Physical Sciences and Mathematics Commons^™

A New Method For The Comparison Of Survival Distributions, Jaymie Shanahan

Theses and Dissertations

The assessment of overall homogeneity of time-to-event curves is a key element in survival analysis in biomedical research. The currently commonly used testing methods, e.g. log-rank test, Wilcoxon test, and Kolmogorov-Smirnov test, may have a significant loss of statistical testing power under certain circumstances. In this thesis we replicate a testing method (Lin & Xu, 2009) that is robust for the comparison of the overall homogeneity of survival curves based on the absolute difference of the area under the survival curves using normal approximation by Greenwood's formula, and propose a new weight component to their test statistic. The weight component …