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Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
Opening Of An Epoxide Ring Using Azide To Form A Triazole, Emily Hufnagel, Jeffrey A. Hansen
Opening Of An Epoxide Ring Using Azide To Form A Triazole, Emily Hufnagel, Jeffrey A. Hansen
Annual Student Research Poster Session
No abstract provided.
Synthesis Of Ether Alcohols With Varying Catalysts, Hannah Grady, Frida Li, Jeffrey A. Hansen
Synthesis Of Ether Alcohols With Varying Catalysts, Hannah Grady, Frida Li, Jeffrey A. Hansen
Annual Student Research Poster Session
No abstract provided.
Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage
Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage
Scholar Week 2016 - present
The Ph.D. research by Douglas Armstrong was highly successful for the synthesis of the trans cyclopropyl analog of acetylcholine, but only marginally successful for the cis isomer. In recent years he has developed novel ideas as to how the synthesis of the cis isomer may be improved upon, in ways using more current methods. He has done experiments using some of those methods, and the results, although preliminary, look good.
Synthesis Of A Sulfur Variant For Treatment Of Trypanosomiasis, Carlos Vera-Esquivel
Synthesis Of A Sulfur Variant For Treatment Of Trypanosomiasis, Carlos Vera-Esquivel
UNO Student Research and Creative Activity Fair
Previous work in our lab has found diphenyl ether benzylamines showed a successful response with a micromolar concentration of our lead compound to treat the deadly Trypanosamiosis rhodesience. Furthermore, mammalian cell lines saw promising resistance towards damages. The goal of this study was to synthesize a diphenyl thio benzylamine variant. This variant was more active toward T. b. rhodesience but showed more toxicity to both rat 10 (IC50 mM) and human cell lines (HFF, HC-04, U-2 OS, and HEK293). The selectivity index (ratio of toxicity to activity in the same concentration units (SI)) …