Physical Sciences and Mathematics Commons^™

Characterizing Expected Benefits Of Biomarkers In Treatment Selection, Ying Huang, Eric Laber, Holly Janes

UW Biostatistics Working Paper Series

Biomarkers associated with the treatment response heterogeneity hold potential for treatment selection. In practice, the decision regarding whether to adopt a treatment selection marker depends on the effect of treatment selection on the rate of targeted disease as well as additional cost associated with the treatment. We propose an expected benefit measure that incorporates both aspects to quantify a biomarker's treatment selection capacity. This measure extends an existing decision-theoretic framework, to account for the fact that optimal treatment absent marker information varies with the cost of treatment. In addition, we establish upper and lower bounds for the performance of a …