Physical Sciences and Mathematics Commons^™

Sample Size Estimation For Linear Mixed Models With Dependent End Points, Michael Nsiah-Nimo

Open Access Theses & Dissertations

The primary objective is sample size estimation in linear mixed model settings. Sample size estimation is an important component of planning a well thought out scientific experiment. Whenever sample size estimation is performed, taking into account a priori model based inferences will provide a sample size estimate that will achieve the desired power without inflating the type I error rate of the study.

One common practice is a traditional approach cited in the literature that uses the largest sample size after you Bonferroni the type I error rate to estimate sample sizes as such. We are going to take into …