Physical Sciences and Mathematics Commons^™

A Method For Finding Standard Error Estimates For Rma Expression Levels Using Bootstrap, Gabriel Nicholas

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Oligonucleotide arrays are used in many applications. Affymetrix GeneChip arrays are widely used. Before researchers can use the information from these arrays, the raw data must be transformed and summarized into a more meaningful and usable form. One of the more popular methods for doing so is RMA (Robust Multi-array Analysis).

A problem with RMA is that the end result (estimated gene expression levels) is based on a fairly complicated process that is unusual. Specifically, there is no closed-form estimate of standard errors for the estimated gene expression levels. The current recommendation is to use a naive estimate for the …

Optimal Path Planning And The Fast Marching Method, J. J. Clark

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The problem of determining an optimal path for an object moving through some obstacle space presents several nontrivial subproblems. The foremost being the computational complexity that is involved and how to best deal with the associated large data volume. For example, a non-symmetric object moving in three dimensions possesses six degrees of freedom. This can lead to a computational grid that may easily be on the order of 10¹². Furthermore, for every point in the computational domain, several complex calculations must be performed. These include performing tests to determine if the object and obstacles intersect, and numerically solving …