Physical Sciences and Mathematics Commons^™

Formation Of Microcages From A Collagen Mimetic Peptide Via Metal-Ligand Interactions, Jeremy Gleaton, Ryan W. Curtis, Jean Chmielewski

Department of Chemistry Faculty Publications

Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.

Catalytic Pyrolysis Of Lignin Model Compounds (Pyrocatechol, Guaiacol, Vanillic And Ferulic Acids) Over Nanoceria Catalyst For Biomass Conversion, Nataliia Nastasiienko, Tetiana Kulik, Borys Palianytsia, Julia Laskin, Tetiana Cherniavska, Mykola Kartel, Mats Larsson

Department of Chemistry Faculty Publications

Understanding the mechanisms of thermal transformations of model lignin compounds (MLC) over nanoscale catalysts is important for improving the technologic processes occurring in the pyrolytic conversion of lignocellulose biomass into biofuels and value-added chemicals. Herein, we investigate catalytic pyrolysis of MLC (pyrocatechol (P), guaiacol (G), ferulic (FA), and vanillic acids (VA)) over nanoceria using FT-IR spectroscopy, temperature-programmed desorption mass spectrometry (TPD MS), and thermogravimetric analysis (DTG/DTA/TG). FT-IR spectroscopic studies indicate that the active groups of aromatic rings of P, G, VA, and FA as well as carboxylate groups of VA and FA are involved in the interaction with nanoceria surface. …

Amino Alkynylisoquinoline And Alkynylnaphthyridine Compounds Potently Inhibit Acute Myeloid Leukemia Proliferation In Mice, N Naganna, Clement Opuku-Temeng, Eun Yong Choi, Elizabeth Larocque, Elizabeth T. Chang, Brandon A. Carter-Cooper, Modi Wang, Sandra E. Torregrossa-Allen, Bennett D. Elzey, Rena G. Lapidus, Herman Sintim

Department of Chemistry Faculty Publications

B

ackground: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is about 30% and for elderly patients, the rate drops to b10%. About 30% of AML patients harbor an activating mutation in the tyrosine kinase domain (TKD) of Fms-Like Tyrosine kinase 3 (FLT3) or a FLT3 internal tandem duplication (FLT3-ITD). In- hibitors of FLT3, such as Rydapt that was recently approved by the FDA, have shown good initial response but pa- tients often relapse due to secondary mutations in the …

Datasets On The Genomic Positions Of The Mll1 Morphemes, The Zfp57 Binding Site, And Zfbs-Morph Overlaps In The Build Mm9 Of The Mouse Genome, Minou Bina, Phillip Wyss, Xiaohui C. Song

Department of Chemistry Faculty Publications

While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs. This report provides tables listing the nucleotide sequences of the MLL1 morphemes and ZFBS-Morph overlaps. The report also offers links to the …