Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Notes On Hypothesis Testing Under A Single-Stage Design In Phase Ii Trial, Kung-Jong Lui
Notes On Hypothesis Testing Under A Single-Stage Design In Phase Ii Trial, Kung-Jong Lui
Journal of Modern Applied Statistical Methods
A primary objective of a phase II trial is to determine future development is warranted for a new treatment based on whether it has sufficient activity against a specified type of tumor. Limitations exist in the commonly-used hypothesis setting and the standard test procedure for a phase II trial. This study reformats the hypothesis setting to mirror the clinical decision process in practice. Under the proposed hypothesis setting, the critical points and the minimum required sample size for a desired power of finding a superior treatment at a given α -level are presented. An example is provided to illustrate how …
An Equivalence Test Based On N And P, Markus Neuhäeuser
An Equivalence Test Based On N And P, Markus Neuhäeuser
Journal of Modern Applied Statistical Methods
An equivalence test is proposed which is based on the P-value of a test for a difference and the sample size. This test may be especially appropriate for an exploratory re-analysis if only a non-significant test for a difference was reported. Thus, neither a confidence interval is available, nor is there access to the raw data. The test is illustrated using two examples; for both applications the smallest equivalence range for which equivalence could be demonstrated is calculated.