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Personalized Evaluation Of Biomarker Value: A Cost-Benefit Perspective, Ying Huang, Eric Laber
Personalized Evaluation Of Biomarker Value: A Cost-Benefit Perspective, Ying Huang, Eric Laber
UW Biostatistics Working Paper Series
For a patient who is facing a treatment decision, the added value of information provided by a biomarker depends on the individual patient’s expected response to treatment with and without the biomarker, as well as his/her tolerance of disease and treatment harm. However, individualized estimators of the value of a biomarker are lacking. We propose a new graphical tool named the subject-specific expected benefit curve for quantifying the personalized value of a biomarker in aiding a treatment decision. We develop semiparametric estimators for two general settings: i) when biomarker data are available from a randomized trial; and ii) when biomarker …