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Dartmouth College

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2003

Articles 1 - 30 of 47

Full-Text Articles in Physical Sciences and Mathematics

Resonant Emergence Of Global And Local Spatiotemporal Order In A Nonlinear Field Model, Marcelo Gleiser, Rafael C. Howell Dec 2003

Resonant Emergence Of Global And Local Spatiotemporal Order In A Nonlinear Field Model, Marcelo Gleiser, Rafael C. Howell

Dartmouth Scholarship

We investigate the nonequilibrium evolution of a scalar field in (2+1) dimensions. The field is set in a double-well potential in contact (open) or not (closed) with a heat bath. For closed systems, we observe the synchronized emergence of coherent spatiotemporal configurations, identified with oscillons. This initial global ordering degenerates into localized order until all oscillons disappear. We show that the synchronization is driven by resonant parametric oscillations of the field’s zero mode and that local ordering is only possible outside equipartition. None of these orderings occur for open systems.

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Experimenting With Tcpa/Tcg Hardware, Or: How I Learned To Stop Worrying And Love The Bear, John Marchesini, Sean Smith, Omen Wild, Rich Macdonald Dec 2003

Experimenting With Tcpa/Tcg Hardware, Or: How I Learned To Stop Worrying And Love The Bear, John Marchesini, Sean Smith, Omen Wild, Rich Macdonald

Computer Science Technical Reports

Over the last few years, our group has been working on applications of secure coprocessors---but has been frustrated by the limited computational environment and high expense of such devices. Over the last few years, the TCPA (now TCG) has produced a specification for a trusted platform module (TPM)---a small hardware addition intended to improve the overall security of a larger machine (and tied up with a still-murky vision of Windows-based trusted computing). Some commodity desktops now come up with these TPMs. Consequently, we began an experiment to see if (in the absence of a Non-Disclosure Agreement) we could use this …

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A Subgroup Algorithm To Identify Cross-Rotation Peaks Consistent With Non-Crystallographic Symmetry, Ryan H. Lilien, Chris Bailey-Kellogg, Amy C. Anderson, Bruce R. Donald Dec 2003

A Subgroup Algorithm To Identify Cross-Rotation Peaks Consistent With Non-Crystallographic Symmetry, Ryan H. Lilien, Chris Bailey-Kellogg, Amy C. Anderson, Bruce R. Donald

Computer Science Technical Reports

Molecular replacement (MR) often plays a prominent role in determining initial phase angles for structure determination by X-ray crystallography. In this paper, an efficient quaternion-based algorithm is presented for analyzing peaks from a cross-rotation function to identify model orientations consistent with non-crystallographic symmetry (NCS), and to generate NCS-consistent orientations missing from the list of cross-rotation peaks. Our algorithm, CRANS, analyzes the rotation differences between each pair of cross-rotation peaks to identify finite subgroups of NCS. Sets of rotation differences satisfying the subgroup axioms correspond to orientations compatible with the correct NCS. The CRANS algorithm was first tested using cross-rotation peaks …

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Objectivity, Information, And Maxwell's Demon, Steven Weinstein Dec 2003

Objectivity, Information, And Maxwell's Demon, Steven Weinstein

Dartmouth Scholarship

This paper examines some common measures of complexity, structure, and information, with an eye toward understanding the extent to which complexity or information‐content may be regarded as objective properties of individual objects. A form of contextual objectivity is proposed which renders the measures objective, and which largely resolves the puzzle of Maxwell's Demon.

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Incommensurate Spin Density Waves In Iron Aluminides, D. R. Noakes, A. S. Arrott, M. G. Belk, S. C. Deevi Nov 2003

Incommensurate Spin Density Waves In Iron Aluminides, D. R. Noakes, A. S. Arrott, M. G. Belk, S. C. Deevi

Dartmouth Scholarship

Neutron diffraction in Fe(Al) reveals incommensurate spin density waves (SDWs) in alloys known to be spin glasses. The wave vectors for crystals of Fe(34Al), Fe(40Al), and Fe(43Al) show n varying from 11 to 6 for →q=2π(h±1/n,k±1/n,l±1/n)/a0, where (h,k,l) and a0 characterize the parent bcc lattice of the CsCl structure. The magnetic reflections are present far above the spin-glass freezing temperatures. These SDWs keep the spins on nearest-neighbor Fe atoms close to parallel, in contrast with SDWs in Cr, which keep nearest-neighbor spins close to antiparallel.

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Redshift-Distance Survey Of Early-Type Galaxies: Spectroscopic Data, G. Wegner, M. Bernardi, C. N. A. Willmer, L. N. Da Costa Nov 2003

Redshift-Distance Survey Of Early-Type Galaxies: Spectroscopic Data, G. Wegner, M. Bernardi, C. N. A. Willmer, L. N. Da Costa

Dartmouth Scholarship

We present central velocity dispersions and Mg2 line indices for an all-sky sample of ~1178 elliptical and S0 galaxies, of which 984 had no previous measures. This sample contains the largest set of homogeneous spectroscopic data for a uniform sample of elliptical galaxies in the nearby universe. These galaxies were observed as part of the ENEAR project, designed to study the peculiar motions and internal properties of the local early-type galaxies. Using 523 repeated observations of 317 galaxies obtained during different runs, the data are brought to a common zero point. These multiple observations, taken during the many runs …

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A Probability-Based Similarity Measure For Saupe Alignment Tensors With Applications To Residual Dipolar Couplings In Nmr Structural Biology, Anthony K. Yan, Christopher J. Langmead, Bruce Randall Donald Oct 2003

A Probability-Based Similarity Measure For Saupe Alignment Tensors With Applications To Residual Dipolar Couplings In Nmr Structural Biology, Anthony K. Yan, Christopher J. Langmead, Bruce Randall Donald

Computer Science Technical Reports

High-throughput NMR structural biology and NMR structural genomics pose a fascinating set of geometric challenges. A key bottleneck in NMR structural biology is the resonance assignment problem. We seek to accelerate protein NMR resonance assignment and structure determination by exploiting a priori structural information. In particular, a method known as Nuclear Vector Replacement (NVR) has been proposed as a method for solving the assignment problem given a priori structural information [24,25]. Among several different kinds of input data, NVR uses a particular type of NMR data known as residual dipolar couplings (RDCs). The basic physics of residual dipolar couplings tells …

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Stellar Pollution And [Fe/H] In The Hyades, Aaron Dotter, Brian Chaboyer Oct 2003

Stellar Pollution And [Fe/H] In The Hyades, Aaron Dotter, Brian Chaboyer

Dartmouth Scholarship

The Hyades open cluster presents a unique laboratory for planet formation and stellar pollution studies because all of the stars have essentially the same age and were born from the same cloud of gas. Furthermore, with an age of ~650 Myr, most of the intermediate- and low-mass stars are on the main sequence. Given these assumptions, the accretion of metal-rich material onto the surface of a star during and shortly after the formation of planetary systems should be evident via the enhanced metallicity of the star. Building on previous work, stellar evolution models that include the effects of stellar pollution …

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Mobicom Poster: Evaluating Location Predictors With Extensive Wi-Fi Mobility Data, Libo Song, David Kotz, Ravi Jain, Xiaoning He Oct 2003

Mobicom Poster: Evaluating Location Predictors With Extensive Wi-Fi Mobility Data, Libo Song, David Kotz, Ravi Jain, Xiaoning He

Dartmouth Scholarship

A fundamental problem in mobile computing and wireless networks is the ability to track and predict the location of mobile devices. An accurate location predictor can significantly improve the performance or reliability of wireless network protocols, the wireless network infrastructure itself, and many applications in pervasive computing. These improvements lead to a better user experience, to a more cost-effective infrastructure, or both. Location prediction has been proposed in many areas of wireless cellular networks as a means of enhancing performance, including better mobility management, improved assignment of cells to location areas, more efficient paging, and call admission control. To the …

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Gauge-Invariant Initial Conditions And Early Time Perturbations In Quintessence Universes, Michael Doran, Christian M. Müller, Gregor Schäfer, Christof Wetterich Sep 2003

Gauge-Invariant Initial Conditions And Early Time Perturbations In Quintessence Universes, Michael Doran, Christian M. Müller, Gregor Schäfer, Christof Wetterich

Dartmouth Scholarship

We present a systematic treatment of the initial conditions and evolution of cosmological perturbations in a universe containing photons, baryons, neutrinos, cold dark matter, and a scalar quintessence field. By formulating the evolution in terms of a differential equation involving a matrix acting on a vector comprised of the perturbation variables, we can use the familiar language of eigenvalues and eigenvectors. As the largest eigenvalue of the evolution matrix is fourfold degenerate, it follows that there are four dominant modes with a nondiverging gravitational potential at early times, corresponding to adiabatic, cold dark matter isocurvature, baryon isocurvature and neutrino isocurvature …

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Impact Of Frustrated Singularities On Magnetic Island Evolution, B. D. Jemella, M. A. Shay, J. F. Drake, B. N. Rogers Sep 2003

Impact Of Frustrated Singularities On Magnetic Island Evolution, B. D. Jemella, M. A. Shay, J. F. Drake, B. N. Rogers

Dartmouth Scholarship

The growth of magnetic islands is explored using the magnetohydrodynamic model in a simple slab system in which the value of the tearing mode stability parameter Δ′ can be varied continuously. Unless the system is close to marginal stability reconnection is controlled by Sweet-Parker current layers, whose formation is a consequence of the inherent singular structure of magnetic island equilibria.

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High-Throughput 3d Homology Detection Via Nmr Resonance Assignment, Christopher James Langmead, Bruce Randall Donald Sep 2003

High-Throughput 3d Homology Detection Via Nmr Resonance Assignment, Christopher James Langmead, Bruce Randall Donald

Computer Science Technical Reports

One goal of the structural genomics initiative is the identification of new protein folds. Sequence-based structural homology prediction methods are an important means for prioritizing unknown proteins for structure determination. However, an important challenge remains: two highly dissimilar sequences can have similar folds --- how can we detect this rapidly, in the context of structural genomics? High-throughput NMR experiments, coupled with novel algorithms for data analysis, can address this challenge. We report an automated procedure, called HD, for detecting 3D structural homologies from sparse, unassigned protein NMR data. Our method identifies 3D models in a protein structural database whose geometries …

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An Improved Nuclear Vector Replacement Algorithm For Nuclear Magnetic Resonance Assignment, Christopher James Langmead, Bruce Randall Donald Sep 2003

An Improved Nuclear Vector Replacement Algorithm For Nuclear Magnetic Resonance Assignment, Christopher James Langmead, Bruce Randall Donald

Computer Science Technical Reports

We report an improvement to the Nuclear Vector Replacement (NVR) algorithm for high-throughput Nuclear Magnetic Resonance (NMR) resonance assignment. The new algorithm improves upon our earlier result in terms of accuracy and computational complexity. In particular, the new NVR algorithm assigns backbone resonances without error (100% accuracy) on the same test suite examined in [Langmead and Donald J. Biomol. NMR 2004], and runs in $O(n^{5/2} \log {(cn)})$ time where $n$ is the number of amino acids in the primary sequence of the protein, and $c$ is the maximum edge weight in an integer-weighted bipartite graph.

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A Model Of Zebra Emission In Solar Type Iv Radio Bursts, J. Labelle, R. A. Treumann, P. H. Yoon, M. Karlicky Aug 2003

A Model Of Zebra Emission In Solar Type Iv Radio Bursts, J. Labelle, R. A. Treumann, P. H. Yoon, M. Karlicky

Dartmouth Scholarship

Solar type IV radio bursts present a theoretical challenge because they are composed of both continuum emission and fine structures. The latter include "zebra bursts," which appear as harmonically spaced multiplets that shift in frequency with time. Similarities between these features and terrestrial auroral emissions suggest a new model to explain zebra-structured type IV emissions. In this model, the basic generation mechanism is identical with that proposed by Winglee and Dulk: mode conversion of Z-mode waves generated by the cyclotron maser mechanism under the condition fuh = Nfce, with N an integer; however, we propose a twist …

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Bear: An Open-Source Virtual Secure Coprocessor Based On Tcpa, Rich Macdonald, Sean Smith, John Marchesini, Omen Wild Aug 2003

Bear: An Open-Source Virtual Secure Coprocessor Based On Tcpa, Rich Macdonald, Sean Smith, John Marchesini, Omen Wild

Computer Science Technical Reports

This paper reports on our ongoing project to use TCPA to transform a desktop Linux machine into a virtual secure coprocessor: more powerful but less secure than higher-end devices. We use TCPA hardware and modified boot loaders to protect fairly static components, such as a trusted kernel; we use an enforcer module---configured as Linux Security Module---to protected more dynamic system components; we use an encrypted loopback filesystem to protect highly dynamic components. All our code is open source and available under GPL from http://enforcer.sourceforge.net/

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Phantom Energy: Dark Energy With W < − 1 Causes A Cosmic Doomsday, Robert R. Caldwell, Marc Kamionkowski, Nevin N. Weinberg Aug 2003

Phantom Energy: Dark Energy With W < − 1 Causes A Cosmic Doomsday, Robert R. Caldwell, Marc Kamionkowski, Nevin N. Weinberg

Dartmouth Scholarship

We explore the consequences that follow if the dark energy is phantom energy, in which the sum of the pressure and energy density is negative. The positive phantom-energy density becomes infinite in finite time, overcoming all other forms of matter, such that the gravitational repulsion rapidly brings our brief epoch of cosmic structure to a close. The phantom energy rips apart the Milky Way, solar system, Earth, and ultimately the molecules, atoms, nuclei, and nucleons of which we are composed, before the death of the Universe in a “big rip.”

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Formal Properties Of Linear Memory Types, Heng Huang, Lea Wittie, Chris Hawblitzel Aug 2003

Formal Properties Of Linear Memory Types, Heng Huang, Lea Wittie, Chris Hawblitzel

Computer Science Technical Reports

Efficient low-level systems need more control over memory than safe high-level languages usually provide. As a result, run-time systems are typically written in unsafe languages such as C. This report describes an abstract machine designed to give type-safe code more control over memory. It includes complete definitions and proofs of preservation, progress, strong normalization, erasure, and translation correctness.

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Using Caching For Browsing Anonymity, Anna M. Shubina, Sean W. Smith Jul 2003

Using Caching For Browsing Anonymity, Anna M. Shubina, Sean W. Smith

Computer Science Technical Reports

Privacy-providing tools, including tools that provide anonymity, are gaining popularity in the modern world. Among the goals of their users is avoiding tracking and profiling. While some businesses are unhappy with the growth of privacy-enhancing technologies, others can use lack of information about their users to avoid unnecessary liability and even possible harassment by parties with contrary business interests, and to gain a competitive market edge. Currently, users interested in anonymous browsing have the choice only between single-hop proxies and the few more complex systems that are available. These still leave the user vulnerable to long-term intersection attacks. In this …

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The Mistaken Axioms Of Wireless-Network Research, David Kotz, Calvin Newport, Chip Elliott Jul 2003

The Mistaken Axioms Of Wireless-Network Research, David Kotz, Calvin Newport, Chip Elliott

Computer Science Technical Reports

Most research on ad-hoc wireless networks makes simplifying assumptions about radio propagation. The ``Flat Earth'' model of the world is surprisingly popular: all radios have circular range, have perfect coverage in that range, and travel on a two-dimensional plane. CMU's ns-2 radio models are better but still fail to represent many aspects of realistic radio networks, including hills, obstacles, link asymmetries, and unpredictable fading. We briefly argue that key ``axioms'' of these types of propagation models lead to simulation results that do not adequately reflect real behavior of ad-hoc networks, and hence to network protocols that may not work well …

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Early Quintessence In Light Of Thewilkinson Microwave Anisotropy Probe, Robert R. Caldwell, Michael Doran, Christian M. Mller, Gregor Schfer, Christof Wetterich Jul 2003

Early Quintessence In Light Of Thewilkinson Microwave Anisotropy Probe, Robert R. Caldwell, Michael Doran, Christian M. Mller, Gregor Schfer, Christof Wetterich

Dartmouth Scholarship

We examine the cosmic microwave background (CMB) anisotropy for signatures of early quintessence dark energy—a nonnegligible quintessence energy density during the recombination and structure formation eras. Only very recently does the quintessence overtake the dark matter and push the expansion into overdrive. Because the presence of early quintessence exerts an influence on the clustering of dark matter and the baryon-photon fluid, we may expect to find trace signals in the CMB and the mass fluctuation power spectrum. In detail, we demonstrate that suppressed clustering power on small length scales, as suggested by the combined Wilkinson Microwave Anisotropy Probe/CMB/large-scale structure …

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Grb 021004: A Possible Shell Nebula Around A Wolf‐Rayet Star Gamma‐Ray Burst Progenitor, N. Mirabal, J. P. Halpern, Ryan Chornock, Alexei V. Filippenko, D. M. Terndrup, E. Armstrong, J. Kemp, J. R. Thorstensen, M. Tavarez, C. Espaillat Jun 2003

Grb 021004: A Possible Shell Nebula Around A Wolf‐Rayet Star Gamma‐Ray Burst Progenitor, N. Mirabal, J. P. Halpern, Ryan Chornock, Alexei V. Filippenko, D. M. Terndrup, E. Armstrong, J. Kemp, J. R. Thorstensen, M. Tavarez, C. Espaillat

Dartmouth Scholarship

The rapid localization of GRB 021004 by the HETE-2 satellite allowed nearly continuous monitoring of its early optical afterglow decay, as well as high-quality optical spectra that determined a redshift of z3 = 2.328 for its host galaxy, an active starburst galaxy with strong Ly emission and several absorption lines. Spectral observations show multiple absorbers at z3A = 2.323, z3B= 2.317, and z3C = 2.293 blueshifted by ~450, ~990, and ~3155 km s-1, respectively, relative to the host galaxy Lyα emission. We argue that these correspond to a fragmented shell nebula that has …

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Discrete-Event Fluid Modeling Of Background Tcp Traffic, David M. Nicol, Guanhua Yan Jun 2003

Discrete-Event Fluid Modeling Of Background Tcp Traffic, David M. Nicol, Guanhua Yan

Computer Science Technical Reports

TCP is the most widely used transport layer protocol used in the internet today. A TCP session adapts the demands it places on the network to observations of bandwidth availability on the network. Because TCP is adaptive, any model of its behavior that aspires to be accurate must be influenced by other network traffic. This point is especially important in the context of using simulation to evaluate some new network algorithm of interest (e.g. reliable multi-cast) in an environment where the background traffic affects---and is affected by---its behavior. We need to generate background traffic efficiently in a way that captures …

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Efficient And Practical Constructions Of Ll/Sc Variables, Prasad Jayanti, Srdjan Petrovic Jun 2003

Efficient And Practical Constructions Of Ll/Sc Variables, Prasad Jayanti, Srdjan Petrovic

Computer Science Technical Reports

Over the past decade, LL/SC have emerged as the most suitable synchronization instructions for the design of lock-free algorithms. However, current architectures do not support these instructions; instead, they support either CAS or RLL/RSC (e.g. POWER4, MIPS, SPARC, IA-64). To bridge this gap, this paper presents two efficient wait-free algorithms for implementing 64-bit LL/SC objects from 64-bit CAS or RLL/RSC objects. Our first algorithm is practical: it has a small, constant time complexity (of 4 for LL and 5 for SC) and a space overhead of only 4 words per process. This algorithm uses unbounded sequence numbers. For theoretical interest, …

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Distributed Planning And Control For Modular Robots With Unit-Compressible Modules, Zack Butler, Daniela Rus Jun 2003

Distributed Planning And Control For Modular Robots With Unit-Compressible Modules, Zack Butler, Daniela Rus

Computer Science Technical Reports

Self-reconfigurable robots are versatile systems consisting of large numbers of independent modules. Effective use of these systems requires parallel actuation and planning, both for efficiency and independence from a central controller. This paper presents the PacMan algorithm, a technique for distributed actuation and planning for systems with two- or three-dimensional unit-compressible modules. We give two versions of the algorithm along with correctness analysis. We also analyze the parallel actuation capability of the algorithm, showing that it will not deadlock and will avoid disconnecting the robot. We have implemented PacMan on the Crystal robot, a hardware system developed in our lab, …

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A Surface-Based Approach For Classification Of 3d Neuroanatomic Structures, Li Shen, James Ford, Fillia Makedon, Andrew Saykin Jun 2003

A Surface-Based Approach For Classification Of 3d Neuroanatomic Structures, Li Shen, James Ford, Fillia Makedon, Andrew Saykin

Computer Science Technical Reports

We present a new framework for 3D surface object classification that combines a powerful shape description method with suitable pattern classification techniques. Spherical harmonic parameterization and normalization techniques are used to describe a surface shape and derive a dual high dimensional landmark representation. A point distribution model is applied to reduce the dimensionality. Fisher's linear discriminants and support vector machines are used for classification. Several feature selection schemes are proposed for learning better classifiers. After showing the effectiveness of this framework using simulated shape data, we apply it to real hippocampal data in schizophrenia and perform extensive experimental studies by …

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Digital Art Forensics, Siwei Lyu, Daniel Rockmore, Hany Farid Jun 2003

Digital Art Forensics, Siwei Lyu, Daniel Rockmore, Hany Farid

Computer Science Technical Reports

We describe a computational technique for digitally authenticating works of art. This approach builds statistical models of an artist from a set of authenticated works. Additional works are then authenticated against this model. The statistical model consists of first- and higher-order wavelet statistics. We show preliminary results from our analysis of thirteen drawings by Pieter Bruegel the Elder. We also present preliminary results showing how these techniques may be applicable to determining how many hands contributed to a single painting.

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The Kerf Toolkit For Intrusion Analysis (Poster Abstract), Javed Aslam, Sergey Bratus, David Kotz, Ron Peterson, Daniela Rus, Brett Tofel Jun 2003

The Kerf Toolkit For Intrusion Analysis (Poster Abstract), Javed Aslam, Sergey Bratus, David Kotz, Ron Peterson, Daniela Rus, Brett Tofel

Dartmouth Scholarship

We consider the problem of intrusion analysis and present the Kerf toolkit, whose purpose is to provide an efficient and flexible infrastructure for the analysis of attacks. The Kerf toolkit includes a mechanism for securely recording host and network logging information for a network of workstations, a domain-specific language for querying this stored data, and an interface for viewing the results of such a query, providing feedback on these results, and generating new queries in an iterative fashion. We describe the architecture of Kerf in detail, present examples to demonstrate the power of our query language, and discuss the performance …

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Spatially Resolved Spectroscopy Of Coma Cluster Early-Type Galaxies - Iii. The Stellar Population Gradients, D. Mehlert, D. Thomas, R. P. Saglia, R. Bender, G Wegner May 2003

Spatially Resolved Spectroscopy Of Coma Cluster Early-Type Galaxies - Iii. The Stellar Population Gradients, D. Mehlert, D. Thomas, R. P. Saglia, R. Bender, G Wegner

Dartmouth Scholarship

Based on Paper I of this series (Mehlert et al. 2000), we derive central values and logarithmic gradients for the Hβ, Mg and Fe indices of 35 early-type galaxies in the Coma cluster. We find that pure elliptical galaxies have on average slightly higher velocity dispersions, lower Hβ, and higher metallic line-strengths than galaxies with disks (S0). The latter form two families, one comparable to the ellipticals and a second one with significantly higher Hβ, and weaker metallic lines. Our measured logarithmic gradients within the effective radius are ⟨△Mg b⟩ ≈ −0.037, ⟨△⟨Fe⟩⟩ ≈ −0.029, ⟨△Hβ⟩ ≈ +0.017 and ⟨△σ⟩ …

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Effects Of The Sound Speed Of Quintessence On The Microwave Background And Large Scale Structure, Simon Dedeo, R. R. Caldwell, Paul J. Steinhardt May 2003

Effects Of The Sound Speed Of Quintessence On The Microwave Background And Large Scale Structure, Simon Dedeo, R. R. Caldwell, Paul J. Steinhardt

Dartmouth Scholarship

We consider how quintessence models in which the sound speed differs from the speed of light and varies with time affect the cosmic microwave background and the fluctuation power spectrum. Significant modifications occur on length scales related to the Hubble radius during epochs in which the sound speed is near zero and the quintessence contributes a non-negligible fraction of the total energy density. For the microwave background, we find that the usual enhancement of the lowest multipole moments by the integrated Sachs-Wolfe effect can be modified, resulting in suppression or bumps instead. Also, the sound speed can produce oscillations and …

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Regulation And Localization Of Endogenous Human Tristetraprolin, Anna-Marie Fairhurst, John E. Connolly, Katharine A Hintz, Nicolas J Goulding May 2003

Regulation And Localization Of Endogenous Human Tristetraprolin, Anna-Marie Fairhurst, John E. Connolly, Katharine A Hintz, Nicolas J Goulding

Dartmouth Scholarship

Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis. To define its intracellular location and examine its regulation of TNF, a quantitive intracellular staining assay specific for TTP was developed. We establish for the first time that in peripheral blood leukocytes, express

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