Physical Sciences and Mathematics Commons^™

Bayesian Inference On Mixed-Effects Models With Skewed Distributions For Hiv Longitudinal Data, Ren Chen

USF Tampa Graduate Theses and Dissertations

Statistical models have greatly improved our understanding of the pathogenesis of HIV-1 infection

and guided for the treatment of AIDS patients and evaluation of antiretroviral (ARV) therapies.

Although various statistical modeling and analysis methods have been applied for estimating the

parameters of HIV dynamics via mixed-effects models, a common assumption of distribution is

normal for random errors and random-effects. This assumption may lack the robustness against

departures from normality so may lead misleading or biased inference. Moreover, some covariates

such as CD4 cell count may be often measured with substantial errors. Bivariate clustered

(correlated) data are also commonly encountered in …