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Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
An Investigation Of The Relationship Between Math Curricula And Students' College Readiness, Nancy A. Deluca
An Investigation Of The Relationship Between Math Curricula And Students' College Readiness, Nancy A. Deluca
Scholar Week 2016 - present
State learning standards with increased rigor have required higher levels of achievement from students on standardized tests, high-school grades, and national percentile ranks which are used for collegiate acceptance and course placement. As a result, preparation of students for standardized tests such as the ACT and SAT have become increasingly more challenging. The current quantitative, quasi-experimental study examined the relationship between the tangible math curricula used for instruction and students’ readiness for collegiate coursework. From sample sizes of 128 and 169 high-school students in two consecutive school years, there were several statistically significant relationship differences. Analysis of test results indicated …
Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven
Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven
Scholar Week 2016 - present
Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there …
Computational Chemistry - Ulk 101, Michaela Montpas
Computational Chemistry - Ulk 101, Michaela Montpas
Scholar Week 2016 - present
Autophagy is a process that generates the necessary building components for cells by cytoplasmic breakdown of unnecessary materials (Martin, Celano, Solitro, Gunaydin, Scott, et. al., 2018). This is a survival technique for cells in times of stress, especially during periods of nutrient starvation. Cancer cells, unfortunately, benefit from this process due to their ability to flourish in nutrient-starved environments, becoming resistant to therapy. The primary protein in mammals responsible for this process is a serine/threonine kinase called ULK 1 (unc-51 like autophagy initiating kinase 1). As such, inhibitors of ULK 1 can be used in cancer therapies in order to …