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Full-Text Articles in Physical Sciences and Mathematics
Genetics Analysis Workshop 20: Methods And Strategies For The New Frontiers Of Epigenetics And Pharmacogenomics, Nathan L. Tintle, David W. Fardo, Mariza De Andrade, Stella Aslibekyan, Julia N. Bailey, Justo Lorenzo Bermejo, Rita M. Cantor, Saurabh Ghosh, Philip Melton, Xuexia Wang, Jean W. Maccluer, Laura Almasy
Genetics Analysis Workshop 20: Methods And Strategies For The New Frontiers Of Epigenetics And Pharmacogenomics, Nathan L. Tintle, David W. Fardo, Mariza De Andrade, Stella Aslibekyan, Julia N. Bailey, Justo Lorenzo Bermejo, Rita M. Cantor, Saurabh Ghosh, Philip Melton, Xuexia Wang, Jean W. Maccluer, Laura Almasy
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GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual …
Student Gains In Conceptual Understanding In Introductory Statistics With And Without A Curriculum Focused On Simulation-Based Inference, Beth Chance, Stephanie Mendoza, Nathan L. Tintle
Student Gains In Conceptual Understanding In Introductory Statistics With And Without A Curriculum Focused On Simulation-Based Inference, Beth Chance, Stephanie Mendoza, Nathan L. Tintle
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Using “simulation-based inference” (SBI) such as randomization tests as the primary vehicle for introducing students to the logic and scope of statistical inference has been advocated with the potential of improving student understanding of statistical inference, as well as the statistical investigative process as a whole. Moving beyond the individual class activity, entirely revised introductory statistics curricula centering on these ideas have been developed and tested. In this presentation we will discuss three years of cross-institutional tertiary-level data in the United States comparing SBI-focused curricula and non-SBI curricula (roughly 15,000 students). We examine several pre/post measures of conceptual understanding in …
Development Of A Tool To Assess Students’ Conceptual Understanding In Introductory Statistics, Nathan L. Tintle, Jill Vander Stoep
Development Of A Tool To Assess Students’ Conceptual Understanding In Introductory Statistics, Nathan L. Tintle, Jill Vander Stoep
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Few tools exist to assess students’ conceptual understanding in post-secondary, introductory statistics courses. The CAOS test is widely considered to be the gold standard, but was first published in 2007 and does not necessarily reflect some of the changes in student learning at the secondary level. Furthermore, it may not be sensitive enough to measure student conceptual understanding in modern post-secondary statistics courses (e.g., simulation-based inference). In this paper we will describe the process of developing a new instrument which uses some CAOS items, as well as additional new items to improve validity and reliability. We will share the validity …