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Full-Text Articles in Physical Sciences and Mathematics
Graduate Colloquium, Borbala Mazzag
The Effect Of Residual Ca2+ On The Stochastic Gating Of Ca2+-Regulated Ca2+ Channel Models, Borbala Mazzag, Christoper J. Tignanelli, Gregory D. Smith
The Effect Of Residual Ca2+ On The Stochastic Gating Of Ca2+-Regulated Ca2+ Channel Models, Borbala Mazzag, Christoper J. Tignanelli, Gregory D. Smith
Borbala Mazzag
Single channel models of intracellular Ca2+ channels such as the inositol 1,4,5-trisphosphate
receptor and ryanodine receptor often assume that Ca2+-dependent transitions are mediated
by a constant background [Ca2+] as opposed to a dynamic [Ca2+] representing the formation
and collapse of a localized Ca2+ domain. This assumption neglects the fact that Ca2+ released
by open intracellular Ca2+ channels may influence subsequent gating through the processes
of Ca2+-activation or Ca2+-inactivation. We study the effect of such “residual Ca2+” from
previous channel opening on the stochastic gating of minimal and realistic single channel
models coupled to a restricted cytoplasmic compartment. Using Monte-Carlo simulation …