Physical Sciences and Mathematics Commons^™

Direct Patterning Of Silanized-Biomolecules On Semiconductor Surfaces, Dorjderem Nyamjav, Richard C. Holz

Chemistry Faculty Research and Publications

A novel approach to pattern silanized-biomolecules directly onto glass (SiO_x) substrates via Dip-Pen nanolithography (DPN) and microcontact printing (μCP) is presented. Subsequent hybridization reactions of DPN patterned silanized-DNA with its complementary strands provide “proof-of-concept” that the patterned oligonucleotides maintain their biological activities. The fabrication strategy does not require premodification of substrates and offers a cheap and robust way to immobilize molecules on electronically important semiconductor surfaces.

Study On Intumescent Flame Retarded Polystyrene Composites With Improved Flame Retardancy, Hongdian Lu, Charles A. Wilkie

Chemistry Faculty Research and Publications

The flame retardancy and thermal stability of ammonium polyphosphate/tripentaerythritol (APP/TPE) intumescent flame retarded polystyrene composites (PS/IFR) combined with organically-modified layered inorganic materials (montmorillonite clay and zirconium phosphate), nanofiber (multiwall carbon nanotubs), nanoparticle (Fe₂O₃) and nickel catalyst were evaluated by cone calorimetry, microscale combustion calorimetry (MCC) and thermogravimetric analysis (TGA). Cone calorimetry revealed that a small substitution of IFR by most of these fillers (≤2%) imparted substantial improvement in flammability performance. The montmorillonite clay exhibited the highest efficiency in reducing the peak heat release rate of PS/IFR composite, while zirconium phosphate modified with C₂₁H_{26 …}

Low Temperature Photo-Oxidation Of Chloroperoxidase Compound Ii, Xinting Yuan, Xin Sheng, John A. Horner, Brian Bennett, Leslie W. -M. Fung, Martin Newcomb

Physics Faculty Research and Publications

Oxidation of the heme-thiolate enzyme chloroperoxidase (CPO) from Caldariomyces fumago with peroxynitrite (PN) gave the Compound II intermediate, which was photo-oxidized with 365 nm light to give a reactive oxidizing species. Cryo-solvents at pH ≈ 6 were employed, and reactions were conducted at temperatures as low as − 50 °C. The activity of CPO as evaluated by the chlorodimedone assay was unaltered by treatment with PN or by production of the oxidizing transient and subsequent reaction with styrene. EPR spectra at 77 K gave the amount of ferric protein at each stage in the reaction sequence. The PN oxidation step …

On Semigroups With Lower Semimodular Lattice Of Subsemigroups, Peter R. Jones

Mathematics, Statistics and Computer Science Faculty Research and Publications

The question of which semigroups have lower semimodular lattice of subsemigroups has been open since the early 1960s, when the corresponding question was answered for modularity and for upper semimodularity. We provide a characterization of such semigroups in the language of principal factors. Since it is easily seen (and has long been known) that semigroups for which Green's relation J is trivial have this property, a description in such terms is natural. In the case of periodic semigroups—a case that turns out to include all eventually regular semigroups—the characterization becomes quite explicit and yields interesting consequences. In the general case, …

Powerpack: Energy Profiling And Analysis Of High-Performance Systems And Applications, Rong Ge, Xizhou Feng, Shuaiwen Song, Hung-Ching Chang, Dong Li, Kirk W. Cameron

Mathematics, Statistics and Computer Science Faculty Research and Publications

Energy efficiency is a major concern in modern high-performance computing system design. In the past few years, there has been mounting evidence that power usage limits system scale and computing density, and thus, ultimately system performance. However, despite the impact of power and energy on the computer systems community, few studies provide insight to where and how power is consumed on high-performance systems and applications. In previous work, we designed a framework called PowerPack that was the first tool to isolate the power consumption of devices including disks, memory, NICs, and processors in a high-performance cluster and correlate these measurements …

Chelate-Assisted Oxidative Coupling Reaction Of Arylamides And Unactivated Alkenes: Mechanistic Evidence For Vinyl C–H Bond Activation Promoted By An Electrophilic Ruthenium-Hydride Catalyst, Ki Hyeok Kwon, Do W. Lee, Chae S. Yi

Chemistry Faculty Research and Publications

The cationic ruthenium hydride complex [(η⁶-C₆H₆)(PCy₃)(CO)RuH]⁺BF₄⁻ was found to be a highly regioselective catalyst for the oxidative C−H coupling reaction of aryl-substituted amides and unactivated alkenes to give o-alkenylamide products. The kinetic and spectroscopic analyses support a mechanism involving a rapid vinyl C−H activation followed by a rate-limiting C−C bond formation step.

Non-Invasive Prenatal Detection Of Trisomy 21 Using Tandem Single Nucleotide Polymorphisms, Sujana Ghanta, Michael Mitchell, Mary Ames, Mats Hidestrand, Pippa Simpson, Mary Goetsch, William Thilly, Craig Struble, Aoy Tomita-Mitchell

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background: Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the majority of pregnant women. However, current tests rely on either evaluating non-specific markers, which lead to false negative and false positive results, or on invasive tests, which while highly accurate, are expensive and carry a risk of fetal loss. We outline a novel, rapid, highly sensitive, and targeted approach to non-invasively detect fetal T21 using maternal plasma DNA.

Methods and Findings: Highly heterozygous tandem Single Nucleotide Polymorphism (SNP) sequences on chromosome 21 were analyzed using High-Fidelity PCR and Cycling Temperature Capillary …

Improved Magnetic Domain-Wall Control With Transverse Fields, Andrew Kunz

Physics Faculty Research and Publications

No abstract provided.

Controlling Individual Domain Walls In Ferromagnetic Nanowires For Memory And Sensor Applications, Andrew Kunz, Sarah C. Reiff, Jonathan D. Priem, Eric W. Rentsch

Physics Faculty Research and Publications

Controlled motion of 180o and 360o domain walls along planar nanowires is presented. Standard Landau – Lifshitz micromagnetic modeling has been used to simulate the response of the domain walls to the application of an external magnetic field. A 180o wall is quickly and easily moved with the application of an applied. field along the axis of the wire but a 360odomain wall is stationary in the same case. An oscillatory applied field can be used to continually move the wall along the wires axis. The speed at which the 360o domain wall is found to be several times slower …

Converting Glx2-1 Into An Active Glyoxalase Ii, Pattraranee Limphong, Nicole E. Adams, Matthew F. Rouhier, Ross M. Mckinney, Melissa Naylor, Brian Bennett, Christopher A. Makaroff, Michael W. Crowder

Physics Faculty Research and Publications

Arabidopsis thaliana glyoxalase 2-1 (GLX2-1) exhibits extensive sequence similarity with GLX2 enzymes but is catalytically inactive with SLG, the GLX2 substrate. In an effort to identify residues essential for GLX2 activity, amino acid residues were altered at positions 219, 246, 248, 325, and 328 in GLX2-1 to be the same as those in catalytically active human GLX2. The resulting enzymes were overexpressed, purified, and characterized using metal analyses, fluorescence spectroscopy, and steady-state kinetics to evaluate how these residues affect metal binding, structure, and catalysis. The R246H/N248Y double mutant exhibited low level S-lactoylglutathione hydrolase activity, while the R246H/N248Y/Q325R/R328K mutant exhibited …

Quantitative Analysis Of Arterial Spin Labeling Fmri Data Using A General Linear Model, Luis Hernandez-Garcia, Hesamoddin Jahanian, Daniel Rowe

Mathematics, Statistics and Computer Science Faculty Research and Publications

Arterial spin labeling techniques can yield quantitative measures of perfusion by fitting a kinetic model to difference images (tagged-control). Because of the noisy nature of the difference images investigators typically average a large number of tagged versus control difference measurements over long periods of time. This averaging requires that the perfusion signal be at a steady state and not at the transitions between active and baseline states in order to quantitatively estimate activation induced perfusion. This can be an impediment for functional magnetic resonance imaging task experiments. In this work, we introduce a general linear model (GLM) that specifies Blood …

A Methodology For Engineering Collaborative And Ad-Hoc Mobile Applications Using Syd Middleware, Praveen Madiraju, Srilaxmi Malladi, Janaka Balasooriya, Arthi Hariharan, Sushil K. Prasad, Anu Bourgeois

Mathematics, Statistics and Computer Science Faculty Research and Publications

Today’s web applications are more collaborative and utilize standard and ubiquitous Internet protocols. We have earlier developed System on Mobile Devices (SyD) middleware to rapidly develop and deploy collaborative applications over heterogeneous and possibly mobile devices hosting web objects. In this paper, we present the software engineering methodology for developing SyD-enabled web applications and illustrate it through a case study on two representative applications: (i) a calendar of meeting application, which is a collaborative application and (ii) a travel application which is an ad-hoc collaborative application. SyD-enabled web objects allow us to create a collaborative application rapidly with limited coding …

Processing Induced Voxel Correlation In Sense Fmri Via The Ammust Framework, Daniel Rowe, Iain P. Bruce

Mathematics, Statistics and Computer Science Faculty Research and Publications

No abstract provided.

A Class Of Models For Uncorrelated Random Variables, Nader Ebrahimi, Gholamhossein Hamedani, Ehsan S. Soofi, Hans Volkmer

Mathematics, Statistics and Computer Science Faculty Research and Publications

We consider the class of multivariate distributions that gives the distribution of the sum of uncorrelated random variables by the product of their marginal distributions. This class is defined by a representation of the assumption of sub-independence, formulated previously in terms of the characteristic function and convolution, as a weaker assumption than independence for derivation of the distribution of the sum of random variables. The new representation is in terms of stochastic equivalence and the class of distributions is referred to as the summable uncorrelated marginals (SUM) distributions. The SUM distributions can be used as models for the joint distribution …

The Utility Of Nanocomposites In Fire Retardancy, Linjiang Wang, Xuejun He, Charles A. Wilkie

Chemistry Faculty Research and Publications

Nanocomposites have been shown to significantly reduce the peak heat release rate, as measured by cone calorimetry, for many polymers but they typically have no effect on the oxygen index or the UL-94 classification. In this review, we will cover what is known about the processes by which nanocomposite formation may bring this about. Montmorillonite will be the focus in this paper but attention will also be devoted to other materials, including carbon nanotubes and layered double hydroxides. A second section will be devoted to combinations of nanocomposite formation with conventional (and unconventional) fire retardants. The paper will conclude with …

The Effect Of Boron-Containing Layered Hydroxy Salt (Lhs) On The Thermal Stability And Degradation Kinetics Of Poly (Methyl Methacrylate), Stephen Majoni, Shengpei Su, Jeanne Hossenlopp

Chemistry Faculty Research and Publications

A boron-containing layered hydroxy salt (LHS), ZHTMDBB, was prepared and compounded with a highly flammable synthetic polymer, poly (methyl methacrylate) {PMMA}, via melt blending: the composite structure was intercalated with poor dispersion. The effect of this LHS on the flammability, thermal stability and degradation kinetics of PMMA was investigated via cone calorimetry and thermogravimetric analysis. The addition of 3-10% by mass of ZHTMDBB to PMMA resulted in significant reduction of peak heat release rate (22-48%) of the polymer and improvements in thermal stability were observed in both air and nitrogen. Effective activation energies for the degradation process were evaluated using …

Chain-Selective And Regioselective Ethylene And Styrene Dimerization Reactions Catalyzed By A Well-Defined Cationic Ruthenium-Hydride Complex: New Insights On The Styrene Dimerization Mechanism, Do W. Lee, Chae S. Yi

Chemistry Faculty Research and Publications

The cationic ruthenium hydride complex [(η⁶-C₆H₆)(PCy₃)(CO)RuH]⁺BF₄⁻ was found to be a highly regioselective catalyst for the ethylene dimerization reaction to give 2-butene products (TOF = 1910 h⁻¹, >95% selectivity for 2-butenes). The dimerization of styrene exclusively produced the head-to-tail dimer (E)-PhCH(CH₃)CH═CHPh at an initial turnover rate of 2300 h⁻¹. A rapid and extensive H/D exchange between the vinyl hydrogens of styrene-d₈ and 4-methoxystyrene was observed within 10 min without forming the dimer products at room temperature. The inverse …

Noise Assumptions In Complex-Valued Sense Mr Image Reconstruction, Daniel B. Rowe, Iain P. Bruce

Mathematics, Statistics and Computer Science Faculty Research and Publications

In fMRI, brain images are not measured instantaneously and a volume of images can take two seconds to acquire at a low 64x64 resolution. Significant effort has been put forth on many fronts to decrease image acquisition time including parallel imaging. In parallel imaging, sub-sampled spatial frequency points are measured in parallel and combined to form a single image. Measurement time is decreased at the expense of increased image reconstruction difficulty and time. One significant parallel imaging technique known as SENSE utilizes a complex-valued regression coefficient estimation process with transposes replaced by conjugate transposes. However, in SENSE the noise structure …

A Formal Context Specific Trust Model (Ftm) For Multimedia And Ubiquitous Computing Environment, Sheikh Iqbal Ahamed, Munirul M. Haque, Nilothpal Talukder

Mathematics, Statistics and Computer Science Faculty Research and Publications

In order to ensure secure sharing of resources in an ad-hoc network of handheld devices in a multimedia and ubiquitous computing environment, mutual collaboration is essential. However, the limitations, such as poor storage and computational capability of these multimedia and ubiquitous devices stand as the bottleneck for effective sharing of resources. As a result of this drawback, the adversaries are obtaining access to the new doors for security breaches. Mutual Trust is the weapon used to combat security violations by restricting malicious devices from participating in any interaction in such an open and dynamic environment. In this paper, we present …

Injecting, Controlling, And Storing Magnetic Domain Walls In Ferromagnetic Nanowires, Andrew Kunz, Jonathan D. Priem, Sarah C. Reiff

Physics Faculty Research and Publications

Domain walls in ferromagnetic nanowires are important for proposed devices in recording, logic, and sensing. The realization of such devices depends in part on the ability to quickly and accurately control the domain wall from creation until placement. Using micromagnetic computer simulation we demonstrate how a combination of externally applied magnetic fields is used to quickly inject, move, and accurately place multiple domain walls within a single wire for potential recording and logical operations. The use of a magnetic field component applied perpendicular to the principle domain wall driving field is found to be critical for increased speed and reliability. …

Acm/Springer Mobile Networks And Applications (Monet) Special Issue On “Advanced Mobile Applications And Intelligent Multimedia Systems For Ubi-Com”, Jong Hyuk Park, Shu-Ching Chen, Mieso Denko, Sheikh Iqbal Ahamed

Mathematics, Statistics and Computer Science Faculty Research and Publications

No abstract provided.

X-Ray Structure Of Mer-[Mo(Co)3(Pph3)(Κ2-Dppm)], Shishir Ghosh, Shariff E. Kabir, Faranza K. Camellia, Md. Kamal Hossain, Daniel T. Haworth, Sergey V. Lindeman, Tasneem A. Siddiquee, Dennis W. Bennett

Chemistry Faculty Research and Publications

Treatment of [Mo(CO)₃(NCMe)₃] with bis(diphenylphosphino)methane (dppm) and triphenylphosphine (PPh₃) at 50 °C afforded mer-[Mo(CO)₃(PPh₃)(κ²-dppm)] (1) in 55% yield which has been characterized by single crystal X-ray diffraction studies and spectroscopic measurements. Compound 1 crystallizes in the triclinic space group P−1 with a = 10.3449(6), b = 11.1570(6), c = 17.8961(10) Å, β = 80.8400(10)°, Z = 2 and V = 1959.8(2) ų.

Fastmedusa: A Parallelized Tool To Infer Gene Regulatory Networks, Serdar Bozdag, Aiguo Li, Stefan Wuchty, Howard A. Fine

Mathematics, Statistics and Computer Science Faculty Research and Publications

Motivation: In order to construct gene regulatory networks of higher organisms from gene expression and promoter sequence data efficiently, we developed FastMEDUSA. In this parallelized version of the regulatory network-modeling tool MEDUSA, expression and sequence data are shared among a user-defined number of processors on a single multi-core machine or cluster. Our results show that FastMEDUSA allows a more efficient utilization of computational resources. While the determination of a regulatory network of brain tumor in Homo sapiens takes 12 days with MEDUSA, FastMEDUSA obtained the same results in 6 h by utilizing 100 processors. Availability: Source code and documentation of …

De Novo Synthesis Of Polyhydroxyl Aminocyclohexanes, Anobick Sar, Sergey Lindeman, William Donaldson

Chemistry Faculty Research and Publications

The syntheses of 12 stereochemically diverse polyhydroxyl aminocyclohexane (“aminocyclitols”) derivatives are described. These short syntheses require 2–5 steps from N-(2,4-cyclohexadien-1-yl)phthalimide, which is prepared in two steps from tricarbonyl(cyclohexadienyl)iron(1+). The relative stereochemistries of the aminocyclitols were assigned by ¹H NMR spectroscopy as well as X-ray diffraction analysis.

Dynamic Notch Pinning Fields For Domain Walls In Ferromagnetic Nanowires, Andrew Kunz, Jonathan D. Priem

Physics Faculty Research and Publications

Artificial defects such as notches and antinotches are often attached to magnetic nanowires to serve as trapping (pinning) sites for domain walls. The magnetic field necessary to release (depin) the trapped domain wall from the notch depends on the type, geometric shape, and dimensions of the defect but is typically quite large. Conversely we show here that for some notches and antinotches there exists a much smaller driving field for which a moving domain wall will travel past the defect without becoming trapped. This dynamic pinning field also depends on the type, geometric shape and defect dimensions. Micromagnetic simulation is …

Simulations Of Field Driven Domain Wall Interactions In Ferromagnetic Nanowires, Andrew Kunz, Eric W. Rentsch

Physics Faculty Research and Publications

The interaction of domain walls in a single ferromagnetic nanowire has been observed with micromagnetic simulation. Domain walls separating domains of opposite magnetization move towards each other when an external field is applied along the long axis of the wire resulting in a collision. The final magnetic state of the wire after the collision will contain either zero (domain wall annihilation) or two (domain wall conservation) domain walls. Here we explore the behavior that determines the final state, showing that it depends on the initial domain wall configuration, the speed the domain walls are moving with before the collision, and …

Magnetic Response Versus Lift Height Of Thin Ferromagnetic Films, Tanner Schulz, Gabe Burch, Andrew Kunz, E. Dan Dahlberg

Physics Faculty Research and Publications

The interaction between a magnetic force microscope (MFM) tip and ferromagnetic films of Ni, Co₉₀Fe₁₀ and Py with in-plane magnetization has been investigated. The measured interaction, due to the magnetizing of the films by the MFM tip field, was determined by the phase shift of the cantilever response. The tip-film separation or lift height dependent phase shift was found to be independent of the saturation magnetization of the ferromagnetic film. The result is identical for all three films and micromagnetic simulations give similar results. The reason is at a given tip-sample separation the tip induced magnetization of …

The Teaching Of Equation Solving: Approaches In Standards-Based And Traditional Curricula In The United States, Jinfa Cai, Bikai Nie, John Moyer

Mathematics, Statistics and Computer Science Faculty Research and Publications

This paper discusses the approaches to teaching linear equation solving that are embedded in a Standards-based mathematics curriculum (Connected Mathematics Program or CMP) and in a traditional mathematics curriculum (Glencoe Mathematics) in the United States. Overall, the CMP curriculum takes a functional approach to teaching equation solving, while Glencoe Mathematics takes a structural approach. The functional approach emphasizes the important ideas of change and variation in situations and contexts. It also emphasizes the representation of relationships between variables. The structural approach, on the other hand, requires students to work abstractly with symbols and follow procedures in a systematic way. …

Regioselective Formation Of Α-Vinylpyrroles From The Ruthenium-Catalyzed Coupling Reaction Of Pyrroles And Terminal Alkynes Involving C–H Bond Activation, Ruili Gao, Chae S. Yi

Chemistry Faculty Research and Publications

The cationic ruthenium catalyst Ru₃(CO)₁₂/NH₄PF₆ was found to be highly effective for the intermolecular coupling reaction of pyrroles and terminal alkynes to give gem-selective α-vinylpyrroles. The carbon isotope effect on the α-pyrrole carbon and the Hammett correlation from a series of para-substituted N-arylpyrroles (ρ = −0.90) indicate a rate-limiting C−C bond formation step of the coupling reaction.

Time Series Models For Computing Activation In Fmri, Daniel W. Adrian, Ranjan Maitra, Daniel B. Rowe

Mathematics, Statistics and Computer Science Faculty Research and Publications

No abstract provided.