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Full-Text Articles in Physical Sciences and Mathematics
Choosing The Cut Point For A Restricted Mean In Survival Analysis, A Data Driven Method, Emily H. Sheldon
Choosing The Cut Point For A Restricted Mean In Survival Analysis, A Data Driven Method, Emily H. Sheldon
Theses and Dissertations
Survival Analysis generally uses the median survival time as a common summary statistic. While the median possesses the desirable characteristic of being unbiased, there are times when it is not the best statistic to describe the data at hand. Royston and Parmar (2011) provide an argument that the restricted mean survival time should be the summary statistic used when the proportional hazards assumption is in doubt. Work in Restricted Means dates back to 1949 when J.O. Irwin developed a calculation for the standard error of the restricted mean using Greenwood’s formula. Since then the development of the restricted mean has …
A New Method For The Comparison Of Survival Distributions, Jaymie Shanahan
A New Method For The Comparison Of Survival Distributions, Jaymie Shanahan
Theses and Dissertations
The assessment of overall homogeneity of time-to-event curves is a key element in survival analysis in biomedical research. The currently commonly used testing methods, e.g. log-rank test, Wilcoxon test, and Kolmogorov-Smirnov test, may have a significant loss of statistical testing power under certain circumstances. In this thesis we replicate a testing method (Lin & Xu, 2009) that is robust for the comparison of the overall homogeneity of survival curves based on the absolute difference of the area under the survival curves using normal approximation by Greenwood's formula, and propose a new weight component to their test statistic. The weight component …