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Comparison Of Exact Methods For Analyzing Family-Based Samples, Abbie Lundgreen
Comparison Of Exact Methods For Analyzing Family-Based Samples, Abbie Lundgreen
All Graduate Plan B and other Reports, Spring 1920 to Spring 2023
Family-based association tests are used to identify genes that increase the risk of developing a disease, while controlling for spurious associations caused by population structure. The exact family-based association test, exact FBAT, is a unified approach which can be app lied to tests of different genetic models, sampling designs, null hypotheses , and missing parental information.
The purpose of this report is to compare the power of the exact FBAT with two other tests, exact conditional logistic regression (CLR) and the exact trend test for clustered data (QEM). Pedigrees of sibships were simulated based upon a variety of different parameters, …