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Full-Text Articles in Physical Sciences and Mathematics
Bayesian Analysis For The Intraclass Model And For The Quantile Semiparametric Mixed-Effects Double Regression Models, Duo Zhang
Dissertations, Master's Theses and Master's Reports
This dissertation consists of three distinct but related research projects. The first two projects focus on objective Bayesian hypothesis testing and estimation for the intraclass correlation coefficient in linear models. The third project deals with Bayesian quantile inference for the semiparametric mixed-effects double regression models. In the first project, we derive the Bayes factors based on the divergence-based priors for testing the intraclass correlation coefficient (ICC). The hypothesis testing of the ICC is used to test the uncorrelatedness in multilevel modeling, and it has not well been studied from an objective Bayesian perspective. Simulation results show that the two sorts …
Statistical Methods For Joint Analysis Of Multiple Phenotypes And Their Applications For Phewas, Xueling Li
Statistical Methods For Joint Analysis Of Multiple Phenotypes And Their Applications For Phewas, Xueling Li
Dissertations, Master's Theses and Master's Reports
Genome-wide association studies (GWAS) have successfully detected tens of thousands of robust SNP-trait associations. Earlier researches have primarily focused on association studies of genetic variants and some well-defined functions or phenotypic traits. Emerging evidence suggests that pleiotropy, the phenomenon of one genetic variant affects multiple phenotypes, is widespread, especially in complex human diseases. Therefore, individual phenotype analyses may lose statistical power to identify the underlying genetic mechanism. Contrasting with single phenotype analyses, joint analysis of multiple phenotypes exploits the correlations between phenotypes and aggregates multiple weak marginal effects and is therefore likely to provide new insights into the functional consequences …
Statistical Methods For Mixed Frequency Data Sampling Models, Yun Liu
Statistical Methods For Mixed Frequency Data Sampling Models, Yun Liu
Dissertations, Master's Theses and Master's Reports
The MIDAS models are developed to handle different sampling frequencies in one regression model, preserving information in the higher sampling frequency. Time averaging has been the traditional parametric approach to handle mixed sampling frequencies. However, it ignores information potentially embedded in high frequency. MIDAS regression models provide a concise way to utilize additional information in HF variables. While a parametric MIDAS model provides a parsimonious way to summarize information in HF data, nonparametric models would maintain more flexibility at the expense of the computational complexity. Moreover, one parametric form may not necessarily be appropriate for all cross-sectional subjects. This thesis …