such as the English Language Institute (ELI) at the University of Akron, attempt to address this problem. By studying how this student population progresses in their academic studies, EAP programs and their associated universities can make well-informed decisions on how best to serve their English Language Learners. One way to study International students is through the use of a Markov model based on university …

Parameters Estimation Of Material Constitutive Models Using Optimization Algorithms, Kiswendsida Jules Kere

Williams Honors College, Honors Research Projects

Optimization Algorithms are very useful for solving engineering problems. Indeed, optimization algorithms can be used to optimize engineering designs in terms of safety and economy. Understanding the proprieties of materials in engineering designs is very important in order to make designs safe. Materials are not really perfectly homogeneous and there are heterogeneous distributions in most materials. In this paper, Self-OPTIM which is an inverse constitutive parameter identification framework will be used to identify parameters of a linear elastic material constitutive model. Data for Self-OPTIM will be obtained using ABAQUS simulation of a dog-bone uniaxial test. Optimization Algorithms will be used …

Creating A Mobile Game, Timothy Jasany

Williams Honors College, Honors Research Projects

The world we live in today is one that revolves around technology. Whether you are checking your email or paying a bill, most of these actions can be accomplished through the use of technology. One of the most powerful pieces of technology is a cell phone, which can accomplish most tasks any other device can do. Since this piece of technology is growing better and better each day I decided to learn how to program android devices. Cell phones are becoming more widely used by the general public, which I think means that in the near future that cell phones …