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Cramer Type Moderate Deviations For Random Fields And Mutual Information Estimation For Mixed-Pair Random Variables, Aleksandr Beknazaryan
Cramer Type Moderate Deviations For Random Fields And Mutual Information Estimation For Mixed-Pair Random Variables, Aleksandr Beknazaryan
Electronic Theses and Dissertations
In this dissertation we first study Cramer type moderate deviation for partial sums of random fields by applying the conjugate method. In 1938 Cramer published his results on large deviations of sums of i.i.d. random variables after which a lot of research has been done on establishing Cramer type moderate and large deviation theorems for different types of random variables and for various statistics. In particular results have been obtained for independent non-identically distributed random variables for the sum of independent random to estimate the mutual information between two random variables. The estimates enjoy a central limit theorem under some …
Mefenamic Acid – Hpmc As Hg Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt Extrusion Technology, Ashay Shukla
Mefenamic Acid – Hpmc As Hg Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt Extrusion Technology, Ashay Shukla
Electronic Theses and Dissertations
Mefenamic acid, a BCS class II drug, displays high permeability and low solubility, thereby exhibiting a poor dissolution profile. Hence to improve the solubility and dissolution rate of Mefenamic acid, Hot Melt Extrusion (HME) technique was employed. The amorphous solid dispersion matrix exhibited enhanced dissolution with desired release characteristics. Hydroxypropylmethylcellulose acetate succinate (AquaSolve™ HPMC-AS HG) was used as a carrier with the poloxamer (Kolliphor P407). The drug load was varied from 20% to 40% within the blend. Drug and polymers were blended using a twin shell V-blender for 10 minutes and extruded using an 11mm twin-screw co-rotating extruder (ThermoFisher Scientific, …