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Coupled Dynamics Of Voltage And Calcium In Paced Cardiac Cells, Yohannes Shiferaw, Daisuke Sato, Alain Karma
Coupled Dynamics Of Voltage And Calcium In Paced Cardiac Cells, Yohannes Shiferaw, Daisuke Sato, Alain Karma
Alain Karma
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.