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Articles 1 - 14 of 14
Full-Text Articles in Physical Sciences and Mathematics
Enhanced Breast Cancer Tumor Classification Using Mobilenetv2: A Detailed Exploration On Image Intensity, Error Mitigation, And Streamlit-Driven Real-Time Deployment, Aaditya Surya, Aditya Keshary Shah, Subash Tarun Sasikumar, Jarnell Kabore
Enhanced Breast Cancer Tumor Classification Using Mobilenetv2: A Detailed Exploration On Image Intensity, Error Mitigation, And Streamlit-Driven Real-Time Deployment, Aaditya Surya, Aditya Keshary Shah, Subash Tarun Sasikumar, Jarnell Kabore
Butler Journal of Undergraduate Research
This research introduces a sophisticated transfer learning model based on Google’s MobileNetV2 for breast cancer tumor classification into normal, benign, and malignant categories, utilizing a dataset of 1576 ultrasound images (265 normal, 891 benign, 420 malignant). The model achieves an accuracy of 0.82, precision of 0.83, recall of 0.81, ROC-AUC of 0.94, PR-AUC of 0.88, and MCC of 0.74. It examines image intensity distributions and misclassification errors, offering improvements for future applications. Addressing dataset imbalances, the study ensures a generalizable model. This work, using a dataset from Baheya Hospital, Cairo, Egypt, compiled by Walid Al- Dhabyani and colleagues (2020), emphasizes …
Adding Gas Chromatography-Mass Spectrometry Data To A Melting Point And Thin-Layer Chromatography Laboratory, Adam M. Azman, Julie A. Barrett, Megan Darragh, John J. Esteb
Adding Gas Chromatography-Mass Spectrometry Data To A Melting Point And Thin-Layer Chromatography Laboratory, Adam M. Azman, Julie A. Barrett, Megan Darragh, John J. Esteb
Scholarship and Professional Work - LAS
The addition of gas chromatography–mass spectrometry (GC–MS) data interpretation to a thin-layer chromatography (TLC) and melting point (mp) laboratory for an introductory organic course is described.
Technology For The Organic Chemist: Three Exploratory Modules, John J. Esteb, Luanne M. Mcnulty, John Magers, Paul Morgan
Technology For The Organic Chemist: Three Exploratory Modules, John J. Esteb, Luanne M. Mcnulty, John Magers, Paul Morgan
Scholarship and Professional Work - LAS
The ability to use computer-based technology is an essential skill set for students majoring in chemistry. This exercise details the introduction of appropriate uses for this technology in the organic chemistry series. The incorporation of chemically appropriate online resources (module 1), scientific databases (module 2), and the use of a chemical drawing program (module 3) are detailed here.
A Flexible Solvolysis Experiment For The Undergraduate Organic Laboratory, John J. Esteb, John R. Magers, Luanne M. Mcnulty, Paul Morgan
A Flexible Solvolysis Experiment For The Undergraduate Organic Laboratory, John J. Esteb, John R. Magers, Luanne M. Mcnulty, Paul Morgan
Scholarship and Professional Work - LAS
A simple SN1 reaction is presented that uses bromotriphenylmethane and a range of oxygen-based nucleophiles including water and various alcohols. This procedure represents a process that affords easy isolation of solid products. Typical student yields ranged from 17–128% with the average yield of 50%. Students obtained products with a melting point range of 140 to 164 °C. This procedure offers multiple ways to adapt this experiment from a straight solvolysis reaction to a discovery-based experiment that explores the effect of nucleophile (for a more advanced group) or the method of product isolation.
A Simple Sn2 Reaction For The Undergraduate Organic Laboratory, John J. Esteb
A Simple Sn2 Reaction For The Undergraduate Organic Laboratory, John J. Esteb
Scholarship and Professional Work - LAS
A simple procedure for the synthesis of n-butyl naphthyl ether is presented. This procedure represents an easy method for the production of an aryl ether by an SN2 reaction, uses ethanol as an environmentally friendly solvent, and does not require the use of a lachrymator. Product isolation is done by pouring the reaction mixture over ice and collecting the solid by suction filtration. Students typically recover from 7–95% of the ether.
Temperature-Driven Transition From The Wigner Crystal To The Bond-Charge-Density Wave In The Quasi-One-Dimensional Quarter-Filled Band, Rahul Hardikar
Temperature-Driven Transition From The Wigner Crystal To The Bond-Charge-Density Wave In The Quasi-One-Dimensional Quarter-Filled Band, Rahul Hardikar
Scholarship and Professional Work - LAS
It is known that within the interacting electron model Hamiltonian for the one-dimensional 14-filled band, the singlet ground state is a Wigner crystal only if the nearest-neighbor electron-electron repulsion is larger than a critical value. We show that this critical nearest-neighbor Coulomb interaction is different for each spin subspace, with the critical value decreasing with increasing spin. As a consequence, with the lowering of temperature, there can occur a transition from a Wigner crystal charge-ordered state to a spin-Peierls state that is a bond-charge-density wave with charge occupancies different from the Wigner crystal. This transition is possible because spin excitations …
On The Size Of Succinct Indices, Alexander Golynski, Ankur Gupta
On The Size Of Succinct Indices, Alexander Golynski, Ankur Gupta
Scholarship and Professional Work - LAS
A succinct data structure occupies an amount of space that is close to the information-theoretic minimum plus an additional term. The latter is not necessarily a lower-order term and, in several cases, completely dominates the space occupancy both in theory and in practice. In this paper, we present several solutions to partially overcome this problem, introducing new techniques of independent interest that allow us to improve over previously known upper and lower bounds.
Projects That Assist With Content In A Traditional Organic Chemistry Course, John J. Esteb, John R. Magers, Luanne Mcnulty, Anne M. Wilson
Projects That Assist With Content In A Traditional Organic Chemistry Course, John J. Esteb, John R. Magers, Luanne Mcnulty, Anne M. Wilson
Scholarship and Professional Work - LAS
Projects that engage undergraduate students in content-based courses, such as organic chemistry, must relate to the material and provide useful tools for the divergent needs of the students. There are few examples of these types of projects in the literature. Herein, we describe two projects, the reaction notebook and the end-of-semester synthesis activity. Each project is designed to stimulate student ownership of the material and leads to engagement with the content of the course.
A Solvent-Free Baeyer–Villiger Lactonization For The Undergraduate Organic Laboratory: Synthesis Of Γ-T-Butyl-Ε-Caprolactone, John J. Esteb, James N. Hohman, Diana E. Schladaminger, Anne M. Wilson
A Solvent-Free Baeyer–Villiger Lactonization For The Undergraduate Organic Laboratory: Synthesis Of Γ-T-Butyl-Ε-Caprolactone, John J. Esteb, James N. Hohman, Diana E. Schladaminger, Anne M. Wilson
Scholarship and Professional Work - LAS
We present an experiment involving the Baeyer–Villiger oxidation reactionfor a first-year organic chemistry class. The Baeyer–Villiger reactionprovides an efficient method to convert ketones to esters or lactones. Most organictextbooks cover the Baeyer–Villiger reaction but owing to a lack of suitableexperiments, students seldom get to explore the reaction in the undergraduateteaching laboratory. In this experiment, m-chloroperoxybenzoic acid(m-CPBA) and4-tert-butylcyclohexanone are mixed together for 30 minutes under solvent-freeconditions to produce γ-t-butyl-ε-caprolactone in 95%yield. The solvent-free nature of this procedure greatly limits the quantityof waste generated by students and keeps costs low by removing the need for solvent.
Solvent-Free Conversion Of Alpha-Naphthaldehyde To 1-Naphthoic Acid And 1-Naphthalenemethanol: Application Of The Cannizzaro Reaction, John J. Esteb, Keith M. Glogorich, Stacey A. O'Reilly
Solvent-Free Conversion Of Alpha-Naphthaldehyde To 1-Naphthoic Acid And 1-Naphthalenemethanol: Application Of The Cannizzaro Reaction, John J. Esteb, Keith M. Glogorich, Stacey A. O'Reilly
Scholarship and Professional Work - LAS
The Cannizzaro reaction is routinely covered in organic textbooks, but owing to the shortage of suitable procedures for the undergraduate teaching laboratory, this reaction is seldom performed in a first-year organic chemistry class. In this experiment, powdered potassium hydroxide and α-naphthaldehyde are heated under solvent-free conditions to produce 1-naphthoic acid and 1-naphthalenemethanol in 86% and 79% yields, respectively. The solvent-free nature of this procedure greatly reduces the quantity of waste generated by students relative to the typical solvent-based method of preparation. Note:Link is to the article in a subscription database available to users affiliated with Butler University. Appropriate login information …
Simple Epoxide Formation For The Organic Laboratory Using Oxone, John J. Esteb
Simple Epoxide Formation For The Organic Laboratory Using Oxone, John J. Esteb
Scholarship and Professional Work - LAS
We present an epoxide formation experiment for a second-semester organic chemistry laboratory. This oxidation utilizes Oxone, a commercially available oxidizing agent, in the industrially relevant process of epoxide formation. The oxidant performing the oxidation is dimethyldioxirane, which is formed in situ. This experiment demonstrates a simple synthesis of an epoxide and formation of a secondary oxidizing agent.
Cautionary Comments (Author Response), John J. Esteb, Anne M. Wilson
Cautionary Comments (Author Response), John J. Esteb, Anne M. Wilson
Scholarship and Professional Work - LAS
Reply to concerns about a safety factor in the paper, “A Solvent-Free Oxidation of Alcohols in an Organic Laboratory."
A Solvent-Free Oxidation Of Alcohols In An Organic Laboratory, John J. Esteb, Michael W. Schelle, Anne N. Wilson
A Solvent-Free Oxidation Of Alcohols In An Organic Laboratory, John J. Esteb, Michael W. Schelle, Anne N. Wilson
Scholarship and Professional Work - LAS
An oxidation experiment for a first-year organic chemistry class is presented. This oxidation utilizes a solid mixture of CuSO4•5H2O and KMnO4 prepared by mortar and pestle. The oxidations take place under solvent-free conditions and near quantitative yields are obtained for the reactions. Thin-layer chromatography is used to monitor the progress of the reaction. This experiment provides for the simple oxidation of a secondary alcohol to a ketone using a relatively nontoxic oxidizing agent under solvent-free conditions.
A Solvent-Free Claisen Condensation Reaction For The Organic Laboratory, John J. Esteb, Matthew B. Stockton
A Solvent-Free Claisen Condensation Reaction For The Organic Laboratory, John J. Esteb, Matthew B. Stockton
Scholarship and Professional Work - LAS
An experiment involving the Claisen condensation reaction for a first-year organic chemistry laboratory is presented. Claisen condensations are routinely covered in organic textbooks but owing to the long reaction times required to reach equilibrium in solution they are seldom explored in the undergraduate teaching laboratory. In this experiment, potassium tert-butoxide and ethyl phenylacetate are heated to 100 °C for 30 minutes under solvent-free conditions to produce 2,4-diphenyl acetoacetate in 80% yield. The solvent-free nature of this procedure greatly reduces the quantity of waste generated by students relative to typical carbonyl condensation experiments.