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Full-Text Articles in Physical Sciences and Mathematics
Mechanics Of Phenotypic Aging Trajectories In C. Elegans And Humans, William Zhang
Mechanics Of Phenotypic Aging Trajectories In C. Elegans And Humans, William Zhang
Arts & Sciences Electronic Theses and Dissertations
Overall, my dissertation integrates longitudinal measurements of physiology to investigate the aging process. In the first half, I examine the surprising and largely unexplained degree of variation in lifespan within even homogeneous populations. I sought to understand how physiological aging differs between long- and short-lived individuals within a population of genetically identical C. elegans reared in a homogeneous environment. Using a novel culture apparatus, I longitudinally monitored aspects of aging physiology across a large population of isolated individuals. Aggregating several measures into an overall estimate of senescence, I find that long- and short-lived individuals start adulthood on an equal physiological …
Quantifying Human Biological Age: A Machine Learning Approach, Syed Ashiqur Rahman
Quantifying Human Biological Age: A Machine Learning Approach, Syed Ashiqur Rahman
Graduate Theses, Dissertations, and Problem Reports
Quantifying human biological age is an important and difficult challenge. Different biomarkers and numerous approaches have been studied for biological age prediction, each with its advantages and limitations. In this work, we first introduce a new anthropometric measure (called Surface-based Body Shape Index, SBSI) that accounts for both body shape and body size, and evaluate its performance as a predictor of all-cause mortality. We analyzed data from the National Health and Human Nutrition Examination Survey (NHANES). Based on the analysis, we introduce a new body shape index constructed from four important anthropometric determinants of body shape and body size: body …