Physical Sciences and Mathematics Commons^™

Acute Systemic Inflammatory Response To Lipopolysaccharide Stimulation In Pigs Divergently Selected For Residual Feed Intake, Haibo Liu, Kristina M. Feye, Yet T. Nguyen, Anoosh Rakhshandeh, Crystal L. Loving, Jack C. M. Sekkers, Nicholas K. Gabler, Christopher K. Tuggle

Mathematics & Statistics Faculty Publications

Background: It is unclear whether improving feed efficiency by selection for low residual feed intake (RFI) compromises pigs’ immunocompetence. Here, we aimed at investigating whether pig lines divergently selected for RFI had different inflammatory responses to lipopolysaccharide (LPS) exposure, regarding to clinical presentations and transcriptomic changes in peripheral blood cells.

Results: LPS injection induced acute systemic inflammation in both the low-RFI and high-RFI line (n = 8 per line). At 4 h post injection (hpi), the low-RFI line had a significantly lower (p= 0.0075) mean rectal temperature compared to the high-RFI line. However, no significant differences in complete blood count …

Copula-Based Zero-Inflated Count Time Series Models, Mohammed Sulaiman Alqawba

Mathematics & Statistics Theses & Dissertations

Count time series data are observed in several applied disciplines such as in environmental science, biostatistics, economics, public health, and finance. In some cases, a specific count, say zero, may occur more often than usual. Additionally, serial dependence might be found among these counts if they are recorded over time. Overlooking the frequent occurrence of zeros and the serial dependence could lead to false inference. In this dissertation, we propose two classes of copula-based time series models for zero-inflated counts with the presence of covariates. Zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB), and zero-inflated Conway-Maxwell-Poisson (ZICMP) distributed marginals of the …

Responding To Some Challenges Posed By The Re-Identification Of Anonymized Personal Data, Herman T. Tavani, Frances S. Grodzinsky

Computer Ethics - Philosophical Enquiry (CEPE) Proceedings

In this paper, we examine a cluster of ethical controversies generated by the re-identification of anonymized personal data in the context of big data analytics, with particular attention to the implications for personal privacy. Our paper is organized into two main parts. Part One examines some ethical problems involving re-identification of personally identifiable information (PII) in large data sets. Part Two begins with a brief description of Moor and Weckert’s Dynamic Ethics (DE) and Nissenbaum’s Contextual Integrity (CI) Frameworks. We then investigate whether these frameworks, used together, can provide us with a more robust scheme for analyzing privacy concerns that …

Dynamic Attribute-Level Best Worst Discrete Choice Experiments, Amanda Working, Mohammed Alqawba, Norou Diawara

Mathematics & Statistics Faculty Publications

Dynamic modelling of decision maker choice behavior of best and worst in discrete choice experiments (DCEs) has numerous applications. Such models are proposed under utility function of decision maker and are used in many areas including social sciences, health economics, transportation research, and health systems research. After reviewing references on the study of such experiments, we present example in DCE with emphasis on time dependent best-worst choice and discrimination between choice attributes. Numerical examples of the dynamic DCEs are simulated, and the associated expected utilities over time of the choice models are derived using Markov decision processes. The estimates are …

Rates Of Relative Sea Level Rise Along The United States East Coast, Jesse N. Beckman, Joseph E. Garcia

Virginia Journal of Science

Recent studies have indicated that some coastal areas, including the East Coast of the United States, are experiencing higher rates of sea level rise than the global average. Rates of relative sea level rise are affected by changes in ocean dynamics, as well as by surface elevation fluctuations due to local land subsidence or uplift. In this study, we derived long-term trends in annual mean relative sea level using tide gauge data obtained from the Permanent Service for Mean Sea Level for stations along the United States East Coast. Stations were grouped by location into the Northeast, Mid-Atlantic, and Southeast …

Spatio-Temporal Cluster Detection And Local Moran Statistics Of Point Processes, Jennifer L. Matthews

Mathematics & Statistics Theses & Dissertations

Moran's index is a statistic that measures spatial dependence, quantifying the degree of dispersion or clustering of point processes and events in some location/area. Recognizing that a single Moran's index may not give a sufficient summary of the spatial autocorrelation measure, a local indicator of spatial association (LISA) has gained popularity. Accordingly, we propose extending LISAs to time after partitioning the area and computing a Moran-type statistic for each subarea. Patterns between the local neighbors are unveiled that would not otherwise be apparent. We consider the measures of Moran statistics while incorporating a time factor under simulated multilevel Palm distribution, …

A Data-Driven Approach For Modeling Agents, Hamdi Kavak

Computational Modeling & Simulation Engineering Theses & Dissertations

Agents are commonly created on a set of simple rules driven by theories, hypotheses, and assumptions. Such modeling premise has limited use of real-world data and is challenged when modeling real-world systems due to the lack of empirical grounding. Simultaneously, the last decade has witnessed the production and availability of large-scale data from various sensors that carry behavioral signals. These data sources have the potential to change the way we create agent-based models; from simple rules to driven by data. Despite this opportunity, the literature has neglected to offer a modeling approach to generate granular agent behaviors from data, creating …

Latent Choice Models To Account For Misclassification Errors In Discrete Transportation Data, Lacramioara Elena Balan

Civil & Environmental Engineering Theses & Dissertations

One of the most fundamental tasks when it comes to analyzing data using statistical methods is to understand the relationship between the explanatory variables and the outcome. Misclassification of explanatory variables is a common risk when using statistical modeling techniques. In this dissertation, we define ‘misclassification,’ as a response that is reported or recorded in the wrong category; for example, a variable is registered as a one when it should have the value zero. Misclassification can easily happen in any data; for example, in an interview setting where the respondent misunderstands the question or the interviewer checks the wrong box. …

Disparities In Sentencing: The Impact Of Race, Gender And Mental Health, Briana Paige

Sociology & Criminal Justice Theses & Dissertations

The purpose of this study is to examine the effect that race and mental health play on sentence length in the United States. Mentally ill people are gradually being confined in prisons across the United States and there is an absence of literature that looks at the interaction of race and mental health in regards to sentencing. The focal concerns perspective provides the theoretical framework that guides this study. Multiple linear regressions were used to examine both state and federal prison inmates to examine the effect race, mental health and other extra-legal factors play on sentence length. Results show that …

How Ceo Wealth Affects The Riskiness Of A Firm, Sonik Mandal, Charlie Swartz, Sanjib Guha, Carl B. Mcgowan Jr.

Finance Faculty Publications

The objective of this paper is to analyze the relationship between the ownership level of managers and the risk averse behavior of the firm. We measure the ownership level of the managers by the ratio of their ownership of the company relative to their total wealth for a sample of 69 individuals from the Forbes 400 list of the wealthiest individuals in the world for the period from 2001-11 using an unbalanced panel data analysis. The dependent variable is the Altman Z-score of each firm and we further test these relationships using financial leverage. The independent variables are delta and …

Dimensionality And Factorial Invariance Of Religiosity Among Christians And The Religiously Unaffiliated: A Cross-Cultural Analysis Based On The International Social Survey Programme, Carlos Miguel Lemos, Ross Joseph Gore, Ivan Puga-Gonzalez, F. Leron Shults

VMASC Publications

We present a study of the dimensionality and factorial invariance of religiosity for 26 countries with a Christian heritage, based on the 1998 and 2008 rounds of the International Social Survey Programme (ISSP) Religion survey, using both exploratory and multi-group confirmatory factor analyses. The results of the exploratory factor analysis showed that three factors, common to Christian and religiously unaffiliated respondents, could be extracted from our initially selected items and suggested the testing of four different three-factor models using multi-group confirmatory factor analysis. For the model with the best fit and measurement invariance properties, we labeled the three resulting factors …

Controlling For Confounding Via Propensity Score Methods Can Result In Biased Estimation Of The Conditional Auc: A Simulation Study, Hadiza I. Galadima, Donna K. Mcclish

Community & Environmental Health Faculty Publications

In the medical literature, there has been an increased interest in evaluating association between exposure and outcomes using nonrandomized observational studies. However, because assignments to exposure are not random in observational studies, comparisons of outcomes between exposed and nonexposed subjects must account for the effect of confounders. Propensity score methods have been widely used to control for confounding, when estimating exposure effect. Previous studies have shown that conditioning on the propensity score results in biased estimation of conditional odds ratio and hazard ratio. However, research is lacking on the performance of propensity score methods for covariate adjustment when estimating the …