Physical Sciences and Mathematics Commons^™

Methods For Joint Normalization And Comparison Of Hi-C Data, John C. Stansfield

Theses and Dissertations

The development of chromatin conformation capture technology has opened new avenues of study into the 3D structure and function of the genome. Chromatin structure is known to influence gene regulation, and differences in structure are now emerging as a mechanism of regulation between, e.g., cell differentiation and disease vs. normal states. Hi-C sequencing technology now provides a way to study the 3D interactions of the chromatin over the whole genome. However, like all sequencing technologies, Hi-C suffers from several forms of bias stemming from both the technology and the DNA sequence itself. Several normalization methods have been developed for normalizing …

Comparison Of Survival Curves Between Cox Proportional Hazards, Random Forests, And Conditional Inference Forests In Survival Analysis, Brandon Weathers

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Survival analysis methods are a mainstay of the biomedical fields but are finding increasing use in other disciplines including finance and engineering. A widely used tool in survival analysis is the Cox proportional hazards regression model. For this model, all the predicted survivor curves have the same basic shape, which may not be a good approximation to reality. In contrast the Random Survival Forests does not make the proportional hazards assumption and has the flexibility to model survivor curves that are of quite different shapes for different groups of subjects. We applied both techniques to a number of publicly available …

A Comparison Of Prediction Methods Of Functional Autoregressive Time Series, Devin Didericksen

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Functional data analysis (FDA) is a relatively new branch of statistics that has seen a lot of expansion recently. With the advent of computer processing power and more efficient software packages we have entered the beginning stages of applying FDA methodology and techniques to data. Part of this undertaking should include an empirical assessment of the effectiveness of some of the tools of FDA, which are sound on theoretical grounds. In a small way, this project helps advance this objective.

This work begins by introducing FDA, scalar prediction techniques, and the functional autoregressive model of order one - FAR(1). Two …

Cow Insurance Vs. Human Insurance: A Comparison Study, Corlan Fawcett

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This paper will compare the premiums to insure cows and humans for n-year term, n-year endowment, and whole life insurance. It will go into more depth for whole life premium s that would be charged, such that the insurance company is 95 percent confident that they will not lose money. In particular the paper will look at how the variance affects the premiums for an insurance company insuring 100 cows.

Comparison Of Exact Methods For Analyzing Family-Based Samples, Abbie Lundgreen

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Family-based association tests are used to identify genes that increase the risk of developing a disease, while controlling for spurious associations caused by population structure. The exact family-based association test, exact FBAT, is a unified approach which can be app lied to tests of different genetic models, sampling designs, null hypotheses , and missing parental information.

The purpose of this report is to compare the power of the exact FBAT with two other tests, exact conditional logistic regression (CLR) and the exact trend test for clustered data (QEM). Pedigrees of sibships were simulated based upon a variety of different parameters, …

A Comparison Of Estimation Procedures For The Beta Distribution, Huey Yan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The beta distribution may be used as a stochastic model for continuous proportions in many situations in applied statistics. This thesis was concerned with estimation of the parameters of the beta distribution in three different situations.

Three different estimation procedures-the method of moments, maximum likelihood, and a hybrid of these two methods, which we call the one-step improvement-were compared by computer simulation, for beta data and beta data contaminated by zeros and ones. We also evaluated maximum likelihood estimation in the context of censored data, and Newton's method as a numerical procedure for solving the likelihood equations …

Comparison Of Bootstrap With Other Tests For Several Distributions, Yu-Yu Wong

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This paper discusses results of a computer simulation to investigate several different tests when sampling several distributions. The hypothesis H₀: μ=0 was tested against H₀: μ≠0, using the usual t-test, trimmed t-test, the Jackkinfe, the Bootstrap and signed-rank test. The p-values and empirical power show that the Bootstrap is as good as the t-test. The Jackknife procedure is too liberal, always obtaining small p-values. The signed-rank is a fairly good test if the data follows the Cauchy Distribution.

Comparison Of Bootstrap And Jacknife Statistical Procedures, Amanuel Gobena

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This report compares the bootstrapping to jacknifing statistical procedures in terms in bias, confidence interval and estimation of median. Related literature have been reviewed. A bootstrap allows a researcher to get an approximation to the distribution of possibly complicated statistical summaries. It is based on random sampling with replacement from experimental units. Jacknife has also been in operation prior to bootstrapping statistical procedure. The jacknife divides the data into subgroups and obtains partial estimates of these subgroups by omitting one subgroup at a time. When both of these statistical resampling procedures are compared the bootstrap has less bias, more accurate …

Evaluation Of An Experiment After Analysis Of Variance, Abdullah Sulaiman Atheem

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

If experimental data are obtained according to an experimental design for which analysis of variance (AOV) is appropriate, the result of the analysis is one of the following decisions:

1. A significant difference exists among treatment effects.

2. No significant difference exists.

Interpretation in the first case has been studied very thoroughly by many statisticians resulting, for example, in the multiple comparison procedure. Too often, in the second case, the AOV analysis is thought to be completed with no further attempt to interpret a nonsignificant outcome.

Of the many possible explanations for significance in the first case, the multiple comparison …

Comparison Of Transition Matrices Between Metropolitan And Non-Metropolitan Areas In The State Of Utah Using Juvenile Court Data, Sung-Ik Song

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this paper is to use Markov Chains for the study of youths referred to the juvenile court in the metropolitan and non-metropolitan areas of the state of Utah.

Two computer programs were written for creating case histories for each person referred to the court and for testing for the significance of the difference among several transition matrices.

Another computer program, which was written by Soo Hong Uh, was used for analyzing realizations of a Markov chains up to the 4th order; a third computer program, originally written by David White, was used for interpreting Markov chains.

The …

A Monte Carlo Comparison Of Nonparametric Reliability Estimators, Jia-Jinn Yueh

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

It is very difficult to construct a reliability model for a complex system. However, the reliability model for a series configuration is relatively simple. In the simplest case in which the components are mutually independent, the system reliability can be represented as follows:

R_s(x) = ∑ⁿ_i=1R_i(x),

where R_i is the reliability for the i^th component. It is also known that for moderate levels of system reliability for large systems, the component reliability must be high.

Extreme Value Theory indicates that under very general conditions, the initial form of the distribution function …