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Full-Text Articles in Physical Sciences and Mathematics
Active Presecription Drug Safety Surveillance: Exploring Omop 2011-2012 Experiments, Susan Gruber, James M. Robins
Active Presecription Drug Safety Surveillance: Exploring Omop 2011-2012 Experiments, Susan Gruber, James M. Robins
Susan Gruber
The Observational Medical Outcomes Partnership (OMOP), a consortium of pharmaceutical, FDA, and academic researchers focuses on developing and evaluating electronic records-based methods for enhancing post-market drug safety surveillance. The OMOP 2011-2012 experiment consists of applying variants of seven analysis methods to five different EMR or claims databases to estimate the increase (decrease) in risk associated with drug-outcome pairs whose causal association has been previously established, and serves as a gold standard for comparison. Variants of each method can produce very different effect estimates, sometimes at odds with the gold standard. We explore the reasons behind this heterogeneity, and in doing …
A Targeted Confounder Selection Strategy For Propensity Score Estimation, Susan Gruber
A Targeted Confounder Selection Strategy For Propensity Score Estimation, Susan Gruber
Susan Gruber
These slides provide an introduction to data-adaptive propensity score estimation, and the collaborative targeted maximum likelihood estimator (C-TMLE) of van der Laan and Gruber. The notation has been greatly simplified, which makes the work accessible to a more general audience, but loses a little in the translation.
An Overview Of Targeted Maximum Likelihood Estimation, Susan Gruber
An Overview Of Targeted Maximum Likelihood Estimation, Susan Gruber
Susan Gruber
These slides provide an introduction to targeted maximum likelihood estimation in a point treatment setting.