Open Access. Powered by Scholars. Published by Universities.®
![Digital Commons Network](http://assets.bepress.com/20200205/img/dcn/DCsunburst.png)
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
Comparing Region Level Testing Methods For Differential Dna Methylation Analysis, Arnold Albert Harder
Comparing Region Level Testing Methods For Differential Dna Methylation Analysis, Arnold Albert Harder
Masters Theses
”Finding possible connections and solutions to help fight progression of diseases is a major area of research. Genomics is a primary path of research in disease research. Through the DNA sequence, possible connections to diseases have been found. However, most methods for fixing issues within a DNA sequence are still out of reach. One potential path is to investigate epigenetic modifications, such as DNA methylation. DNA methylation occurs when a methyl group attached to cytosines on the DNA sequence. Statistical methods can be used to identify sites or regions of significant differences in methylation levels between groups ( e. g. …
Family-Based Association Studies Of Autism In Boys Via Facial-Feature Clusters, Luke Andrew Settles
Family-Based Association Studies Of Autism In Boys Via Facial-Feature Clusters, Luke Andrew Settles
Masters Theses
"Autism spectrum disorder (ASD) refers to a set of developmental disorders with varied attributes. Due to its substantial heterogeneity in terms of behavioral and clinical phenotypes, it is challenging to discern the genetic biomarkers behind ASD, even though the disease is known to be genetic in nature. This serves as a motivation to detect relationships between single nucleotide polymorphisms (SNPs) and a causal autism disease susceptibility locus (DSL) within more homogeneous subgroups. Recently, clinically meaningful subclassifications of ASD have been discovered utilizing facial features of prepubescent boys. Therefore, through the employment of data from 44 prepubertal Caucasian boys with ASD …
Development Of A Variogram Approach To Spatial Outlier Detection Using A Supplemental Digital Elevation Model Dataset, Zane Daniel Helwig
Development Of A Variogram Approach To Spatial Outlier Detection Using A Supplemental Digital Elevation Model Dataset, Zane Daniel Helwig
Masters Theses
"When developing a ground water model, the quality of the dataset should first be evaluated. Spatial outliers can lead to predictions which are not representative of actual conditions. In order to isolate misrepresentative points, a method is presented which examines the experimental variogram of a ground water elevation dataset. To define a threshold variance between pairs of ground water elevation measures, ground elevation values from a digital elevation model (DEM) are used to determine a maximum reasonable variance expected to occur on the experimental variogram. To determine appropriate DEM parameters, a separate study was also done which observed characteristic behavior …