Physical Sciences and Mathematics Commons^™

Rede Neural Para A Predição De Óbito Utilizando Biomarcadores De Pacientes Em Hemodiálise No Sistema Único De Saúde., Isadora Badalotti-Teloken

AMNET XX Conferencia Internacional

No abstract provided.

Produção De Artigos Científicos No Estudo Longitudinal De Saúde Do Adulto (Elsa-Brasil), 2011-2023, Arthur Sandi Bauermann, Maria Antônia Mylius De Oliveira, Clara Akemi Basso Aseka, Luiza Dalmolin Beneduzi

AMNET XX Conferencia Internacional

No abstract provided.

Investigating The Structural Complexity Of The Uch Knot Protein Using Trapped Ion Mobility Spectrometry – Mass Spectrometry, Shirley Hernandez

Undergraduate Research at FIU (URFIU) Conference

Knot proteins are rare proteins whose backbones adopt knotted configurations with a wide range of topologically interesting features [Lim, 2015]. They were regarded as structural impossibilities, until they were observed embedded in naturally-occurring proteins in the early 2000s [Taylor, 2000; Lim, 2003]. Ubiquitin carboxyl-terminal hydrolase, or UCH, is one of the most complex knot proteins studied to-date. UCH contains a knot structure composed of 5 crossings around the polypeptide chain (52 knot). Humans have four UCHs: UCH-L1, UCH-L3, UCH-L5 and BAP1. The UCH-L1 in particular is found in abundance in the nerve cells of the brain and is thought to …

Effects Of Flooding And Soil- Applied Solid Oxygen Fertilizers On Physiology And Growth Of Papaya Plants, Stephanie Torres

Undergraduate Research at FIU (URFIU) Conference

Papaya is grown exclusively in South Florida. Over ninety percent of the papaya production is in Miami-Dade County. The remaining acreage is primarily located in counties adjacent to Miami-Dade County. Average yield can approach 25,000 pounds per acre. With a pack-out of 85 percent and a price of $0.30 per pound, income from an acre of papaya would have been worth approximately $6,375. Papaya thrives under warm conditions with abundant rainfall or irrigation. It cannot tolerate strong winds, flooding, or frosts, and it recuperates very slowly if it has sustained considerable leaf or root injury. Soils should be well drained, …

Accessibility Of The Heme-Pocket In Hexa-Coordinate Globins, Maria Jose Santiago

Undergraduate Research at FIU (URFIU) Conference

Studies of fluorescence analogues of neuroglobin and cytoglobin to characterize conformational changes upon ligand binding Neuroglobin (Ngb) and cytoglobin (Cygb) are newly discovered hexacoordinate members of the globin family. Ngb is expressed in nerve cells and the retina and its main role is to protect cells under hypoxic–ischemic conditions. Cygb is expressed almost in all tissues in our body and it have tumor suppression role. Here we report a preparation of fluorescent analogues of Ngb and Cygb by replacing the non-fluorescent Fe protoporphyrin IX with a fluorescent probe, Zn protoporphyrin IX (ZnPPIX). The accessibility of the heme binding pocket in …

Ionospheric Behavior During Ascendant Phase Of Solar Cycle 21, Jenesis Escobar

Undergraduate Research at FIU (URFIU) Conference

This study describes the behavior of the peak value of the ionospheric concentration (foF2) during the ascending phase of Solar Cycle 21. In order to understand the ionospheric dependency with the solar activity during the ascending phase of solar cycle 21 (1976 to 1981), peak ionospheric values for multiple ionospheric stations have been downloaded from the National Oceanic and atmospheric Administration (NOAA)’s National Geophysics Data Center (NGDC) database and analyzed using a new approach: The study of daily maximum and minimum values. Many interesting characteristics of the ionospheric behavior were detected, while the trend of the maxima closely follows the …

How Middle School Boys From Underrepresented Communities Perceive Computer Science And Computer Science Careers, Cristal Kelly

Undergraduate Research at FIU (URFIU) Conference

Computer science (CS) as a field is characterized by significant disparities in the representation of people groups from minority populations. In this phenomenological study we sought to understand how middle school boys from minority groups perceive CS and related careers with the goal of identifying the factors that contribute to their career intentions. Specifically we sought to answer the following questions: How are salient factors reported by middle school boys related to CS career aspirations associated with their cultural values? How do perceived barriers shape their career intentions? And how do high CS interest and negative perceptions interact to affect …

Novel Synthesis Of The Homologs Of Natural Nucleosides, Erika Lozano

Undergraduate Research at FIU (URFIU) Conference

Homologated nucleoside analogs are frequently studied for their antiviral activity. They are effective for the treatment of infectious species like the herpes virus, varicella-zoster viruses and retroviruses like HIV (Human Immunodeficiency Virus). Successful synthesis of these organic compounds has been achieved in the past through the transformation of the alcohol functionality into a carbonyl, often followed by Wittig reaction or Ardnt-Eistert homologation. Additionally, others have generated the homologated sugar moiety and then proceeded with the coupling to nucleobases. Researchers from Palacky University recently developed novel methodology for the homologation of primary and secondary alcohols. They generated the homologated esters of …

Synthesis Of (E)-2- Chlorhomovinyl Ribose To Examine The Mechanism Of 6-Chlorhomovinyl Adenosine, Mattew Pasteris

Undergraduate Research at FIU (URFIU) Conference

Nucleosides function as important agents in fundamental human metabolism and provide a broad range of activity in resulting modification of these nucleosides as functional prodrugs. Various modified nucleosides exhibit inhibitory activity towards enzymes and carry the possibility of containing anti-viral and anti-cancer properties. These properties are often exhibited by modifying the nucleobase moiety or the sugar moiety as synthesized novel nucleosides. In understanding my project aim, the sugar moiety of 6-chlorohomovinyl adenosine will be synthesized as the novel nucleoside (E)-2-chlorovinylribose to examine the nucleoside as the active component of 6-chlorohomovinyl adenosine. 6-chlorohomovinyl adenosine 1 demonstrates an active component …

Ionospheric Behavior During Descendant Phase Of Solar Cycle 20, Victor Payen

Undergraduate Research at FIU (URFIU) Conference

This study describes the behavior of the peak value of the ionospheric concentration (foF2) during the descending phase of Solar Cycle 20. In order to understand the ionospheric dependency with the solar activity during the descending phase of solar cycle 20 (1970 to 1975), peak ionospheric values for multiple ionospheric stations have been downloaded from the National Oceanic and atmospheric Administration (NOAA)’s National Geophysics Data Center (NGDC) database and analyzed using a new approach: The study of daily maximum and minimum values. Many interesting characteristics of the ionospheric behavior were detected, while the trend of the maxima closely follows the …

Synthesis, Structure And Properties Of Two Symmetrical Oxorhenium(V) Dimers Derived From 4-Chloro Pyrazole, Juliana Cazzaniga

Undergraduate Research at FIU (URFIU) Conference

Oxorhenium(V) complexes are of considerable interest due to their multifaceted applications in the field of catalysis and in radiopharmaceuticals. The properties of these oxo-complexes can be “finetuned” through appropriate ligand choices. Our lab has been engaged in the development of coordination chemistry with pyrazoles due to their versatile binding modes. Pyrazole can bind a metal center in either monodentate or bridging bidentate fashion. Moreover, the 3, 4, and 5- positions on pyrazole ring offer the opportunity for suitable functionalization for desired applications. Although there has been a plethora of research work on transition metal coordination complexes involving pyrazole(s), there is …

The Application Of Ion Mobility Spectrometry And Ultrahigh Resolution Spectrometry For Analysis Of Anti- Microbial Peptides From Frog Skin Secretions, Benjamin Bokor

Undergraduate Research at FIU (URFIU) Conference

Frog skin secretions of antimicrobial peptides (AMPs) are of increasing interest due to the protection they impart against microbes. Such peptides offer the prospect of new and efficient sources of bacterial, fungal, and viral treatments. Recently, an epizootic of chytridiomycosis from the fungal pathogen Batrachochytrium dendrobatidis (Bd) caused the death of many amphibian species in the Andes. However, certain species of frogs such as Hypsiboas gladiator were able to survive. It is speculated that the survival of Hypsiboas gladiator is due to AMPs secreted from their skin.

The identification and characterization of these peptides is necessary for understanding the antimicrobial …

Putting The Generic Solution Of Transparent Thinking Approach (Tta) In Instructional Material Production, Mohammad A. Aliedeh, Sajedah Aliedeh

ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens

Humanity is overburdened by an overwhelming challenges, problems and failures that are plaguing global development system, in general, and global educational system in specific. Transparent Thinking Approach (TTA) is developed in response to these multi scale and multi domain problems by offering a generic reform approach that enable the thinker to employ a multi perspective, maneuvering, and modeling tools while looking for a solution. TTA is a newly developed value-engrained and thinking based educational reform approach. It is generic and unique features enables it to easily diffuse in all domains (Aliedeh, M. A., 2015 a, b, c, 2016, …

Questioning - Fundamental 21st Century Comptence, Teresa Lucas, Gerardo Lucas

ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens

With the advent of the 21^st Century, scholars, politicians, scientists, educators, entrepreneurs, religious leaders, and parents have looked at the increasing rapidity of change and complexity in the world, and wondered what capabilities are necessary to embrace the challenges facing us. The P21 Partnership cites four basic “C” skills: creativity and innovation; critical thinking and problem-solving; communication; and, collaboration. However, developing the “4 Cs” relies on another attribute – curiosity, the hallmark of which is the ability to formulate good questions. This workshop proposes to engage participants in a lively exercise of asking questions. A brief introduction reviews various …

Educando Hacia La Sustentabilidad, Maria F. Guida

ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens

Las escuelas y los sistemas educativos fueron creados para responder a los desafíos emergentes de un determinado período histórico. A medida que avanzamos en la historia de la educación observamos que se utilizaron distintos modelos según los factores políticos y socioeconómicos del momento.

El modelo actual de la escuela todavía responde a inquietudes del siglo pasado. Nuestro mundo atraviesa realidades totalmente distintas y nuestro futuro es cambiante y desconocido.

Problemáticas mundiales como el Calentamiento Global y Cambio Climático constituyen grandes ejemplos de esta nueva etapa que atraviesa nuestro planeta. Debemos preparar a nuestros alumnos a manejarse ante estos continuos cambios …

Self-Coaching With Ai: Developing Thinking Skills, Thinking Dispositions, And Well-Being, Olivier Malafronte, Isla Reddin, Roy Van Den Brink-Budgen

ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens

Being motivated by the need to address the challenges of our Volatile Uncertain Complex Ambiguous world, we strive to create tools to improve people’s lives and help them become more resilient, resourceful, self-confidant, and successful.

In a digital world, we must understand how to efficiently connect to digital systems. Connecting “with AI” doesn’t mean spending more time on digital devices, but spending time in a deliberate way with purpose and intentional learning outcomes.

As a society, we want to see graduates with emotional intelligence and reflective skills in order to address global economic and social issues. As for jobs …

Trash To Treasure, Kim Rizio, Brooke Fatima Yubero, Defne Timurkan, Corey Gildersleeve

ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens

Based on research of the “Children Are Citizens” initiative from Project Zero at Harvard University, the Trash to Treasure project will engage and capacitate our preschoolers and lower elementary students to be agents of change in our local community. This interdisciplinary project will bring attention to an important environmental issue within our community. Plastic pollution will be transformed into an interactive exhibit and lead our students from bystanders to advocates. Community-wide beach clean-ups will provide students with the trash to create an original multi-media piece that incorporates movement to engage and communicate our message. The installation of the piece in …

The Bioaccessibility Of Methylmercury In Rice And Fish, Michael Angelo Ojeda

Undergraduate Research at FIU (URFIU) Conference

Traditionally, fish is considered as the major source for humans exposed to methylmercury (MeHg), which is a highly toxic contaminant,-however recent study has shown that consumption of rice could be another MeHg exposure pathway to human beings. To evaluate the potential health risk caused by consumption of rice and rice product contraining MeHg, not only amount but also the bioaccessibility of MeHg in rice and rice products are required, because the amounts of methylmercury in samples is an overestimate and does not provide the accurate fraction that is mobilized from the food source. An in vitro digestive method was used …

Investigation Of The Hydrophobic Sites Of Dream, Daniel Rapado

Undergraduate Research at FIU (URFIU) Conference

DREAM (downstream regulatory element antagonist modulator) also known as calsenilin or KChIP-3 is a calcium binding protein that has been associated with memory retention, pain sensing, calcium homeostasis and Alzheimer’s disease. It has two EF hands that bind Ca2+ and change the conformation of the protein. DREAM has two hydrophobic cavities in both the N- and C- terminus. These hydrophobic sites act as important binding sites with Kv channels, presenilin and other small molecules. Previously our group has showed that hydrophobic molecules such as NS5806 and 1,8- ANS can bind to the hydrophobic cavities in the C-terminus. The aim of …

Targeting Transcription-Coupled Dna Supercoiling For Discovery Of Bacterial Dna Gyrase Inhibitors, Alex Capaldo

Undergraduate Research at FIU (URFIU) Conference

Antibiotic production has been stagnant in the recent decade in comparison to the 30-years before that. The emergence of multidrug resistant bacteria is of mounting importance and a universal problem. The stagnation of antibiotic production, in part, is due to the lack of innovation in creating highly specific screening tools. Bacterial DNA gyrase is a type II topoisomerase that introduces negative supercoils into DNA, an essential mechanism for bacteria but absent from eukaryotes, making it an ideal target for identifying antibacterial compounds. In this study, we have constructed an E. coli strain FL#1181 that contains a pair of divergently coupled …

Crude Oil Characterization Using Sara Fractionation And Gc-Ms, Nicholas Hernandez

Undergraduate Research at FIU (URFIU) Conference

Crude oil is a naturally-occurring liquid mixture, composed of hydrocarbons as well as oxygen, nitrogen and sulfur-containing compounds. While previous research has been able to identify broad differences between classes of crude oil, the elucidating the structure of compounds within oils remains elusive, especially for heavier compounds. To determine the composition of Boscan, a heavy crude oil, SARA fractionation was performed to separate the sample into 4 different classes of chemical compounds: saturated hydrocarbons, aromatic compounds, resins, and asphaltenes. A sample of oil was chromatographically separated on activated alumina using solvents of increasing polarity. Each fraction was analyzed using gas …

Break Junction Technique For Studying Individual Biological Molecules, Brian Mayorga

Undergraduate Research at FIU (URFIU) Conference

Single molecule biophysics is a rapidly growing field that has great implications in the broader area of nanotechnology. The quantum properties of complex biological molecules can also be studied through the use of advanced techniques that examine molecules on an individual scale. Current methods for studying individual molecules often lack the accuracy needed to yield satisfactory data. In our experiments, we attempted to use a Scanning Tunneling Microscope (STM) based break junction method to study the quantum tunneling current through small biomolecules. By probing the currents changes through these molecules on an individual scale under external gating and in a …

Surface-Enhanced Raman Spectroscopy Study Of Arsenic Speciation Under Cellular Matrix Influence, Mingwie Yang, Afia Anjuman

Undergraduate Research at FIU (URFIU) Conference

Arsenic is an environmentally consequential metalloid which has various species based on its oxidation states and methyl substituents. In this study, Surface-Enhanced Raman Spectroscopy was utilized to explore Arsenic speciation under the cellular matrix influence using physiological buffers (sodium bicarbonate, phosphate etc.). Four common existing arsenicals were used: arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid. Liquid droplets of arsenical solutions were dropped onto the Silver nanoparticle coated films and strong signals were generated by Raman spectroscopy. Signals were regenerated for the dried droplets after water evaporated from the solutions. Arsenicals were closer to the surface of the films and in …

Molecular Modeling Of Conformational Space Of The Knot Protein Yibk, Daniel Gimeno

Undergraduate Research at FIU (URFIU) Conference

Structurally, proteins follow entropy favorable layouts that have high stability while performing their function. Knots are typically not observed due the amount of energy needed to form this structure outweighed the stability of the protein. Despite this, there are several rare proteins whose polypeptide backbone form knotted configurations. YibK is one such protein with a trefoil knot (e.g., 3-1 knot) in its carboxy terminus. These proteins reveal interesting topographies with less entropy than if the protein were compressed. In the present work, we studied the main interactions involved in the folding pathway of YibK, based on molecular dynamics (MD) simulations …

The Effect Of Muscle Cell Differentiation On Ire1a Activation And The Unfolded Protein Response, Marco Zamora Bulla

Undergraduate Research at FIU (URFIU) Conference

The endoplasmic reticulum (ER), one of the base structures of a cell, is the site in which newly synthesized proteins are folded. This process is tightly regulated to ensure that the cell is working at optimal capacity and homeostasis, balance, is maintained. When the folding capacity of new proteins is surpassed, cells enter a state of stress called endoplasmic reticular stress (ER stress), which triggers the Unfolded Protein Response (UPR). The UPR is regulated by three main proteins inositol requiring enzyme 1 α (IRE1α), protein kinase RNA-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF 6), providing different …

Software Assisted Molecular Elucidation Based On Timsft- Icr Ms/Ms Analysis Of Complex Mixtures, Carlos Acosta

Undergraduate Research at FIU (URFIU) Conference

The determination of the chemical structure of a molecule within a complex mixture is a challenging analytical problem. In the present work, we describe a workflow based on the analytical characterization of complex mixtures using complementary Trapped Ion Mobility Separation and ultra-high resolution FT-ICR mass separation (TIMS-FT-ICR MS/MS) for the analysis of complex mixtures (e.g., crude oils and dissolved organic matter). In particular, we take advantage of the high mobility resolution and high mass accuracy of TIMS-FT-ICR MS/MS to generate candidate structures using a custom developed theoretical workflow for Software Assisted Molecular Elucidation (SAME) based on the ion-neutral collision cross …

Determination Of Effector Binding Affinities Using Pac, David Butcher, Jovany J. Betancourt

Undergraduate Research at FIU (URFIU) Conference

Determination of binding affinity and thermodynamic parameters of interactions between two molecules is a common procedure in biochemical contexts. Steady-state fluorescence titration is one of the most commonly used techniques to determine the binding affinity of small effector compounds and ligands to large biomolecules such as proteins. This method, however requires 1) the ligand to be fluorescent and exhibit a measureable change in fluorescence intensity between the bound and free states or 2) a fluorescent residue (e.g. tryptophan) near the ligand binding site whose fluorescence changes as a result of ligand binding. The new technique presented here utilizes photoacoustic calorimetry …

Terpene Adsorption Analysis In Tedlar Air Sampling Bags, Jeremy B. Guedes, Alison G. Simon

Undergraduate Research at FIU (URFIU) Conference

Tedlar® air sampling bags, which are composed of a polyvinyl fluoride polymer, are the EPA recommended bags used in several whole-air sampling and analytical methods for determining the presence of volatiles. Recent studies suggest that compounds which exhibit hydrogen bonding, as well as those that have a low vapor pressure, will tend to adsorb to the Tedlar® bags at a high rate. Furthermore, alkenes seem to display significant adsorption rates. For example, terpenes are a type of volatile organic compound (VOC) which contain the alkene functional group, and are found in oils produced by plants and some insects. In the …

Calculating Vsin(I) Of Planet-Hosting Young Stars, Jennifer Medina

Undergraduate Research at FIU (URFIU) Conference

Constraining the spin-orbit alignment of close-in planets in young systems can provide insight on their migratory history. We can combine Vsin(i) with measurements of the stellar rotation period and radius to determine the star's orbital inclination, which we can compare to that of the planet as determined from the transit. Vsin(i) is determined from the rotational broadening on the star's spectral lines, so it is ideal to work with young, fast-rotating stars where broadening is more easily measured. We measure Vsin(i) of seven planet-hosting stars within the Praesepe star cluster by using high-resolution spectra from the Immersion Grating INfrared Spectrometer …

Differences In Use Of Metaphor Between Narrative And Non-Narrative Texts, Armando J. Ochoa

Undergraduate Research at FIU (URFIU) Conference

Metaphors are widespread in human language and are used in all types of text. One of the most common text types are narratives, which share a number of unique structural traits which distinguish them from non-narrative types. We investigate if there is any difference in the use of metaphor between narrative and non-narrative texts. We first created a Java API to interface with the Vienna University Annotated Metaphor Corpus (VUAMC), which provides four different types of text (three non-narrative and one narrative) with word-by-word annotations of metaphor occurrences. We then contrasted narrative and non-narrative texts by calculating several similarity measures, …