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The Interaction Of Adipose Derived Stem Cells And Breast Cancer, Natasha Cunningham, Ava O'Meara, Cathy L. Brougham
The Interaction Of Adipose Derived Stem Cells And Breast Cancer, Natasha Cunningham, Ava O'Meara, Cathy L. Brougham
SURE Journal: Science Undergraduate Research Experience Journal
Introduction: Mesenchymal stem cells are adult stem cells capable of self-renewal and multilineage differentiation (Schweizer et al., 2015). Adipose derived stem cells have been used in breast reconstruction following surgical intervention in breast cancer patients. MicroRNAs have been linked to gene regulation essential in oncogenic, and tumour suppression as well as cell signalling pathways in BC.
Aim: To research the hypothesis of ADSCs and their therapeutic properties in BC patients.
Methods: Proliferation assays were carried out to demonstrate how ADSC conditioned media influenced BC cell lines MDA-MB-231, SKBR3, and T47D. The expression of six miRNAs (miR-21, miR-133, miR-222, miR-146, miR-221, …