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Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven
Synthesis Of Cyclopropyl Analogs Of Stereochemically Rigid Probes Of Certain Pharmacological Receptors, Douglas Armstrong, Zachary Emptage, Anderson Verhoeven
Scholar Week 2016 - present
Douglas Armstrong, lead ONU faculty researcher, and his two research students, Zachary Emptage and Anderson Verhoeven, expanded their previous research (centered around acetylcholine and cholinergic activity), to include other types of pharmacological receptors, but again, aiming at the same type of compounds (cyclopropyl) to confer conformational (stereochemical) rigidity. The focus now is on compounds which, like acetylcholine, also contain an oxygen atom and a nitrogen atom separated by two carbon atoms, but which have pharmacological activity other than cholinergic. Several pharmacological categories have this pattern as known medicinal agents (“drugs”), including certain antidepressants, antihistamines, anti-anxiety drugs, etc. For some, there …
Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage
Synthesis Of Cyclopropyl Analogs Of Acetylcholine, Douglas Armstrong, Zachary Emptage
Scholar Week 2016 - present
The Ph.D. research by Douglas Armstrong was highly successful for the synthesis of the trans cyclopropyl analog of acetylcholine, but only marginally successful for the cis isomer. In recent years he has developed novel ideas as to how the synthesis of the cis isomer may be improved upon, in ways using more current methods. He has done experiments using some of those methods, and the results, although preliminary, look good.