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Full-Text Articles in Physical Sciences and Mathematics
Research Needs For The Risk Assessment Of Health And Environmental Effects Of Endocrine Disruptors: A Report Of The Us Epa-Sponsored Workshop, Rj Kavlock, Gp Daston, C Derosa, P Fennercrisp, Le Gray, S Kaattari, Et Al
Research Needs For The Risk Assessment Of Health And Environmental Effects Of Endocrine Disruptors: A Report Of The Us Epa-Sponsored Workshop, Rj Kavlock, Gp Daston, C Derosa, P Fennercrisp, Le Gray, S Kaattari, Et Al
VIMS Articles
The hypothesis has been put forward that humans and wildlife species have suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency sponsored a workshop in April 1995 to bring together interested parties in an effort to identify research gaps related to this hypothesis and to establish priorities for future research activities. Approximately 90 invited participants were organized into work groups developed around the principal reported health effects-carcinogenesis, reproductive toxicity, neurotoxicity, and immunotoxicity--as well as along the risk assessment paradigm--hazard identification, dose-response …
Expression Of The Xenobiotic Transporter P-Glycoprotein In The Mummichog (Fundulus Heteroclitus), Peter S. Cooper
Expression Of The Xenobiotic Transporter P-Glycoprotein In The Mummichog (Fundulus Heteroclitus), Peter S. Cooper
Dissertations, Theses, and Masters Projects
The mammalian mdr1 P-glycoprotein (Pgp) has been implicated in xenobiotic resistance of drug-resistant cell lines and tumors, and may function in excretion or exclusion of toxic xenobiotics at several sites within the body. Pgp gene family members are expressed in excretory epithelia of several aquatic taxa and may contribute to the survival of pollution-tolerant aquatic animals in contaminated environments. For this reason the expression of Pgp family members was investigated in the livers and liver tumors of creosote-resistant mummichog (Fundulus heteroclitus) inhabiting a creosote-contaminated site (Atlantic Wood) in the Elizabeth River, Virginia. Expression of members of the Pgp gene family …
Demersal Predator Exposure To Toxic Organic Contaminants: Direct Effects Of Macrofauna In Trophic Transfer, Patrick Winfield Lay
Demersal Predator Exposure To Toxic Organic Contaminants: Direct Effects Of Macrofauna In Trophic Transfer, Patrick Winfield Lay
Dissertations, Theses, and Masters Projects
The bioaccumulation and metabolism of organic contaminants (PAH, PCB) by three estuarine polychaetes, Nereis succinea (Frey and Leuckart 1847), Paraprionospio pinnata (Ehlers 1901) and Polydora ligni (Webster 1879), and by the fish predator, spot (Leiostomus xanthurus Lacepede 1802), were examined in laboratory experiments. Variations in trophic transfer of these contaminants resulting from differences in prey and contaminant type were also investigated. Toxicokinetic modeling reveals that metabolism of organic contaminants by invertebrate species result in variations in uptake, metabolism and elimination rate constants. Incorporation of prey metabolism potential in kinetic models increases the latter's predictability of biota-sediment accumulation factors (BSAFs), or …