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The Effect Of Baseline Cluster Stratification On The Power Of Pre-Post Analysis, Fengjiao Hu
The Effect Of Baseline Cluster Stratification On The Power Of Pre-Post Analysis, Fengjiao Hu
Theses and Dissertations
The purpose of study is to check whether the power of detecting the effect of intervention versus control in a pre- and post-study can be increased by using a stratified randomized controlled design. A stratified randomized controlled design with two study arms and two time points, where strata are determined by clustering on baseline outcomes of the primary measure, is considered. A modified hierarchical clustering algorithm is developed which guarantees optimality as well as requiring each cluster to have at least one subject per study arm. The power is calculated based on simulated bivariate normal distributed primary measures with mixture …